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Biomedical subjects

O Greisen

Publications and source records attributed to O Greisen.

At least 37 records · Page 2Linked to original sources
PubMed1985

Inverted papillomas of the nose and the paranasal sinuses.

A series of 21 patients with inverted papillomas of the nose and/or the paranasal sinuses is presented. In 19 patients the tumour arose from the lateral nasal wall or paranasal sinuses, in 2 it arose from the nasal septum. Nine patients had been previously treated by nasal polypectomy. None of the patients with recurrences after primary surgical treatment showed any evidence of a progression from benign to malignant lesions. Only 14% of the patients suffered from recurrence, and it seems likely that this is because extensive surgical extirpation was recommended as primary treatment in most cases. We feel justified in recommending early and radical surgery.

Adult↗
PubMed1984

Vocal cord sulcus.

Vocal cord sulcus is a congenital condition consisting of a furrow on the medial edge of the vocal cord. It is most often bilateral but may be unilateral. The symptoms are a hoarse and breathy voice due to incomplete closure of the vocal cords. The present series comprises 15 patients found among 1,400 patients with voice and speech disorders. The condition is often overlooked and regarded as part of a primary functional hyperkinetic voice disorder. By close inspection the furrow can often be seen by indirect laryngoscopy. In many cases, however, microlaryngoscopy under general anaesthesia should be performed, but the furrow is only detected if a search is made for it. The condition is often found in younger patients, probably due to the fact that the sulcus is difficult to detect in older patients who have developed severe organic changes in a effort to overcome the incomplete closure of the glottis.

Adolescent↗
PubMed1984

Fine-needle aspiration biopsy of the thyroid gland.

Fine-needle aspiration biopsy is a diagnostic procedure used routinely in the evaluation of patients referred with a thyroid swelling. The technique and the results in our series of 233 patients, which included 39 carcinomas, are presented. A relatively high diagnostic specificity of 81% was found, whereas the diagnostic sensitivity was considerably lower (58%). It is concluded that fine-needle aspiration biopsy is a valuable diagnostic procedure in the preoperative assessment of patients with thyroid swellings. A definitive treatment, however, must never be based entirely on the results of a fine-needle aspiration biopsy. It is concluded that the results can be improved if the procedure is performed by a few highly skilled clinicians and pathologists.

Adenoma↗
PubMed1984

Thyroid surgery.

In a 5-year period we treated 233 patients referred to us with a thyroid swelling. Among them, 39 patients (17%) had a malignant tumor. Seventy-eight percent of the patients were women. The preoperative examination procedure is discussed. Preoperatively, recurrent nerve palsy was found in 2.6% of patients with benign tumors and in 28% of patients with malignant tumors. The histologic features of the benign and the malignant tumors are described. The operative procedure in the benign group consisted of enucleation, resection, or lobectomy. In the patients with malignant tumors a radical operation was performed, consisting of lobectomy (unilateral or bilateral) when possible, eventually combined with radical neck dissection. The operative complications are discussed.

Adolescent↗
PubMed1982

Treatment of zygomatic fractures: a follow-up study of 105 patients.

One hundred and five patients with zygomatic fractures are presented. The main cause of the fracture was violence, followed by traffic accidents, fall and sport. In more than 25% of the cases, the fractures were accompanied by another fracture of the facial skeleton, viz maxillary, mandibular and nasal fractures. In severe cases of traffic accidents there were associated fractures in more than half of the cases. The follow-up study showed visible asymmetry of the face in 17 patients and sensory disturbances in 37 patients. We did not find the X-ray subdivision by Knight & North useful in the evaluation of the stability of the fractures. As a method of choice in cases of dislocated zygomatic fractures, we used reposition by the method of Gillies and in cases of instability this reposition was combined with internal wiring, reconstruction of the orbital floor and antral packing. An active attitude towards reconstruction of the orbital floor is recommended.

Adolescent↗
PubMed1981

Diagnostic value of brush biopsy in suspected bronchial carcinoma with the use of the flexible fibre bronchoscope.

In a 12-month period, brush biopsy through a fibreoptic bronchoscope was performed on 125 consecutive patients who were clinically or radiographically suspected of lung cancer. Of the patients, 62 appeared to have lung cancer. Cytological analysis of the brush-biopsy specimens was positive in 69%. A total of 58% had positive biopsy, and 58% had cancer cells in the bronchial secretion aspirated during the bronchoscopy. Thirty-five per cent had positive mediastinoscopy. When the methods of examination were combined, the diagnosis could be established in 90% of the patients. The study shows that brush biopsy and cytological analysis, in combination with the other methods of examination, increase the diagnostic sensitivity in bronchoscopically visible tumours. In bronchoscopically invisible tumours, brush cytological analysis, together with the study of bronchial secretion and fine-needle puncture, is the most effective diagnostic method. The diagnostic possibilities can presumably be further improved by the use of fluoroscopic control in two places during the bronchoscopy.

