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Biomedical subjects

O Bouchot

Publications and source records attributed to O Bouchot.

57 records · Page 4Linked to original sources

[Primary megabladder in adults. Comments apropos of 21 cases].

Based on a review of 21 cases, clinical, urodynamic and therapeutic a of primary megalocystis in adults are discussed. This rare entity is defined as an abnormally large bladder capacity in the absence of any obstruction or neurologic lesion, and without effects on the upper urinary tract. The residue is constant whereas, paradoxically, dysuria may be absent and mictional output normal (8 of the 21 cases). Urodynamic tests distinguished two groups of patients: one in which bladder contractility was still present but decreased rapidly as a function of volume to be excreted, while flow was good; the other in which bladder contractility and flow were altered. Therapeutic possibilities are discussed as a function of results obtained. Depending upon the structural alterations of the bladder wall, medical treatment (cholinergic drugs) are usually ineffective. An interesting solution is the use of abdominal pushes in cases with hypo- or acontractile bladder. Aleatory results of surgery to reduce bladder capacity and/or reinforce bladder contraction suggest its use only as first intention surgery for bladders with retained contractile possibilities. Operations on bladder neck in women carry the risk of incontinence and should be considered only as function of results of other methods, and with the reservation that closure pressure should be at least 80 cm initially. Finally, abstention under surveillance is also an alternative in this context.

Adult↗

[Acquired phimosis, or preputial sclero-atrophic lichen in children].

From 1979 to 1988, 8 cases of balanitis xerotica obliterans were histologically demonstrated in children at Nantes University Hospital. In 6 of these 8 patients, whose average age at the time of consultation was 9.4 years, the phimosis was obviously acquired or recurrent, and the prepuce was sclerous, thick, and produced a tight distal phimosis. One child coming to consultation for relapsing urinary infections at once presented with a long, tight stenosis of the anterior ureter, associated with a dilatation of the upstream ureter and a filiform stream of urine. All the children were circumcised, and the histological study of the specimen demonstrated characteristic lesions in the superficial derma. During the same operation, meatostomy was performed in two children presenting with meatal stenosis. Six of 8 children were followed up with an average time lapse of 6 months: one of them presented with an involvement of the glans penis and a moderate meatal stenosis, which disappeared spontaneously. No improvement occurred for the child presenting with an extensive stenosis of the anterior ureter, in spite of the local instillation of androgens then of corticoids, but his left kidney was dilated on sonograms. Balanitis xerotica obliterans in children is often not recognized and regarded as a common phimosis; it can be suspected because of the clinical features of the phimosis. The condition must be confirmed by the histological study of a circumcision specimen, then followed up regularly to prevent any risk of involvement of the glans, of the ureteral meatus or of the anterior ureter.

Adolescent↗

[The prevention of the recurrence of stage pTa bladder tumors using intravesical instillation of BCG].

45 patients were included in a retrospective study designed to assess the long-term efficacy and tolerance of immunotherapy by intravesical BCG instillation in the treatment of stage pTa bladder tumours (mean follow-up 52.7 months, range: 12-87 months). 41 patients (91% responded to immunotherapy: 24 (53%) did not develop anu recurrences with a mean follow-up of 49.4 months (range: 19-87 months) and 17 (37.7%) were improved by treatment as the interval between recurrences was significantly increased. 4 patients (8.8%) failed to respond to BCG therapy with progression to stage pTa G3 vesical papillomatosis in one patient. The local tolerance was poor for twelve patients (26.6%), requiring discontinuation or spacing of the instillations. Other complications such as prostatitis and intense fever were observed. Three patients had persistent disturbances of micturition following treatment in the form of urinary frequency due to the decreased bladder volume. Neither the grade, nor the frequency of recurrences prior to treatment, nor the solitary or multifocal nature, nor the site of the initial tumour appeared to influence the response to BCG therapy and did not constitute independent individual prognostic indicators.

Administration, Intravesical↗