Search PubMed⌕ Search

Biomedical subjects

O K Shaposhnikov

Publications and source records attributed to O K Shaposhnikov.

At least 19 recordsLinked to original sources
PubMed1990

[The principles of the combined conservative treatment of trophic ulcers of the lower extremities].

Conservative treatment of trophic ulcers of the lower limbs should be combined, prolonged and continuous, universal and individualized with due consideration for the condition of the ulcer and the underlying process. Continuity of therapeutic measures carried out on an inpatient and outpatient basis is of great importance. Conservative treatment includes resting with the limb elevated, compensation of trophic ulcer activity symptoms, excess body mass control, prolonged intake of present-day angiotrophic drugs, courses of drug therapy to improve reparative processes, external therapy to improve trophic ulcer tissue condition.

Combined Modality Therapy↗
PubMed1990

[The pathogenesis of trophic ulcers of the lower extremities].

The notion of a trophic ulcer is nosologically indefinite at present. Basing on current understanding of the pathogenesis of the processes that underlie the development of trophic ulcers on the lower limbs, the authors present a classification of such ulcers. They suggest a working scheme of trophic ulcers pathogenesis; according to this scheme, impaired blood microcirculation [correction of microhemocirculation] in the skin underlies the development of trophic ulcers on the lower limbs. These disorders involve hemocoagulation, angiopathic, and chronic inflammatory processes in the derma, that lead to necrosis and sclerosis of dermal connective tissue. Contribution of the body reactivity characteristics to the formation of trophic ulcers is discussed, as are the role of skin morphofunctional features and of exogenous factors. The authors believe that closely related pathogenetic mechanisms of trophic ulcer development imply treatment with the same complex of therapeutic modalities.

Connective Tissue↗
PubMed1989

[Transitory (presystemic) forms of lupus erythematosus and characteristics of their immunotherapy].

The authors' findings confirm the possibility of such forms. In 16.5% of cases lupus erythematosus transforms from the discoid form and in 6.9% of cases from the disseminated form, immunologically presenting as T- or B-dependent lupus erythematosus. The authors describe immunocorrecting therapy for various forms of the disease, including immunosuppression of T- and B-lymphocytes by the quinoline series drugs or by their combinations with corticosteroids, as well as immunostimulation of T-lymphocytes by the imidazole series drugs or by thymus hormones.

Adolescent↗
PubMed1985

[Immunological aspects of Kaposi's disease].

A dynamic complex evaluation of immunologic vigor was carried out in 17 cases of Kaposi's sarcoma. Immunologic disorders were found to be in a correlation with clinical course. Three groups were identified: (1) patients with favourable prognosis (OKT4+/OKT8+ ratio--1.46 +/- 0.09), (12) slowly advancing disease (OKT4+/OKT8+ ratio--0.87 +/- 0.13) and (3) unfavorable clinical course (OKT4+/OKT8+ ratio--0.47 +/- 0.04). The said variations are comparable to those of cyclic nucleotide level in blood lymphocytes.

B-Lymphocytes↗