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Biomedical subjects

O F Dent

Publications and source records attributed to O F Dent.

64 records · Page 4Linked to original sources
PubMed1985

The relationship between different staging methods and survival in colorectal carcinoma.

A routine clinicopathologic (CP) staging system for patients who have had surgical resection for colorectal carcinoma was established at Concord Hospital in 1971. Research on this prospective series of resections has evaluated the CP staging system as a guide to prognosis. The aim of this study was to compare the CP system with the classic Dukes' staging system and its modified form introduced by Astler and Coller to determine which method provided the most accurate basis for prognosis. Life table survival analysis was used to examine the survival of 709 patients according to each staging system. Relative mortality rates for groups of patients cross-classified by each possible pair of staging systems were examined and the Cox regression model was used to determine the independent effects of staging by each system on survival. The CP system was found to have a stronger association with survival than either the classic Dukes' system or the Astler-Coller modification of the Dukes' system. The importance of supplementing data on the operative specimen with data about the spread of tumor beyond the limits of surgical resection is emphasized.

Aged↗
PubMed1984

Surgical morbidity after ileostomy in New South Wales.

While there have been several overseas studies on the quality of life after proctocolectomy, data concerning patients who have undergone ileostomy and proctocolectomy in Australia are limited. For this reason, a questionnaire was sent to all members of the New South Wales Ileostomy Association. Of the 354 who replied, the indication for ileostomy had been ulcerative colitis in 82%, Crohn's disease in 10%, familial polyposis in 4%; and 4% had undergone proctocolectomy and ileostomy for some other reason. Ages ranged from 15 to 93 years. Most subjects, of whom 51% were female, had had their ileostomy for a median of 9.4 years. Immediate postoperative complications related to the ileostomy occurred in 23% of patients, the most common causes being obstruction and sepsis. The rate of readmission to hospital for complications of ileostomy was a high 48%; 25% had further surgery. In view of these results, the need for continued efforts to develop alternative methods is emphasized.

Adolescent↗
PubMed1983

Relationship of survival to stage of the tumour and duration of symptoms in colorectal cancer.

It has been suggested that reduction of diagnostic delay in symptomatic colorectal cancer will not improve survival. Published reports show varying effects of duration of symptoms both on stage of cancer and on survival. However, tumour stage can be measured only at the end of the symptomatic period and, therefore, conclusions cannot be drawn about early diagnosis of symptomatic colorectal cancer and its effect on survival. On current evidence, early diagnosis and treatment may improve survival and should be encouraged.

Colonic Neoplasms↗
PubMed1983

A postmortem appraisal of a clinicopathologic staging system in large-bowel cancer.

The autopsy findings of 100 patients who had a resection for large-bowel cancer and who were classified by a clinicopathologic staging system were analyzed. Seventy patients had carcinoma at autopsy. The value of this method of staging was assessed by relating the stage at operation to these findings. Forty-five per cent of early stage tumors (A or B) were found to have metastases. If the detection rate of occult metastases could be improved for stage A and B tumors, this might increase the prognostic accuracy of this staging system.

Autopsy↗
PubMed1983

Participation in faecal occult blood screening for colorectal cancer.

Chemical faecal occult blood testing has been proposed as a means of screening for colorectal cancer (C.C.) in populations or in identified high-risk groups. The level of public participation is a critical factor in the effectiveness of screening programmes. This study was conducted as a methodological pretest for an intended investigation of factors influencing screening participation. Faecal occult blood screening was offered to 728 employees of a teaching hospital in Sydney, New South Wales and 41% participation was obtained. Both participants and non-participants were questioned on demographic and social background factors, on their experience of C.C. in others, and on their reasons for participating or not participating. Major reasons for participation were: a general feeling of the importance of health checks and screening tests; a belief that it is important to diagnose C.C. early; and the fact that the test was simple and easy to do. Prominent self-acknowledged reasons for non-participation were indifference, procrastination, absence of previous bowel complaints, preference for one's own doctor to do such tests and inconvenience or lack of time. Those more likely to participate were: females; those of Australian or British origin; single, separated or divorced persons; those having two or more dependents and those with personal knowledge of a C.C. patient.

Attitude to Health↗
PubMed1983

Immunodiagnosis of colorectal cancer: clinical evaluation of Tennessee antigen (Tenagen).

Blood samples from 172 consecutive patients undergoing complete colon investigations to exclude colorectal cancer (CC) were examined for levels of Tennessee antigen, i.e., Tenagen (Tg), and carcinoembryonic antigen. Patients included 48 with CC, 34 with adenomatous polyps, 14 with colitis, and 76 with no organic mucosal disease. All patients were investigated by the one clinical and histopathology department. Laboratory estimations were performed blindly. Although there were some statistically significant differences among average values, the degree of overlap among the groups of patients precludes the practical application of Tg in the diagnosis of CC.

Aged↗
PubMed1982

Clinical accuracy in the diagnosis of small polyps using the flexible fiberoptic sigmoidoscope.

Seventy-eight patients referred to a specialist clinic for investigation of large-bowel symptoms were examined with the flexible fiberoptic sigmoidoscope. One hundred twenty polyps were treated, including 84 adenomatous and 32 hyperplastic polyps. Sixty-nine per cent of polyps were situated beyond 18 cm from the anal verge. Endoscopic diagnosis was correct in 82 per cent of cases. The size of the polyp assessed endoscopically strongly influenced the clinical diagnosis but proved unreliable as a means of making an accurate diagnosis. Results indicate that whenever possible all polyps of all sizes should be removed for microscopic examination.

Adenoma↗
PubMed1982

Large bowel segment lengths and the distribution of colorectal cancer.

Data was obtained on the average length and variability of each anatomical segment and for the whole of the large bowel from 50 patients examined by air contrast barium enema X-ray examination. Results were validated by measurements of the colon and rectum removed at autopsy in ten patients. Large bowel segment measurements from barium enema X-ray examinations were shown to be a valid basis for determining the average in vivo lengths of segments. The use of descriptive terms based on the anatomical location of colorectal carcinoma should be replaced by a more exact method of defining site distribution when recording and reporting the distribution of carcinomas and operative series and for teaching purposes.

Adenoma↗