[Causes of eczema demonstrated by patch tests in a specialized dermatological practice].
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Biomedical subjects
Publications and source records attributed to O Justesen.
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Five to 22 years after warts on hands and feet were treated by X ray, 1122 patients with a total of 3675 warts were re-examined. X-Ray therapy had been given as one dose of 3000 r using 29 kV with a 0.3-mm Al filter; 19% of the warts had been given two treatments. Sequelae were seen in 4.8% of the sites where warts had been given one X-ray treatment and in 12.2% of the sites after two treatments. These side effects include hyperkeratosis in the pressure areas of palms and soles and atrophy primarily in areas with a thin cutis. There was no evidence of malignant transformation in any treatment site, and there were no deep-seated side effects such as ostitis or tendinitis.
168 children, 14 years of age or younger, were patch tested with the Standard Series of the International Contact Dermatitis Research Group (ICDRG) over a 5-year period. 77 of the children had 1 or more positive reactions; relevant test results were found in 80% of them. 8 boys and 24 girls were allergic to nickel, which proved to be the most common allergen; 5 boys and 6 girls reacted to chromate, and 5 boys and 4 girls reacted to one or more of the rubber chemicals.
145 of 1116 patients patch tested with the standard series of the International Contact Dermatitis Research Group, including the recently introduced perfume mixture, had positive patch test reactions to at least one of the traditional screening agents for fragrance allergy or to the perfume mixture. In 96 of 145 patients the positive patch tests could be explained as being related to fragrance allergy. The perfume mixture was considered a useful screening agent for fragrance allergy. However, the results indicate that it is still necessary to employ several screening agents to detect this type of hypersensitivity.
Nine farmers suspected of having occupational contact dermatitis had positive patch tests to spiramycin and/or tylosin. After diagnosis the dermatitis cleared or improved markedly in seven patients; five of these stopped using the antibiotics in question, and two began to wear gloves while handling the drugs. The two patients who continued use of the drugs and took no precautionary measures had little change in the activity of the dermatitis.
In a double-blind randomized comparative multicenter trial, consisting of 29 patients with acne vulgaris who were unable to tolerate daily applications of retinoic acid, the retinoic acid derivative Ro 11--1430 (0.1% vanishing cream) was compared in a 6--8 weeks topical treatment with vanishing cream alone (placebo). Regarding efficacy, for most criteria measured the response was always better with Ro 11--1430 than with placebo, although the differences were not always statistically significant for several reasons, one probably being the small number of patients in the trial. Regarding tolerance, both treatments were satisfactory. Ro 11---1430 and placebo did not differ significantly regarding frequency and severity of erythema, desquamation and burning. These results suggest that treatment with Ro 11--1430 should be considered in acne patients who are unable to use retinoic acid due to severe local reactions.
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