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Biomedical subjects

O Betti

Publications and source records attributed to O Betti.

11 recordsLinked to original sources
PubMed1988

[Stereotaxic diagnosis and treatment of colloid cysts of the 3d ventricle. Apropos of 7 cases].

The clinical and anatomical results of the treatment of 7 colloid cysts of third ventricle by stereotaxic aspiration are reported. A history of increased intracranial pressure was reported in all patients (4 females aged of 12, 16, 28, 38 years; 3 males aged of 36, 54, 59 years). A ventricular shunting device has been inserted in 4 patients. Pre-operative clinical findings were: signs of increased intracranial pressure (1 case), isolated memory disturbances (3 cases); motor weakness, memory disturbances and psychomotor slowness (2 cases); 1 of the 2 last cases had also thymic disturbances. Clinical examination was normal in 1 patient. CT-Scan revealed 5 hyperdense lesions, 3 with slight enhancement; 1 hypodensity encircled by an hyperdense ring without enhancement, 1 not enhancing isohypodensity. 6 colloid cysts were between the Foramens of Monro, 1 in the posterior third ventricle. Cyst volume ranged from 1.8 to 6.3 cc. (m: 3.4). Biventricular hydrocephalus was present in all but 1 patient. Stereotaxic aspiration of the cyst performed according to Talairach's system resulted in a release of C.S.F. circulation in all cases. 3 colloid cysts were aspirated completely, 4 were reduced to 3%, 11%, 12%, 33% of the initial volume. Post-operatively 2 patients presented with a transient meningeal reaction, 1 with a transient "myoclonic" syndrome. In 1 "completely aspirated" case a control CT-Scan showed, 5 years later, a small hyperdensity corresponding to 4% of the initial cyst volume. All patients lead a normal and useful life (Follow-up: 8-78 months, m: 45). Neurological examination is normal in 6 cases and shows a pre-existent facial asymmetry in 1. Ours results suggest that stereotaxic investigation should be the first safe procedure in order to achieve both diagnosis and treatment of colloid cysts of third ventricle.

Adolescent↗
PubMed1987

[Complementarity of x-ray computed tomography of staged stereotaxic biopsies and of stereo-electroencephalography in the spatial definition of intracranial lesions].

This study concerns 180 patients (132 M; 48 F) (age: 2 to 69 years; m: 33 years) who underwent stereotactic procedures according to the methodology of Talairach and Szikla. Such procedures (stereotactic and stereoscopic angiography in all cases, and ventriculography in 81%) should permit a correct spatial definition of intracranial lesions. The informations provided by the angiography (normal in 7%) and by the ventriculography (normal in 11%) are complementary to those yielded by the TDM and permit an easier and safe stereotactic approach to the lesions. In 43% of patients the lesions were deep-seated (basal ganglia: 24; sellar region: 19; thalamo-peduncular: 13; brain stem: 6, etc.). The histological examination showed: low-grade gliomas in 43%; glioblastomas in 21%; non tumoral lesions in 17%. A precise diagnosis couldn't be obtained in 3.8%. The data provided by the stereo-EEG (in 11 patients suffering also of severe drug-resistant partial epilepsy) did not permit, alone, an histological diagnosis, excepted when electrodes explored a solid tumor. Two patients had a neurological impairment, and two died (one for extracerebral reasons). The authors consider that the TDM data and the informations given by the stereotactic procedures are complementary for obtaining valuable informations on the spatial organization of intracranial lesions and choosing the best treatment.

Adolescent↗
PubMed1987

[Value and technic of translating the data from x-ray computed tomography into the stereotaxic coordinates of the Talairach system].

