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Biomedical subjects

O Fyrand

Publications and source records attributed to O Fyrand.

47 records · Page 3Linked to original sources
PubMed1977

Immunofluorescence studies for immunoglobulins and complement C3 in synovial joint membranes in psoriatic arthritis.

Synovial tissues from fifteen patients with psoriatic arthritis were investigated with direct immunofluorescence staining for immunoglobulins (IgG, IgA, and IgM) and from eigth patients for complement component C3. As control groups, there were synovial tissues from seven patients with seropositive rheumatoid arthritis and five patients with meniscal tears. In psoriatic arthritis, immunoglobulins were found in plasma cells in 93% of the cases, always with the presence of IgG (93%) but also with IgA (47%) and IgM (7%). C3 could not be demonstrated. In seropositive rheumatoid arthritis IgG was demonstrated in all patients (100%), often together with IgA (43%) and IgM (57%). C3 was found in all of these patients. In patients with meniscal tears neither immunoglobulins nor C3 could be found. The present findings indicate immunological activity in synovial membranes in psoriatic arthritis. The low amount of IgM and the lack of C3 suggest a difference compared to seropositive rheumatoid arthritis.

Arthritis↗
PubMed1977

Studies on cold insoluble globulin in dermatological patients. II. Its immunochemical quantitation in citrated plasma in a group of unselected dermatological inpatients.

Cold insoluble globulin (CIG) is the main non-clottable protein of heparin precipitable fraction from dermatological patients. CIG is a glycoprotein with a molecular weight of about 440 000. It is found on cell membranes on fibroblasts and is a normal protein of human plasma and serum. Levels of CIG in citrated plasma are sex- and age-dependent, but the origin and its physiological significance is unknown. In plasma of 294 dermatological patients, levels of CIG were elevated in eczema contactum allergicum (males and females 30-49 years), psoriatic arthritis (females 50 years and above) and were depressed in dermatitis herpetiformis (males 30-49 years).

Adult↗
PubMed1977

Deposition of fibrinogen (FR-antigen) in skin diseases. III. Synovial joint membranes in psoriatic arthritis.

Synovial joint membranes obtained by synovectomy in open bloodless fields were examined for FR-antigen (fibrinogen/fibrin-related antigen) in 15 patients with psoriatic arthritis (ps.a.) and in a control group of 5 patients with meniscal tears. All frozen and paraffin sections from ps.a. demonstrated FR-antigen at the synovial lining. In the tissue it was located at the surface and in cytoplasm of the superficial synovial cells. In the control group, FR-antigen was present in all frozen samples as a thin layer at the synovial lining surface, but absent in the paraffin sections. The presence of FR-antigen may contribute to the further development of the Inflammatory changes of the arthritis.

Antigens↗
PubMed1975

Deposition of fibrinogen (FR-antigen) in skin diseases. I. Psoriasis vulgaris and Psoriasis arthropathica (with special reference to heparin-precipitable fraction).

Twenty-five in-patients with psoriasis arthropathica (ps.a.) and 18 in-patients with psoriasis vulgaris (ps.v.) were examined for cryofibrinogen as heparin-precipitable fraction (HPF), for total fibrinogen in plasma and by immuno-fluorescence (IF) technique for FR-antigen in tissue sections of affected and unaffected skin. A control group of 14 in-patients with various non-psoriatic dermatoses were examined with if for FR-antigen in unaffected skin. Pathological quantities of HPF were found in 6% in ps.v. and in 48% in ps.a. Total fibrinogen in plasma was normal in ps.v. (365 mg%), and moderately elevated in ps.a. (471 mg%). In psoriatics, FR-antigen was found in unaffected skin ps.v. in 50%, in ps.a. in 72%. In affected skin, the figures were 67% and 84% respectively. No direct relationship could be found between the incidence and the degree of HPF, and depositions of FR-antigen in the tissue sections in the skin at the time of the examination. In the control group, no FR-antigen could be found in unaffected skin, except in one case of acne cystica, with traces of FR-antigen in a few areas of the tissue section.

Adult↗
PubMed1975

Deposition of fibrinogen (FR-antigen) in skin diseases. II. Pustulosis palmaris et plantaris (with special reference to heparin-precipitable fraction).

Ten out-patients with pustulosis palmaris et plantaris were examined with direct immunofluorescence (IF) technique for deposition of fibrinogen, fibrin or its degradation products (FR-antigen) in affected and unaffected skin, together with heparin-precipitable fraction (HPF), cryoglobulin and total plasma fibrinogen in the blood. FR-antigen was found in all cases in affected skin as a uniform pattern of a continuous ramification below the dermo-epidermal junction. This IF picture was absent in unaffected skin, but in other parts of the dermis in affected and unaffected skin, scattered streaks of IF could be seen. In one case, however, unevenly distributed IF was found in unaffected skin in the junction area. The scattered IF was also present in a minor degree in affected and unaffected skin in a control material of other dermatoses. Only one patient had slightly elevated values of HPF (0.33 mg/ml). Total plasma fibrinogen was insignificantly elevated, and no cryoglobulin could be found.

Adult↗