Epinephrine and the genesis of hypertension.
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Biomedical subjects
Publications and source records attributed to O Frankl.
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A 58-year-old patient suffered from severe malabsorption due to agammaglobulinemia. Treated empirically with salicylazosulfapyridine 2--6 g/day, the subjective and objective features of malabsorption regressed. About a year after this treatment she developed a generalized weakness without renewal of the diarrhea; the diagnosis of Heinz body hemolytic anemia was established. In our patient, hemolysis began many months after the commencement of treatment and no deficiency of G6PD or other erythrocyte enzyme or pathological hemoglobin were found.
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Aseptic necrosis of bone is a known complication of corticosteroid therapy. We report a case of aseptic necrosis of the femoral head as a presenting symptom of Cushing's disease. The case demonstrates that endogenous steroids, like exogenous steroids, may bear the same relationship to the pathogenesis of aseptic necrosis of bone. It also indicates that Cushing's disease must be considered in every case of so-called idiopathic aseptic necrosis of bone.
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Postoperative prosthetic valve endocarditis due to Mycobacterium chelonei occurred in a man after replacement of the aortic valve. The organism was isolated from blood cultures and from vegetations taken postmortem from the edge of the inserted valve. This is believed to be the first documented report of a mycobacterial endocarditis.
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