Biomedical subjects

O J Sizemore

Publications and source records attributed to O J Sizemore.

4 recordsLinked to original sources

PubMed1997

Human neurobehavioral research methods: impact of subject variables.

Behavioral tests are used in work site and community research to detect and characterize the effects of neurotoxic chemical exposures in human populations, but the influence of subject variables on test performance has not been well studied in normal adult populations. This research sought to evaluate the impact of two variables, education and cultural group, on 18 widely used tests of neurotoxic insult. Behavioral tests from the two consensus neurotoxicity test batteries (established by the World Health Organization and the U.S. Agency for Toxic Substances and Disease Registry) were administered to 715 people aged 26-45 with 0-18 years of education, drawn from European descent United States majority, American Indian, African American, and Latin American populations. Education, cultural group, age, and gender affected the outcome of behavioral tests as revealed by ANOVA, MANOVA, and multiple regression techniques. Education, followed by cultural group, accounted for the most variance in the tests studied. More importantly, years of education and cultural group had 13-25% shared variance on the cognitive tests and highly significant interactions derived from ANOVA tests. This suggests that these factors should be controlled in the design of a study rather than in the statistical analysis. Because these factors can mimic a neurotoxic insult, failure to adequately control and analyze them could lead to inaccurate conclusions about the association between poor performance and neurotoxic insult.

Adult↗

PubMed1996

Characteristics of ATSDR's adult and pediatric environmental neurobehavioral test batteries.

In 1991 the Agency for Toxic Substances and Disease Registry selected a group of neurobehavioral tests to be used in the screening of individuals living near hazardous waste sites. Data from a review of 185 work site studies show that the Adult Neurobehavioral Environmental Test Battery (AENTB) is comprised of tests that have been used to study a wide range of toxic chemicals and that have proved to be capable of detecting impaired populations. Efforts to evaluate potentially impaired populations will be aided by an extensive planning and test administration manual. Progress toward the development of a pediatric counterpart (Pediatric Neurobehavioral Environmental Test Battery [PENTB]) is also reviewed.

Adult↗

PubMedDate not supplied

Human behavioral assessment in neurotoxicology: producing appropriate test performance with written and shaping instructions.

Neurotoxic effects are of such breadth and complexity that functional biomarkers (behavioral tests) that integrate many areas of the nervous system predominate in human neurotoxicology research. The increasing distribution of chemical and other manufacturing throughout the world, particularly in developing nations, suggests the acute need to develop biomarkers for chemical exposures and effects that can be employed internationally. A language-free method for training performance on behavioral tests is described, which holds promise for international research that circumvents the vagaries of translation. Four behavioral tests were administered to 74-114 adult US subjects. Procedures, collectively termed shaping, produced effective performance on three tests [Symbol Digit, Vigilant Attention Test (VAT), Digit Span Forward and Backward], and produced appropriate but unacceptably slow performance in initial testing on the Simple Reaction Time test. Effective performance on the Symbol-Digit test also was produced by shaping instruction, without assistance from examiners, in small groups of residents of Taipei (Taiwan) and US children between the ages of 5 and 16.

Adolescent↗

PubMedDate not supplied

Computerized neurobehavioral testing: techniques for improving test instructions.

The development of new computer-administered neuropsychological tests has brought a renewed focus on the issue of written instructions. Designers and programmers often fail to take advantage of the display options and feedback potential available in modern computer systems to maximize the effectiveness of the instruction process. Guidelines from computer interface architecture and behavioral analysis are combined to present three principles for written instructions: precise language, attention focusing, and interactive instruction. A comparison of different instruction formats in the Symbol-Digit and Simple Reaction Time tests shows that the application of these principles can reduce training time without degrading performance.

Adult↗