[Decrease in the level and enzymatic activity of cytochrome P-450 during diethylnitrosamine metabolism in vivo and in vitro].
Diethylnitrosamine (DENA) intoxication of rats was accompanied by a reduction of cytochrome P-450 content in the liver, which correlated well with inactivation of cytochrome P-450 during metabolism of DENA in the liver microsomes.
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