Biomedical subjects

O Dietrichson

Publications and source records attributed to O Dietrichson.

At least 55 records · Page 3Linked to original sources

PubMed1975

Acute viral hepatitis: factors possibly predicting chronic liver disease.

A number of clinical, biochemical, immunological and morphological variables were recorded at first admission of 500 consecutive patients with biopsy verified acute viral hepatitis in the period February 1969-June 1972. In February 1973, 28 of these patients had a morphologically documented chronic liver disease: 4 cirrhosis of the liver, 15 chronic aggressive hepatitis, and 9 chronic persistent hepatitis. 74 patients were followed up until morphological normalization took place. The initially recorded variables in the two groups were compared, and the following factors were significantly higher in the group with subsequent development of chronic liver disease:--frequency of drug addicts, median of the highest gammaglobulin, ANA, SMA, partial destruction of the limiting membrane, incidence of piecemeal necrosis, and pronounced plasma cell infiltration in the portal tracts. These preliminary results suggest that factors in the initial phase of acute viral hepatitis can be helpful to some extent in predicting the course and prognosis of the disease.

Acute Disease↗

PubMed1975

Acute viral hepatitis: a comparative study of clinical, biochemical, morphological and immunological features in patients with and without Australia Antigen.

500 consecutive patients with acute viral hepatitis verified by biopsy were divided into groups of 202 patients with detectable Australia (Au) antigen and 298 patients without antigenaemia at the time of admission to hospital. Comparison was made of the initially recorded clinical, biochemical, histological and serological variables in the two groups. Judged by both histological and biochemical criteria, the acute disease was more severe in the 202 patients with Au antigen than in the 298 patients without Au antigen. Evidence is presented that this difference is possibly due more to qualitative aetiological differences between the two groups than to the duration of antigenaemia or the time of hospitalization. Thus, the demonstration of Au antigenaemia provides not only epidemiological but also relevant clinical information.

Acute Disease↗

PubMed1975

Chronic persistent hepatitis. A clinical, serological, and prognostic study.

The diagnosis of chronic persistent hepatitis is based on a combination of clinical and morphological data. During a 7-year period 26 cases were diagnosed in 3 medical departments in Copenhagen. In 22 patients the disease was considered to be a sequela to acute viral hepatitis, and 12 had Australia antigen in serum. Only few patients had circulating auto-antibodies. The clinical and biochemical activity at the time of diagnosis was usually slight. A morphological and clinical follow-up study revealed that the course of the disease was generally benign. However, in 3 patients the last repeat biopsy showed progression to cirrhosis, severe portal fibrosis, and chronic aggressive hepatitis. Such exceptions may represent a sampling error in the interpretation of the first needle biopsy, or the correct diagnosis may have been chronic aggressive (active) hepatitis at a stage with slight activity. Clinical and biochemical observation is recommended in chronic persistent hepatitis, and in some patients serial needle biopsies are necessary to reveal the few exceptional cases which progress to an active chronic liver disease.

Adolescent↗

PubMed1975

Chronic active hepatitis. Aetiological considerations based on clinical and serological studies.

The diagnosis of chronic active (aggressive) hepatitis is based mainly on characteristic morphological changes. During a 7-year period, 85 cases were diagnosed in three medical departments in Copenhagen. This material is presented by clinical, biochemical, and serological variables at the time of diagnosis. None of the patients had simultaneously occurring Australia antigen and circulating autoantibodies. A comparison between two serologically homogeneous groups revealed significant differences in sex and age distribution onset of disease, and biochemical activity. The investigation suggests the existence of aetiologically different forms of chronic active hepatitis. Some cases are apparently caused by a persistent viral infection, while others may be due to a primary autoimmune mechanism. A considerable number of the patients stated that they had had prolonged intake of the potentially hepatotoxic laxative, oxyphenisatin. Nineteen patients were challenged with the drug and eight reacted with an increased biochemical activity in the liver disease. All these patients belonged to the group with circulating autoantibodies. It is possible that oxyphenisatin may be the primary cause of the chronic liver damage in some cases.

Adolescent↗

PubMed1974