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Biomedical subjects

O Dietrichson

Publications and source records attributed to O Dietrichson.

At least 19 recordsLinked to original sources
PubMed1992

[Temporal arteritis without histological changes].

A patient with severe giant cell arteritis with involvement of both eyes is presented. The symptoms were partly reversible by treatment with high doses of prednison. Three months previously (having symptoms of polymyalgia rheumatica) she had started treatment with a low dosage of prednison. Biopsies of both temporal arteries showed no signs of giant cell arteritis at that time, and the results of eye examinations were normal. The importance of follow-up on patients with symptoms of polymyalgia rheumatica, even if biopsies of the temporal arteries show no histological changes, is emphasised.

Aged↗
PubMed1979

Hepatitis B virus infections among Danish surgeons.

Acute viral hepatitis B is considered to be an occupational risk to health-care workers worldwide. At the 1977 annual meeting of the Danish Society of Surgeons, 224 participants were examined for the presence of hepatitis B surface antigen (HGsAg) and antibody to HBsAg (anti-HBs) with use of a radioimmunoassay. None of the surgeons was HBsAg-positive, but 23% had anti-HBs. The prevalence of anti-HBs was five times higher among these surgeons than that in an age-matched control population. Hepatitis acquired during occupation as a surgeon was predominantly of type B, in contrast to hepatitis acquired before entering the surgical profession. Danish surgeons must be regarded as a group at high risk of hepatitis B infection.

Adult↗
PubMed1979

Long-term follow-up of e-antigen (HBeAg)-positive acute viral hepatitis.

Eighteen consecutive patients with HBeAg in serum and histologically verified acute viral hepatitis were included in a follow-up study of the natural course of the disease. Five patients were followed up for from 2 to 6 months. Two of these healed clinically and cleared both HBeAg and HBsAg, while three were positive for HBeAg and HBsAg at the last control. Thirteen patients with a follow-up of from 27 to 102 months became HBeAg-negative during the time of observation. In all but one, progression of the liver disease stopped when HBeAg was cleared. The results further indicate a close association between the duration of HBe antigenemia and the severity of the liver disease.

Acute Disease↗
PubMed1979

Immunofluorescence studies for hepatitis A virus and hepatitis B surface and core antigen in liver biopsies from patients with acute viral hepatitis.

Immunofluorescence studies for hepatitis A virus and hepatitis B surface and core antigen were performed on liver biopsies from 48 patients with acute viral hepatitis. Hepatitis A virus was detected in 11 out of 17 patients with type A hepatitis and was not found in patients with type B or non-A non-B hepatitis. Hepatitis B surface and core antigens were detected in 2, hepatitis B core antigen alone in 1, and hepatitis B surface antigen alone in 4 out of 24 patients with type B hepatitis. Neither hepatitis B surface nor core antigen were found in patients with type A or non-A non-B hepatitis. One patient with both type A and B hepatitis were all negative for hepatitis A virus, and hepatitis B surface and core antigens. Immunofluorescence examination for hepatitis A virus in human liver biopsies appears to be a sensitive and specific technique and might be valuable in the search for possible chronic carriers of hepatitis A virus.

Adult↗
PubMed1978

Hepatitis B virus infections among Danish dentists.

Since type B hepatitis is generally regarded as an occupational risk for dentists, the participants at the 1976 annual meeting of the Danish Dental Association were examined for hepatitis B surface antigen (HBsAg) and antibody to HBsAg (anti-HBs). A total of 1,338 dentists (89% of the dentists at the meeting and 29% of all Danish dentists) were included in the study by completion of a questionnaire and by radioimmunoassay of a blood sample for HGsAg and anti-HBs. None of the dentists was HBsAg-positive, but 110 (8.2%) had anti-HBs. An increasing frequency of anti-HBs was found with increasing age, but the figures were similar to the findings in a control population. Evidence is presented that hepatitis found before admittance to or during the time at dental school was predominantly not of type B. In contrast, type B hepatitis predominated during the professional activity of the dentists. On the basis of the serological findings in 29% of all Danish dentists, it is concluded that dentists cannot be regarded as a high-risk group for hepatitis B.

Aging↗
PubMed1977

Liver-cell-membrane autoantibody specific for inflammatory liver diseases.

With an immunofluorescence technique using rabbit hepatocytes isolated by a non-enzymatic method an autoantibody directed against liver-cell-membrance was identified. Sera from 361 patients with various liver diseases and 274 patients with primary non-hepatic diseases-many associated with non-organ-specific auto-antibodies-were examined. The antibody (LMA) was found in 27 out of 72 patients with hepatitis-B-surgace antigen (HBsAg)-negative chronic active hepatitis and in 17 out of 28 patients with HBsAg-negative non-alcoholic cirrhosis. Only two patients had LMA and HBsAg, and both had chronic active hepatitis. One patient with extrhepatic disease was found to have LMA, and this patient had biochemical evidence of liver disease. Hence there is a close correlation between the presence of LMA and HBsAg-negative chronic inflammatory liver diseases and its detection may help in diagnosis.

Adult↗
PubMed1977

Acute hepatitis: a prognostic study with observation time up to 37 years. A follow-up of the Iversen/Roholm liver biopsy material.

