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Biomedical subjects

O H Gyde

Publications and source records attributed to O H Gyde.

34 records · Page 2Linked to original sources
PubMed1978

Androgen trial in renal anaemia.

A double blind cross-over trial of Nandrolone decanoate (Decadurabolin) was carried out in 27 patients with anaemia due to end stage renal disease, stabilised on regular haemodialysis. Sixteen patients completed the study, the other patients being excluded from the final analysis for a variety of reasons including side effects related to the androgen. There was no sustained significant rise in haemoglobin concentration or in red cell mass. Erythropoietin levels did not alter, they were within or below the normal range, but were lower than would be expected for the degree of anaemia. A majority of patients reported increased well-being including exercise tolerance, appetite and libido. Voice changes and hirsutism were noted, mainly in the females. Instability of anticoagulant therapy and abnormalities in liver function were found in some patients. The benefits, though real, were restricted essentially to the improvement in subjective findings and were unrelated to laboratory measurements. These effects might be obtained with a lower dosage of the drug.

Adult↗
PubMed1977

G gamma delta beta thalassaemia and g gamma HPFH (Hb Kenya type): comparison of 2 new cases.

Two new cases of G gamma delta beta thalassaemia and G gamma HPFH (Hb Kenya type) have been characterised in detail and compared with regard to haematological data, globin chains biosynthesis, and intracellular distribution of Hb F. The similarities and differences between these two conditions are discussed in relation to the possible underlying defects at the molecular level and to the control of the gamma delta beta gene complex in general.

Adult↗
PubMed1966

Occurrence of lymphopenia in heart failure.

The incidence of lymphopenia and eosinopenia in 10 patients admitted to hospital in heart failure was compared with that in 11 ;cold' admissions and 10 with acute diseases admitted via the Casualty Department. Plasma cortisol determinations were made simultaneously. A significant difference was found between the heart failure group and the ;cold' controls in respect of lymphopenia, eosinopenia, and cortisol levels. The ;acute' control patients showed an overlap with both groups. It is concluded that this lymphopenia is part of a response to stress.Seventy-two hours after admission there was no significant change in these values although the figures suggest the beginning of a return to normal.

Aged↗
PubMedDate not supplied

Platelet aggregation and coagulation factors in insulin dependent diabetics with and without microangiopathy.

Abnormalities of platelet aggregation and coagulation have been reported in insulin dependent diabetes mellitus (IDDM), although there is controversy concerning their relationship to microangiopathy. We have studied platelet function and haemostasis in 55 patients with IDDM, 23 without, 14 with mild (background retinopathy) and 18 with severe (proliferative retinopathy, or background retinopathy plus proteinuria) complications. Studies were done on 2 occasions 8 weeks apart and the results compared with 28 control subjects. There was evidence of increased in vivo platelet aggregation in the diabetic group v controls shown by raised values of beta-thromboglobulin (61 +/- 42, mean +/- SD, v 18 +/- 14 micrograms/ml, p less than 0.001), platelet factor 4 (62 +/- 76 v 14 +/- 11 micrograms/ml, p less than 0.01), and platelet micro-aggregates (20 +/- 16 v 12 +/- 11%, p less than 0.01). There was no significant difference in fibrinogen and fibrinopeptide A levels, nor in 'in vitro' tests of platelet aggregation between the groups. Dilute whole blood clot lysis time was increased in the diabetic group v controls (6.4 +/- 2.6 v 4.8 +/- 0.5 hours, respectively, p less than 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMedDate not supplied

Platelet behaviour and haemostatic variables in type 1 (insulin-dependent) diabetic patients with and without albuminuria.

Abnormalities of haemostasis have been implicated in the development of both large and small vessel disease in diabetes. Platelet behaviour and coagulation factors were studied in 28 non-diabetic control subjects and 81 Type 1 diabetic patients with different degrees of albuminuria. Twenty-four (30%) patients had macro- or micro-albuminuria. These patients had elevated levels of beta-thromboglobulin compared with normo-albuminuric patients and control subjects (macro-albuminuric 113 (range 60-314), micro-albuminuric 88 (50-220), normo-albuminuric 55 (13-273), control 52 (18-210) micrograms l-1, p less than 0.001). Similar results were found for platelet factor 4 (macro-albuminuric 57 (9-350), micro-albuminuric 78 (12-205), normo-albuminuric 10 (2-135), control 9 (3-95) micrograms l-1, p less than 0.001). There were decreased beta-thromboglobulin:platelet factor 4 ratios in the albuminuric patients compared with control subjects and normo-albuminuric patients (p less than 0.001). There is abnormal platelet activity in Type 1 diabetic patients with elevated albumin excretion rates.

Adult↗
PubMedDate not supplied

Erythropoietin in children with chronic renal failure on dialytic and non-dialytic therapy.

The serum values of erythropoietin and relationship with hemoglobin was studied in 29 children with chronic renal failure. 10 of the patients were receiving continuous ambulatory peritoneal dialysis (CAPD), 12 were on regular haemodialysis treatment (RHT) and 7 children were not on any form of dialysis treatment (ND). Serum erythropoietin was estimated using fetal mouse liver bioassay. The mean serum erythropoietin concentration in the three groups of patients were within the normal range but were inappropriately low for the degree of anemia (CAPD 19.6 +/- 8.0 mu/ml, RHT 25.7 +/- 13.2 mu/ml, ND 21.9 +/- 11.0 mu/ml. The haemoglobin value of (7.0 +/- 1.3 gm/dl) in the CAPD group was higher than in the RHT group (6.4 +/- 1.5 gm/dl), but this difference was not statistically significant (p greater than 0.1). In the non-dialysed patients, the mean haemoglobin value was 11.32 +/- 2.31 gm/dl and this was significantly higher than the values in the CAPD and RHT patients (p less than 0.05). No correlation was found between serum erythropoietin and haemoglobin in the three groups of patients.

Adolescent↗