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Biomedical subjects

O Karlog

Publications and source records attributed to O Karlog.

4 recordsLinked to original sources
PubMed1978

Toxicokinetics.

The absorption, distribution and elimination of toxic compounds can be described by means of kinetic parameters such as used in pharmacology. Administration of toxic doses may lead to changes in some of the parameters. The toxic effect may further influence the known parameters of some test substances. Toxicokinetic parameters will be described using examples from two groups of compounds 1) naturally occurring toxic compounds and 2) synthetic compounds. Changes in elimination parameters caused by toxic substances will be demonstrated a.o. the effect of long term intake of ochratoxin A and methoxyethyl mercury on the kidney function in swine. In both examples are demonstrated a pronounced reduction in the clearances of inulin and para-amino-hippuric acid. Furthermore, an elucidation of concentration dependent change in enzyme activity and changes in metabolism of pesticides will be given. As examples alkylphosphates and dinitrophenols in domestic animals will be used.

Animals↗
PubMedDate not supplied

[Parathion poisoning in cattle (author's transl)].

In a herd of dairy cattle half of the cows showed symptoms of acute poisoning. Blood- and hair samples were taken from seven of the cows, of which two did not show any clinical symptoms. The cholinesterase activities were in all the blood samples decreased to about 10 per cent of normal and parathion was found in all hair samples. The cholinesterase activities rose gradually during a 31/2 month period to the lower part of the normal range. Parathion was found in samples from the inner walls of the cowstable, and it was concluded that the poisoning was probably due to parathion spraying in the stable, while a suspicion of winddrift as a source of poisoning was rejected as less probable.

Aerosols↗
PubMedDate not supplied

Thallium loading in owls and other birds of prey in Denmark.

Due to previous findings of increased concentrations of the rodenticid, thallium, in free-living Danish carnivores, thallium analysis has been carried out on material from 77 owls and birds of prey. Thallium was found in 2/3 of the birds and in 10% the concentration was so high that the load of thallium may have caused the death of the birds. The load of thallium in birds of prey was lower than concentrations found in carnivores, probably because poisoning caused by direct intake of thallium baits placed for rodent control does not seem to occur among birds of prey. From the investigation of this limited number of birds, it is not possible to tell if thallium did have any influence on the maintenance of a healthy population of birds of prey, but the large number of thallium loaded birds also justify the restrictions in the sue of thallium which were given from the 1st of July, 1975.

Animals↗