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Biomedical subjects

O F GRIMES

Publications and source records attributed to O F GRIMES.

At least 37 records · Page 2Linked to original sources
PubMed1957

Pharyngoesophageal diverticula; surgical treatment.

A series of 75 cases of pharyngoesophageal diverticula observed at the University of California Hospital between 1920 and 1955 was reviewed. In 64 cases surgical repair by either a one-stage or two-stage operation was carried out. Comparison of the results by both methods appears to justify the opinion that pharyngoesophageal diverticula should be repaired in one stage in practically all instances.

Diverticulum↗
PubMed1955

Gastric polyposis.

In a series of 48 cases of gastric polyps, 40 patients had benign lesions while the polyps in the remaining eight cases were malignant. Although the symptomatology in this series was not uniform, only one patient was entirely asymptomatic. Of the eight patients with malignant lesions, three had polyps which could well be described as small, suggesting that size may not be a reliable criterion of benignity even in a single lesion. Laboratory studies indicated that anemia, achlorhydria and occult blood in the stools are frequently associated with gastric polyps. There was no apparent correlation, however, between these phenomena and the benign or malignant nature of the lesions.X-ray examination, performed in every instance, was completely negative in six cases and inconclusive in an additional five. Gastroscopy did not reveal the presence of polyps in three of 15 cases. Malignant change was detected by cytologic examination in one case in which both roentgen and gastroscopic examination were negative. The author believes that in most cases of gastric polyps operative treatment affords the greatest degree of safety. An operative procedure of considerably less extent than total gastric resection often is feasible. However, if true polyps occur where removal can be effected only by total gastric resection, the incidence of malignant change in these lesions would seem to indicate the advisability of such a procedure unless positive contraindicating conditions are present.

Achlorhydria↗
PubMed1953

Mediastinal tumors of thymic origin.

Twenty-one cases of mediastinal tumors of thymic origin are presented. Five of these were benign and 16 malignant. Surgical excision is proposed as the treatment of choice for the encapsulated benign tumors or for malignant tumors of limited extent. When surgical excision is not feasible, adequate roentgen therapy amounting to 5,000 to 6,000 r calculated tumor dose may eradicate or control the tumor. No correlation between the histological pattern of the tumor and the survival rate or radiation response could be demonstrated in this small series.

Humans↗