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Biomedical subjects

O Israel

Publications and source records attributed to O Israel.

At least 91 records · Page 5Linked to original sources
PubMed1985

Tubular duplication of the jejunum and ileum lined entirely by gastric mucosa.

A 3-year-old boy who suffered from severe colicky abdominal pain is presented. Laboratory studies, including ultrasound, upper gastrointestinal films, and 99mTc-scan, were interpreted as normal. On exploration of the abdomen a tubular duplication of the small bowel was found. The duplication had a common mesentery with the normal bowel. By meticulous dissection the duplication was resected without interfering with the blood supply of the normal bowel. The entire duplication was found to be covered by gastric mucosa.

Abdomen↗
PubMed1985

24-Hour/4-hour ratio of technetium-99m methylene diphosphonate uptake in patients with bone metastases and degenerative bone changes.

The uptake of [99mTc]MDP in metastatic lesions of the vertebrae was compared with the uptake in normal vertebrae. The ratio of these lesion-to-nonlesion uptakes at 4 and 24 hr was called the 24-hr/4-hr ratio (TF ratio). A similar ratio was measured for lesions in the spine due to degenerative bone disease. Lesions in vertebrae with degenerative bone disease and treated metastases had a significantly lower TF ratio than lesions in vertebrae with untreated bone metastases. These findings suggest that the TF ratio might be a reliable method for separating metastatic lesions from degenerative changes in the vertebral column, and could be especially useful in cancer patients whose bone scans demonstrate a single lesion in the spine.

Adult↗
PubMed1985

Nuclear magnetic resonance imaging of liver hemangiomas.

Nine patients with cavernous hemangioma of the liver were examined by nuclear magnetic resonance imaging (MRI) with a 0.5 T superconductive magnet. Spin-echo technique was used with varying time to echo (TE) and repetition times (TR). Results were compared with 99mTc red blood cell (RBC) scintigraphy, computed tomography (CT), echography, and arteriography. Four illustrated cases are reported. It was possible to establish a pattern for MRI characteristics of cavernous hemangiomas; rounded or smooth lobulated shape, marked increase in T1 and T2 values as compared with normal liver values. It is concluded that, although more experience is necessary to compare the specificity with that of ultrasound and CT, MRI proved to be very sensitive for the diagnosis of liver hemangioma, especially in the case of small ones which may be missed by 99mTc-labeled RBC scintigraphy.

Adolescent↗
PubMed1985

Hydatid cyst of the liver rupturing into the biliary tract--mimicking acute cholecystitis on hepatobiliary scanning.

Two patients presenting with right upper abdominal colicky pain, jaundice, and fever had a hepatobiliary scan using Tc 99m HIDA. The scan was suggestive of acute cholecystitis and a space occupying lesion in the liver. On operation, liver echinococcosis, located in the right lobe rupturing into the biliary ductal system, was found. Intraoperative cholangiography revealed filling defects in the main biliary ducts. Exploration of the common bile duct disclosed daughter cysts and cystic debris. Acute cholecystitis or stones were not found. We conclude that in patients with a clinical picture and HIDA scanning compatible with acute cholecystitis and a space occupying lesion in the liver, the diagnosis of hydatid cyst of the liver which has ruptured into the biliary tract should be considered.

Acute Disease↗
PubMed1984

Technetium-99m-labeled red blood cell imaging.

Red blood cells labeled with 99mTc constitute a suitable intravascular agent for imaging of vascular abnormalities. Hemangiomas are characterized by low perfusion and a high blood pool. This "perfusion blood-pool mismatch," not encountered in other lesions, may help in the specific diagnosis of this tumor. This is particularly so in cavernous hemangiomas of the liver where three-phase 99mTc-labeled red blood cell scintigraphy should precede liver biopsy. Red cell scintigraphy also is useful for establishing the vascular nature of hemangiomas of the head and neck and the skin and for diagnosis of venous occlusion. Heat-damaged red blood cells provide a specific spleen imaging agent. This should be used when patients with suspected splenic pathology have equivocal colloid scintigraphy.

Adult↗
PubMed1984

The blood-tissue barrier of human brain tumors: correlation of scintigraphic and ultrastructural findings: concise communication.

