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Biomedical subjects

O Ishida

Publications and source records attributed to O Ishida.

At least 109 records · Page 6Linked to original sources
PubMed1987

Quantitative analysis of inner ear anomalies by high resolution CT scanning of the temporal bone.

High resolution CT-scanning of the temporal bone revealed malformations of the labyrinthine capsule in 50 ears in our clinic from November 1980, to the end of 1984. Detailed assessment of the nature and extent of the abnormality allowed each ear to be awarded a mathematical score. Using statistical methods, the score was then correlated with the patient's hearing in that ear. By this method it was possible, with an 80% chance of being correct, to allocate a patient into one of two groups, i.e. partial deafness or total deafness.

Adolescent↗
PubMed1985

Heterogeneity of cutaneous T-cell lymphoma. Phenotypic and ultrastructural characterization of four unusual cases.

This study characterized, by means of immunocytochemistry and electron microscopy, four cases of "unusual" cutaneous T-cell lymphoma (CTCL) other than classical mycosis fungoids and Sézary syndrome. Cases 1, 2, and 4 were diffuse lymphoma of a pleomorphic type, and Case 3 was of a mixed type. Case 4 shared a feature common to pagetoid reticulosis. A fairly large number of inflammatory cells were seen in Cases 1, 3, and 4. Functionally, the neoplastic cells of Cases 1, 3, and 4 were of a helper/inducer T-cell subset, whereas those of Case 2 were of a suppressor/cytotoxic T-cell type. Epidermotropic cells with pagetoid growth in Case 4 failed to show these specific surface phenotypes, although they still retained pan T-cell markers. Neoplastic large or intermediate-sized cells revealed a marked difference in the development of cytoplasmic organelles and their nuclear profiles, ranging from a few simple indentations (Cases 2 and 3) to forms with many deep indentations (Case 1) and highly cleaved shapes (Case 4). All of these cells, however, possessed dense-cored granules located in a portion of the cytoplasm. This study indicated the clinicopathologic and immunologic heterogeneity of CTCL, which may be classified, according to the reactivity with monoclonal antibodies and the fine structural features, into subtypes that correspond to functionally distinct subsets of T-cells and their stages or types of differentiation.

Adult↗
PubMed1983

Combined chemical and electron microscopic studies of pheomelanosomes in human red hair.

This study clarified the fine structure of pheomelanosomes in human red hair by quantifying the contents of pheomelanin and eumelanin and by identifying the fine structure of melanocytes and melanosomes based on their melanogenesis type in follicles. Out of 5 red-haired subjects, 3 were found to exhibit pheomelanogenesis in follicles, while the remaining 2 were found to have a mixed type melanogenesis of pheomelanin and eumelanin. Melanocytes in the pheomelanic follicles contained spherical melanosomes which revealed sequences of development identical to those seen in the pheomelanosomes of mice and guinea pigs. In contrast, the follicles of mixed type melanogenesis contained 2 different populations of melanocytes, i.e., one with synthesis of spherical melanosomes such as seen in the pheomelanic follicles and the other with synthesis of ellipsoidal-lamellar (filamentous) granules of eumelanosome form. It was concluded that (a) visual differentiation of hair color does not always reflect the melanogenesis type in human red hair, (b) chemical analysis of melanogenesis type corresponds well to the fine structural differentiation of eumelanosomes and pheomelanosomes, and (c) human pheomelanosomes are spherical granules with microvesicular (vesiculoglobular) and proteinaceous matrices on which melanin deposition is spotty and granular.

Adult↗
PubMed1982

Normal anatomy of the pyloric branch and its diagnostic significance in angiography.

The course of the pyloric branch, usually arising from the distal end of the gastroduodenal artery, was investigated using angiography of 15 specimens and of 200 patients. It was found that the pyloric branch usually supplies the greater curvature of the gastric antrum and of the duodenal bulb, pylorus and the oral portion of the descending duodenum, although there may be some variations. A correct diagnosis of the primary site and extent of a malignant tumor in the gastric antrum, duodenum or pancreatic head, needs a thorough knowledge of the normal anatomy of the pyloric branch.

Angiography↗
PubMed1982

An autopsy case of primary hepatoma associated with an oral contraceptive.

Primary hepatoma was found in a 38-year-old female who had been using an oral contraceptive for 28 months. Histologically the hepatoma was a well-differentiated hepatocellular carcinoma. Alpha-fetoprotein was not increased and tests for HBS antigen was negative. Carcinoembryonic antigen was elevated remarkably before death. The findings of hepatic arteriography and peritoneoscopy suggested metastatic tumors of the liver rather than primary hepatoma. During the course of the disease, phlebothrombosis occurred and spread widely in the lower left limb. The observation of erythrocytosis indicated the presence of a tumor producing erythropoietin or an erythropoietin-like substance.

Adult↗