Biomedical subjects
Publications and source records attributed to O G Rodman.
Cutaneous leiomyomas are rarely encountered at birth. In their usual form they appear as discrete dermal papules or nodules with a pink or brown discoloration of the overlying skin. We examined an infant with an unusual mass attached to the right heel at birth. Histologically, the lesion was a leiomyoma. It apparently represented a bizarre proliferative anomaly of smooth muscle occurring during fetal development.
A 70-year-old woman with the multiple hamartoma syndrome is described. Diagnosis was based on the clinical presentation and histopathologic examination of cutaneous trichilemmomas. The case is reported to document the association of Cowden's disease with non-Hodgkin's lymphoma. This is the first known report of the occurrence of trichilemmomas in the sacral area. The literature concerning the association of the multiple hamartoma syndrome with malignancy is reviewed.
A 21-year-old man presented with a 6-year history of episodic localized hyperhidrosis on the back of his hands. Results of the neurologic examination were normal. Profuse sweating of the affected skin was elicited by exercise, raising core temperature, direct heat, and intradermal injections of cholinergic drugs. Examination of the affected skin by electron microscopy and light microscopy with special stains and enzyme methods revealed prominent hyperplasia of otherwise normal eccrine sweat glands and ducts and increased surrounding stromal hyaluronic acid.
The clinical spectrum of human T cell lymphotropic virus type III (HTLV-III) disease is associated with myriad cutaneous findings, commonly of infectious origin. A clinically characteristic, yet histologically nonspecific, papular eruption was observed in seven of thirty-five patients followed up for HTLV-III disease (acquired immunodeficiency syndrome and the related complex). Noncoalescing 2- to 5-mm skin-colored papules of the head, neck, and upper trunk typify the lesions. Histologically, a chronic perivascular infiltrate of mononuclear cells was regularly present. The eruption was often, but not always, pruritic. The clinical course was chronic. Many patients had persistent lesions for more than 9 months; however, the number of papules tended to wax and wane with time. Although the cause of this eruption is unknown, it is sufficiently distinct and frequent to be recognized by clinicians as a cutaneous sign of human retrovirus infection.
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A patient with chronic myelogenous leukemia (CML) in blast crisis experienced a peculiar painful eruption on his left lower extremity during the preterminal phase of his disease. The lesion was characterized by tender, edematous, purpuric infiltration which resembled stasis dermatitis clinically. Dermatopathologic examination demonstrated leukemia cutis.
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Pigmentary demarcation lines are borders of abrupt transition between more deeply pigmented skin and that of lighter pigmentation. Two patients developed these lines on the lower extremities during pregnancy.
A 22-year-old black male patient developed discrete, exquisitely painful bilateral plantar lesions. Histologic examination revealed a cutaneous groove filled by a keratin plug (cornoid lamella). There is focal absence of granular layer underlying this defect. The differential diagnosis of this lesion, familiar to podiatrists but relatively unknown to dermatologists, is discussed.
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Syringomas occur quite commonly, but the occurrence of widespread lesions is rare. A patient is described with the unique coincident findings of eruptive generalized syringomas associated with an unusual microscopic preponderance of clear cells.
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All participants with a baseline print score of greater than 1 demonstrated reduced sweating for up to six weeks following treatment with the Drionic device. Because of experimental design flaw, similar results were not obtained from those participants producing a baseline sweat print of 1. Therefore, the impression from these results is that, while not completely supported by objective data, it is possible to substantiate the subjective information related by patients in the control of hyperhidrosis.
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Usually occurring on the mid-face, especially on the nose, trichostasis spinulosa occurs more commonly in young, adult black women. The lesions of trichostasis spinulosa resemble open comedones (blackheads). It may be treated with tweezing, dipilatory wax, and topical retinoic acid.