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Biomedical subjects

O Keller

Publications and source records attributed to O Keller.

At least 55 records · Page 3Linked to original sources
PubMed1974

Antileishmanial effect of allopurinol.

Allopurinol (4-hydroxypyrazolo[3,4-d]pyrimidine) has been shown to inhibit the growth of Leishmania braziliensis in vitro at concentrations which are attainable in human tissues and body fluids. This compound is believed to act by interdicting the de novo synthesis of pyrimidines, probably through the formation of allopurinol ribotide. Its lack of toxicity makes it a potential candidate for animal experimentation and it may serve as a prototype for other agents with similar mechanisms of action.

Allopurinol↗
PubMed1973

Central projection of tooth pulp primary afferents in the cat.

Stimulation of the tooth pulp nerve, consisting of A-delta fibers, produces field potentials in the rostal subdivision of the nucles, tractus spinalis n. trigmini. Antidromic action potentials from the A-delta fibers of the tooth pulp nerve, and increased excitability of their central terminals after a preceding volley in other trigeminal branches, can be recorded only when the stimulating microelectrode is inserted into this region. Stimulation of tooth pulp afferents produces a jaw opening reflex, but no response in the facial musculature. This is in contrast to the action evoked from the A-alpha fibers in other trigeminal branches which elicit reflexes only in the facial musculature. Cortical responses, evoked by a volley in the tooth pulp nerve, can be recorded from the lateral part of the coronal gyrus. By systematic tracking with microelectrodes, three sources of negative field potentials with superimposed unit activity were found. The first is localized in the cortex of the coronal gyrus; the second and the third in the anterior ectosylvian and orbital gyri, the cortex of which infolds into the diagonal sulcus,

Action Potentials↗