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O Hikosaka

Publications and source records attributed to O Hikosaka.

89 records · Page 5Linked to original sources
PubMed1980

Inhibitory connections of nystagmus-related reticular burst neurons with neurons in the abducens, prepositus hypoglossi and vestibular nuclei in the cat.

Action potentials of inhibitory burst neurons (IBNs) were extracellularly recorded in the pontomedullary reticular formation in the cat. These neurons were identified by their burst activity coincident with the quick inhibitory phase of the contralateral abducens nerve during vestibular nystagmus and by their antidromic activation from the contralateral abducens nucleus. During extracellular recording from the soma of single IBNs, another electrode for microstimulation was systematically tracked throughout the brain stem. For each IBN investigated, the effective sites for antidromic activation were invariably found in the contralateral abducens, prepositus hypoglossi, medial vestibular nuclei and the area ventral to the prepositus hypoglossi nucleus. Stimulation of neither the ipsilateral brain stem nor the oculomotor nuclei evoked antidromic responses in IBNs. Extracellular spikes of single IBNs and neurons in the overlying projection area were recorded simultaneously. Their correlation was examined by using peri-spike time histograms. Shortly after the spikes of single IBNs, the activity of motoneurons and internuclear interneurons in the abducens nucleus, and of type II neurons in the prepositus hypoglossi and vestibular nuclei, was depressed. Connections of IBNs with ipsilateral medial rectus motoneurons were studied by spike-triggered averaging of membrane potentials of the motoneurons and action potentials of the medial rectus nerve. Single IBN spikes induced a di- or polysynaptic disfacilitation in the motoneurons. This disfacilitation was concluded to be mediated by some of the above-described interneurons which were directly inhibited by IBNs. Their depressant effect on medial rectus motoneuronal spike activity was comparable to that on the spike activity of contralateral abducens motoneurons.

Abducens Nerve↗
PubMed1980

Spatio-temporal patterns of pre- and postsynaptic inhibition induced by primary afferent activation in the trigeminal sensory nucleus in cats.

Spatio-temporal patterns of pre- and postsynaptic inhibition were studied in the trigeminal spinal nucleus oralis of cats by means of systematic electrical stimulation of the facial skin. Stimulation of the facial skin induced an EPSP-IPSP sequence in trigemino-thalamic relay cells (TRC). The IPSP was depressed by picrotoxin but was resistant to strychnine. The largest IPSP was evoked from the center of the excitatory area, where stimulation induced the largest EPSP and spike potentials at the lowest intensity in the same TRC. The amplitude of the IPSP decreased with increasing distance from the center in parallel with that of the EPSP. In the great majority of trigeminal primary afferent fibers, the largest primary afferent depolarization (PAD) was not evoked from the center of the excitatory area, where the threshold for spike generation was lowest, but from the adjacent points on the face. Spike activities in a trigeminal primary afferent fiber did not evoke any detectable PAD in itself. The duration of the PAD was definitely longer than the IPSP in TRC. However, the temporal distribution of the peak of PADs was very similar to that of the EPSP in TRC. Inhibition was evoked in glutamate-induced spike discharges of TRC by stimulation of the points on the face, which were located close to the center of the excitatory area of the TRC. However, the afferent inhibition of both spontaneous and peripherally induced spike discharges of TRC outlasted the postsynaptic inhibition. Thus, the late phase of the afferent inhibition is most probably due to presynaptic inhibition. Presynaptic inhibition, together with postsynaptic inhibition, would be involved also in the early phase of afferent inhibition through its mutual inhibitory organization.

Afferent Pathways↗
PubMed1980

Postsynaptic inhibition underlying spike suppression of secondary vestibular neurons during quick phases of vestibular nystagmus.

Synaptic mechanisms of spike suppression of vestibular neurons during quick phases of vestibular nystagmus were investigated by intracellular recording in the rostrolateral part of the cat medial vestibular nucleus. When repetitive spike discharges of vestibular neurons were abruptly suppressed at the quick phase, the membrane potential shifted steeply in the hyperpolarizing direction. After the commissural IPSP was inverted into depolarization by intracellular injection of Cl-ions, the hyperpolarizing deflection of the membrane potential at the quick phase was also inverted into a depolarizing potential. The results indicate that an abrupt generation of IPSPs in vestibular neurons underlies the quick phase suppression of spike activity in these neurons.

Abducens Nerve↗
PubMed1978

Direct inhibitory synaptic linkage of pontomedullary reticular burst neurons with abducens motoneurons in the cat.

1. Unit spikes of burst neurons were extracellularly recorded in the pontomedullary reticular formation of the cat. These neurons were identified by their burst activity coincident with the quick inhibitory phase of the contralateral abducens nerve during vestibular nystagmus and their antidromic activation from the contralateral abducens nucleus. 2. When the extracellular field potentials in and near the abducens nucleus were triggered by spikes of a contralateral burs neuron, the averaged potential consisted of an early di- or triphasic spike and a late slow positive wave. The early spike was an action current caused by impulses conducting along the axon of the burst neuron. 3. The action potentials of a contralateral burst neuron. 3. The action potentials of a contralateral burst neuron were employed to trigger a post-spike average of the membrane potential of abducens motoneurons. Then unitary IPSPs with monosynaptic latencies were revealed. This provided direct evidence that the burst neurons are inhibitory in nature. The amplitudes of unitary IPSPs ranged from 18 to 220 mu V. Each inhibitory burst neuron branched widely in the abducens nucleus and was estimated to make inhibitory connections with approximately 60% of the motoneuron pool. 4. The post-spike average of compound potentials of the abducens nerve triggered by action potentials of contralateral single inhibitory burst neurons revealed inhibition of spike activity with latencies and time courses compatible with those of unitary IPSPs in motoneurons. The inhibition was observed with all inhibitory burst neurons tested.

Abducens Nerve↗
PubMed1978

Diagnostic and therapeutic considerations of myogenic tumors of the duodenum.

Three cases of duodenal myogenic tumor are described in detail. All the three were surgically treated and the final diagnoses were histologically established. The three consisted of two leiomyomas and one leiomyosarcoma. To make clinical diagnosis, roentgenologic, endoscopic, and angiographic examinations were empolyed. The selective angiography was more reliable than endoscopic biopsy to make a differential diagnosis whether a tumor was benign or malignant. Surgical procedures were required not only for malignant myomatous lesions but also for benign lesions because the latter also produce a high incidence of hemorrhage from ulceration of the tumor. Out of the three cases, one was successfully treated by enucleation but the other two were undergone more extensive surgery such as a Whipple's procedure or wide resection of the duodenal wall with side-to-side duodenojejunostomy. Operative techniques are discussed in detail basing on the biological characteristics, location, and size of the tumor.

Duodenal Neoplasms↗