Through the first 2 hr, uptake of [Tc-99m]pertechnetate and of Co-57 bleomycin were assessed in 29 brain tumors and were correlated with the ultrastructure of the tumor's capillary endothelium. No difference in uptake was found between the two tracers. Permeability of brain tumors to these agents was found to be governed by the same ultrastructural features that determine permeability in experimental brain tumors: the type of junction between contiguous endothelial cells in the capillaries. Meningiomas, which showed very high uptake of the radiotracers, demonstrated open or punctate junctions with short fusion of apposed membranes. They also showed a large number of pinocytotic vesicles and fenestrae. Capillaries of tumors without uptake had a small number of short tight junctions (less than 0.25 mu) between adjacent endothelial cells and a relatively large number of long junctions (greater than 0.5 mu). In intracerebral tumors that showed relatively high uptake, the reverse was true: most of the junctions were short and only a few long junctions were found. That uptake of [Tc-99m]pertechnetate and of Co-57 bleomycin depends on tumor capillary ultrastructure (which determines the permeability) suggests the possibility of the use of radiopharmaceuticals as in vivo indicators of tumor permeability. Brain scintigraphy may help to asses brain-tumor availability to non-lipid-soluble chemotherapeutic drugs.

Bleomycin↗
PubMed1981

Correlation between radionuclides uptake and ultrastructural features of tight junctions in the capillary wall of meningiomas.

The uptake of Tc-99m pertechnetate and Co-57 bleomycin and the ultrastructure of small blood vessels were studied in 10 cases of meningioma. When thin sections of 120 contact areas between adjacent endothelial cells were examined, 92% of the intercellular contacts contained one to three punctate tight junctions. Freeze fracture preparations revealed fascia occludens with one to four sealing strands. These findings are consistent with the high permeability the meningiomas displayed for both of the radiopharmaceuticals.

Capillaries↗
PubMed1981

Hydatid disease: the value of whole-body screening by scintigraphy with technetium-99m-labelled red blood cells.

Whole-body scintigraphy with 99Tcm-labelled red blood cells was performed in eight patients with hydatid disease. There was good correlation between these studies and other diagnostic procedures which included radiocolloid liver scintigraphy, liver ultrasound, body computed tomography and chest radiography. Whole-body scintigraphy with 99Tcm-labelled red blood cells appears suitable for screening patients with hydatid disease, many of whom have multiple organ involvement.

Adolescent↗
PubMed1981

Tc-99m-labeled red blood cells in the evaluation of vascular abnormalities.

Scintigraphy with Tc-99m-labeled red blood cells was used to evaluate five patients with suspected vascular abnormalities. The technique was useful for the imaging of large areas of the body and in obtaining multiple views. Conventional radionuclide angiography is of limited usefulness in such cases.

Adult↗
PubMed1981

Scintigraphy of hepatic hemangiomas: the value of Tc-99m-labeled red blood cells: concise communication.

Fourteen patients with hepatic hemangiomas were evaluated by Tc-99m colloid scintigraphy and Tc-99m RBC angiography, including flow studies and early and delayed static studies. On colloid scintigraphy, the liver appeared enlarged, with single or multiple focal defects. During the flow and early static Tc-99m RBC studies, the lesions showed poor perfusion and were filled only partially or not at all. Delayed Tc-99m RBC studies demonstrated the whole extent of the lesion and all the lesions when multiple hemangiomas were present. A flow study showing decreased perfusion and a late blood-pool study showing increased local blood volume appear characteristic of hemangiomas. Liver biopsy should not be attempted in such cases.

Angiography↗
PubMed1979

Scintigraphy of abdominal masses with 99mTc-labeled red blood cells.

Scintigraphy with 99mTc-labeled red blood cells was performed in five patients for demonstration of normal anatomy and in 18 patients for evaluation of suspected or apparent space-occupying abdominal lesions. In 14 cases of abdominal lesions, the study demonstrated the extent, vascularity, and relation of the lesion to neighboring organs. We found the method was primarily useful for evaluating cases of retroperitoneal tumor and vascular malformation.

Abdomen↗
PubMed1978

Perfusion vascularity mismatch in liver hemangiomas.

Perfusion defect in the dynamic study and slow filling of the lesion by a blood pool agent were observed in three cases with large cavernous hemangiomas of the liver. This finding is explained by the low perfusion and the large blood volume of cavernous hemangiomas. When such a lesion is suspected a late blood pool study should be performed in order to demonstrate the true vascularity of the lesion.

Angiography↗