Re-evaluation of 890 consecutive liver biopsies from 1939-59 gave the diagnosis of acute hepatitis in 147 patients. A follow-up study of these patients was performed 15-37 years after the diagnostic biopsy, based on repeated liver biopsies, biochemical liver tests, autopsy reports and death certificates. Two patients died from acute liver failure, and development of cirrhosis was documented or strongly suspected in 22 patients (15 percent). A comparison between these 24 patients with a malignant course of hepatitis and 86 patients with a well documented uncomplicated disease, revealed a significantly larger number of women, a higher age, and more cases with piece-meal necrosis, confluent necrosis and marked portal inflammation in the intitial liver biopsy in the group with the poor prognosis.

Acute Disease↗
PubMed1977

Circulating T and B lymphocytes and immunoglobulin containing cells in the liver in chronic active liver disease.

The number of circulating T and B lymphocytes was estimated in 25 patients with biopsy-verified chronic non alcoholic liver disease. Fifteen of these had circulating HBSAg and/or anti-HBSAg and 10 were without these markers of HB virus infection. In both groups of patients a significant decrease of T cells and a parallel significant increase in null cells was found, but any difference with respect to T and null cells in patients in the two groups was not observed. Liver biopsies from five of the patients with and four without HBSAg and/or anti-HBSAg were studied for the presence of immunoglobulin bearing cells. In three out of five liver biopsies from the HBSAg and/or Ab positive patients and in two out of the four liver biopsies from the HBSAg and anti-HBSAg negative patients, a heavy periportal infiltration with plasma cells was found. However, the number and classes of the immunoglobulin containing cells could not be correlated either to the histological evaluation of the stage of activity of the liver disease or to the markers for HB virus infection. The immunological findings in the two groups of patients with chronic liver disease seem to be of the same nature and are most likely a consequence of the liver disease and not the cause of it.

Adult↗
PubMed1977

The prognosis of chronic aggressive hepatitis. A clinical and morphological follow-up study.

In a follow-up study of 85 patients with chronic aggressive (active) hepatitis (CAH) repeated liver biopsies and/or autopsy liver sections were available in 74 cases. The median time of observation was 45 months. Cirrhosis was demonstrated in 38 patients, and cirrhosis was suspected in a further five cases. Fifteen patients showed convincing histological improvement; and the remaining 16 still had chronic hepatitis. Twenty-six patients died during the observation period, seven of these of liver failure after development of cirrhosis. The clinical follow-up of the 59 survivors (median observation time 69 months) showed biochemically active liver disease in 11 cases, all having cirrhosis or chronic aggressive hepatitis in the last biopsy. The clinical findings were correlated with the morphological follow-up diagnosis and the immunosuppressive treatment. Comparison of the initial histological, clinical, and serological variables was made in two well-defined follow-up groups. There were more females, and marked portal inflammation, abnormal bile duct epithelium, and circulating autoantibodies occurred more frequently in the group with later development of cirrhosis than among the patients with subsequent morphological improvement. The results thus suggest candidates for thorough follow-up and more intensive immunosupressive or other treatment.

Adolescent↗
PubMed1977

Serological evidence of hepatitis B infection in patients with chronic liver diseases: radioimmunoassay of HBsAg and anti-HBs.

The prevalence of hepatitis B surface antigen (HBsAg) and anti-HBs was determined by a sensitive double-antibody radio-immunoassay technique in a series of patients with chronic liver diseases. HBsAg was demonstrated in 37 out of 98 consecutive patients with chronic hepatitis (38%) and in 14 out of 108 patients with non-alcoholic cirrhosis (13%). HBsAg was not found in any of the patients with steatosis, alcoholic cirrhosis, or primary biliary cirrhosis. In the patients with chronic hepatitis HBsAg or anti-HBs was demonstrated in 83% of the patients below 40 years of age in contrast to 48% of the patients more than 40 years of age. It is concluded that a substantial part of the patients with chronic hepatitis has serological evidence of actual or past hepatitis B virus infection. This is in contrast to the groups of patients with other chronic liver diseases.

Alcoholism↗
PubMed1977

Humoral and cell-mediated immunity to hepatitis B virus antigens in acute and chronic liver disease.

The humoral immune response to hepatitis B virus antigens and the cell-mediated immunity to hepatitis B surface antigen (HBsAg) were investigated in 12 healthy persons and 56 patients with various liver diseases. In patients with acute viral hepatitis type B, anti-hepatitis B core antigen was present constantly in serum in all phases, and after clinical recovery simultaneously with anti-HBs. A transitory cellular immune response to HBsAg was demonstrated at the time the antigen was cleared, while a patient with persisting HBs antigenaemia and another with transient hepatitis Bc antigen showed no response during the course of the disease. Cellular immune response to HBsAg was present only infrequently in patients with chronic liver disease type B and non-B, thus suggesting that a cellular immunity to HBsAg is not a prerequisite for the development of these conditions.

Acute Disease↗
PubMed1976

Morphological changes in liver biopsies from patients with rheumatoid arthritis.

Oxphenisatin is known to induce liver damage and is suspected to cause or perpetuate chronic liver disease. In order to evaluate the hepatotoxic effect of long-term therapy with oxyphenisatin 26 consecutive patients with rheumatoid arthritis were investigated for the presence of liver disease. In all cases, liver biopsy, biochemical liver function tests and determination of Hepatitis-B antigen were performed. Ten patients showed no pathological changes in the liver biopsy and a further 2 had only non-specific changes. Seven patients had fatty liver, 5 passive congestion, one haemosiderosis and only one had cirrhosis of the liver. No correlation was found between the activity of rheumatoid arthritis, and duration of the disease, the drug therapy given, and the liver damage.

Adolescent↗