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Biomedical subjects

O G Prokof'eva

Publications and source records attributed to O G Prokof'eva.

5 recordsLinked to original sources
PubMed1980

[Potential oncogenic action of the RNA isolated from rat lymphosarcoma].

From the tissue of the transplantable strain of rat lymphosarcoma, using phenol technics, a total RNA (sedimentation constants 31,5S; 19,0S; 6S) and chromosome-nuclear mRNA were isolated. The preparations contained up to 10% of protein. Nucleic acids (in a dosage of 10 mg RNA) were given by single intraperitoneal injections to 2 month-old rats. The animals showed a 180% increase of the lymphatic neoplasms yield when injected both total RNA and mRNA. Transplantation into newborn rats of the rat lymphocytes, treated in vitro by the total RNA preparations, failed to yield such a significant increase in the occurrence of neoplasms. A molecular weight of RNA fragments was similar to that in the experiments on transfection by nucleic acids, isolated from tumors of viral etiology.

3,3'-Dichlorobenzidine↗
PubMed1976

[Carcinogenicity of fuchsin derivatives].

White noninbred rats and linear mice were injected leucoparafuchsine and leucofuchsine isomers subcutaneously and received perorally during the whole life period, while in the experiments on mice--also by means of cutaneous application. The injection of leucoparafuchsine in rats and mice CC57Br resulted in the increased development of hemopoietic system tumors. Leucofuchsine isomers injected in rats and mice C3HA gave rise to the appearance of renal tumors in these animals and caused more frequent development of hepatic and pulmonary neoplasms in mice. In leucoparafuchsine injections the rate of tumors incidence was 35% in rats and in mice--20%, in the experiments with leucofuchsine isomers--33% and 40% accordingly. The results of the experiments evidence an insignificant blastomogenic effect of the compounds under study.

Adenofibroma↗