An antigen-antibody reaction occurring in the perfused sensitized guinea pig lung, has been demonstrated to release kallikrein, a proteolytic enzyme related to the formation of kinins. This lung kallikrein is similar to plasma kallikrein in all properties studied, including susceptibility to the same inhibitors, electrophoretic mobility, and heterogeneity in molecular size. The release of kallikrein during anaphylaxis in the guinea pig lung occurs in the presence of ethylenediaminetetraacetate. Perfusion of ellagic acid into nonsensitized lungs will also release kallikrein, presumably through activation of Hageman factor. On the basis of these findings the hypothesis is suggested that the kallikrein in perfused lung activated by the antigen-antibody reaction is, in fact, plasma kallikrein. It is further suggested that activation of such kallikrein by the antigen-antibody reaction proceeds through Hageman factor.

Anaphylaxis↗

PubMed1966

Intraluminal leiomyosarcoma of the inferior vena cava. Report of a case.

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Adult↗

PubMed1966

Preparation of antiserum specifically directed against human complement.

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Animals↗

PubMedDate not supplied

Tuberculosis of the liver in end stage renal disease under treatment with hemodialysis.

We present a patient with end stage renal disease treated with hemodialysis, who developed prolonged fever and hepatomegaly. A laparotomy and culture of liver microabscesses led to the diagnosis of tuberculosis of the liver. A complete clinical response was achieved with a course of isoniazid and rifampin.

Adolescent↗

PubMedDate not supplied

Total parathyroidectomy and autotransplantation in secondary hyperparathyroidism.

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Humans↗