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Biomedical subjects

O C Straub

Publications and source records attributed to O C Straub.

At least 73 records · Page 4Linked to original sources
PubMed1976

Differences in the in vitro response of lymphocytes from leukotic and normal cattle to concanavalin A.

The response of cultured peripheral blood lymphocytes from cattle affected with bovine leukosis and from animals free of detectable leukosis to the nonspecific mitogen Concanavalin A ws determined by the measurement of 3H-thymidine incorporation. The stimulatory effect of the mitogen was significantly decreased in leukotic lymphocytes in comparison with normal lymphocytes. This depression was dependent on the severity of the disease. Leukotic lymphocytes showed high basal levels of spontaneous thymidine uptake possibly due to their low maturity. It is suggested that leukotic lymphocytes are not stimulated by Concanavalin A because of their B cell characteristics. A residual cell population of normal reacting lymphocytes--enriched by nylon wool column fractionation--is probably responsible for the remaining but weak in vitro reaction of leukotic lymphocytes.

Animals↗
PubMed1975

Frequency of surface immunoglobulin bearing blood lymphocytes in cattle affected with bovine leukosis.

Lymphocytes of the peripheral blood from healthy cows and animals suffering from bovine leukosis (persistent lymphocytosis or leukaemia) were examined for the presence of surface immunoglobulin determinants. Using the immunofluorescence technique an average of 18 per cent of lymphocytes from healthy and 67 per cent from leukotic cows could be recognised as positive. An increase of these positive cells, which are supposed to be B cells or of B cell origin, seems to be a characteristic finding in this disease of cattle.

Acridines↗
PubMed1975

Infectious bovine rhinotracheitis virus. History and recent developments.

The infectious bovine rhinotracheitis (IBR) virus belongs to the group of herpes viruses. It causes in cattle a severe disease predominantly in the upper respiratory tract. Morbidity rate is 100 percent, mortality - depending on hygienic and other factors - ranges from 0-15 percent. The IBR virus is serologically indistinguishable from the infect pustulat vulvovaginitis (IPV) virus which causes disorders of the genital tract in both male and female cattle. Possibly the IPV virus is the older of the two. Already in the twenties it had been isolated and described in Europe whereas IBR virus was first isolated from feedlot cattle in the USA during 1955/1956. Most likely - experiments also gave a hint - the IPV virus increased its virulence for the respiratory tract by rapid and numerous passages as this was only possible in accumulations of tremendous heads of animals. Vaccines both live attenuated and killed ones have been developed. Killed ones are always administered parenterally; the live ones are either intramuscularly injected or locally sprayed (into the nasal cavity). Immunity is developed within 3 weeks, however, if vaccinated animals are challenged, virus is again shed for a number of days. Cattle thereby do not exhibit any symptoms of disease. This is true following any kind of vaccination (live or killed). After local administration of live vaccines, however, the production of interferon by the cells of the respiratory tract is remarkable whereas parenterally administration of vaccine does not lead to that.

Administration, Intranasal↗