Adult↗
PubMed1981

Peritonsillar abscess. I. Cases treated by incision and drainage: a follow-up investigation.

The purpose of the present follow-up investigation was to evaluate the indications for tonsillectomy à chaud in the presence of a peritonsillar abscess. Of 76 consecutive patients treated for peritonsillar abscess, 45 were treated by incision and drainage, and no tonsillectomy à froid was planned. None of these patients had had previous peritonsillar abscess or recurrent tonsillitis; therefore tonsillectomy was not indicated. A follow-up investigation including 44 of these 45 patients showed that among patients under 30 years of age, 63 per cent had another peritonsillar abscess or recurrent tonsillitis during he follow-up period. Within an average period of 3 years, 41 per cent in this group underwent tonsillectomy. Among patients older than 30 years only 12 per cent had recurrent tonsillar symptoms, and in no case was tonsillectomy performed. The indication for tonsillectomy à chaud is discussed, and the method is recommended as a routine in peritonsillar abscess in patients under 30 years old, whereas conservative treatment with incision and drainage is recommended in patients older than 30 years if the patient has had no previous peritonsillar abscess or recurrent tonsillitis.

Adolescent↗
PubMed1981

Peritonsillar abscess. II. Cases treated with tonsillectomy à chaud.

The treatment of a peritonsillar abscess by tonsillectomy à chaud obviously offers advantages over the more conservative treatment with incision, daily dilatations and possibly a later tonsillectomy. The patient avoids the painful drainage of the abscess with daily dilatations. Technically, the operation is easier to perform than later on when fibrosis has developed. The operative complications are not greater than in elective tonsillectomy, and there is no risk of spread of the infection when the patient is treated with antibiotics.

Adolescent↗
PubMed1975

Aberrant course of the facial nerve.

In our patient the facial nerve was situated in the external bony ear canal without bony protection just below the skin in the lower part of the external ear canal 2 to 3 mm lateral to the tympanic membrane. This abnormal position involves a greate risk of damage to the facial nerve by incisions in the ear canal prior to surgical intervention of the middle ear.

Ear Canal↗
PubMed1975

Middle ear reflex activity in the startle reaction.

By means of extratympanic phonometry, the middle ear muscular reflex activity in the startle reaction was measured in a control series, in patients with otosclerosis and in patients with operation cavaties without a functioning tensor tympani muscle. In comparison with the stapedius reflex, the startle reflex was found to be much more variable regarding latency, amplitude, and configuration. It was characterized by pronounced fatigue and a high alertness dependence. The period of latency was about 60 msec. It was possible to elicit a distinct startle reflex in operation cavities without a functioning tensor tympani muscle, probably because of contraction of the Eustachian tube muscles.

Attention↗
PubMed1975

Reversible hearing loss in tumours of the cerebello-pontine angle.

A survey of the literature concerning reversible hearing loss in tumours of the cerebello-pontine angle is presented together with two additional cases. After removal of one meningioma and one epidermoid tumour, respectively, the abolished acoustico-vestibular function returned in both cases. The pre-requisites for the restoration of hearing are discussed.

Adult↗
PubMed1975

Deoxyribonucleic acid content in the laryngeal mucosa with special reference to polyploid cell nuclei.

The DNA content was measured by microphotometry in morphologically normal squamous epithelium of the larynx, in hyperplastic epithelium of the vocal cords and in invasive squamous-cell carcinoma. The average nuclear DNA content in the squamous-cell carcinoma was elevated in comparison with that of normal epithelium, and the values showed a much wider dispersion. During premitotic DNA synthesis, the nuclear content of DNA is doubled. Polyploid cell nuclei with a nuclear DNA content of more than twice the model value (the stem cell of the tumour) are therefore a distinct sign of an abnormally elevated content of DNA. In morphologically normal epithelium no polyploid cell nuclei were revealed, while such nuclei were present in all cases of invasive squamous-cell carcinoma. Polyploid cell nuclei were found in six out of 20 patients with hyperplasia of the epithelium of the vocal cords. Among these six patients, manifest invasive carcinoma developed inthree, carcinoma in situ in one, while the condition remained benign in two, probably because the pathological tissue was completely removed. The presence of polyploid cell nuclei should thus arouse a strong suspicion of malignancy and calls for close supervision of the patient.

Carcinoma, Squamous Cell↗