The neuroradiological stereotactic examinations provide indispensable information to localize many intracranial lesions: the data obtained by the CT-Scan are complementary of the stereotactic ones. The transfer of the routine CT-Scan transverse axial slices into the Talairach stereotactic system needs a precise definition of the inclination of the plan of the slices and a correct evaluation of the mean magnification factor. The inclination of the slices is appreciated using the bony, vascular and ventricular landmarks clearly identified on the CT-Scan and stereoscopic stereotactic images. We compared the spatial "reconstructed" CT-Scan data with the histopathological findings obtained by serial stereotactic biopsies in 48 tumor patients. The error varied from 1.5 to 4.6% (m: 2.7 +/- 1.2) on the sagittal plane; from 1.3 to 10% (m: 5.8 +/- 3.4) on the transversal plane; from 2.5 to 4.3% (m: 3.5 +/- 0.7) on the axial plane. The mean global error was 3.7% +/- 2.3. The CT-Scan directly performed under stereotactic conditions (acrylic frame) seems to be the more useful procedure. Nevertheless considering the good precision obtained with our methodology applied to the Talairach's system, we consider it suitable when: a) the gantry of the CT-Scan apparatus is too narrow for the acrylic frame; b) the exploitation of previous CT-Scan examinations is necessary; c) patient refuses the discomfort of the acrylic frame.

Brain Diseases↗
PubMed1987

Stereotactic aspiration of colloid cysts of the third ventricle. Preliminary report.

From January, 1979, to July, 1986, 10 patients (6 females, 4 males; 12-59 years, mean 37) with colloid cysts of the third ventricle were treated by stereotactic aspiration (Talairach's method). Five cysts have been completely aspirated. The mean residual volume of the other 5 was 19% of the initial volume. Clinical symptoms completely cleared in all but one patient. The advantages of the procedure are discussed.

Adolescent↗
PubMed1985

[Stereotaxic treatment of expanding cysts in craniopharyngiomas by endocavitary beta-irradiation (Re-186; Au-198; Y-90)].

The authors report the results of 17 intracystic injection of colloidal 186 rhenium, 2 colloidal 198 gold, and 1 colloidal 90 yttrium for endocavitary treatment of 18 cystic craniopharyngiomas (16 pts during a period ranging from January 1975 till July 1982. Follow-up studies ranging from 12 to 72 months (m: 36 m) revealed that all craniopharyngiomas cysts were effectively treated with cessation of fluid formation, progressive shrinkage of the formerly expansive cysts, and finally cyst obliteration in 75% of the cases. No early or late side-effects were observed during the entire observation period. Late reexpansion of one craniopharyngioma cyst, observed at 11 months, was successfully treated by a second injection. Leakage of colloid isotope into the CSF spaces during the "test" or "therapeutic" injections occurred in 18% of the global number of injections, however no clinical complications were observed. On the basis of a clinical dosimetric study a 30 000 rads wall-dose, not exceeding 40 000 rads is actually considered as the safer dose for endocavitary treatment of craniopharyngioma.

Adolescent↗
PubMed1983

[Multiple-beam stereotaxic irradiation].

The "Talairach" stereotactic multibeam irradiation system developed by the authors allows to irradiate selectively small intracranial or intraorbital lesions localized in the Talairach stereotactic system. The centre of the target volume is placed in the isocentre of rotation of a linear accelerator (160 degrees), a special head fixation allows for a stepwise rotation of the head (145 degrees) around the centre of the lesion. Special collimators adapt the width of the high energy photon beam to the dimensions of the target (some millimeters to 3 cm), creating a high dose radiation field limited to the lesion (deep AVM, pituitary adenomas, small gliomas in critical areas etc.).

Humans↗
PubMed1981

[Current experience of stereotaxic irradiations in the treatment of hemispheric gliomas (author's transl)].

Authors present a short review of the techniques and results of the stereotactic focal irradiations (S.I.) used at present in France for the treatment of small "active" gliomas localized in high risk areas (functional and vital) of the brain. These techniques include the temporary interstitial implantation of 192Ir wires, possibly associated with external irradiation and the treatment of active glioma cysts by intracystic injection of colloidal beta emitters such as 90Y and 186Re. The risk of immediate (surgical) and late (radiation) functional loss is low and the overall results at 3 years are satisfactory in particular with small well delimited astrocytomas. Such treatments can be associated to surgical reduction of the tumor volume or to other forms of irradiation according to the data of stereotactic localization studies including biopsy.

Adolescent↗
PubMed1972

Stereotactic hypothalamotomy for behaviour disorders.

Posterior hypothalamotomy is a relatively simple stereotactic procedure. The radiological determination of the target and its physiological corroboration by electrical stimulation are accurate. The lesions have always been made in the site of maximum sympathetic response. In this respect, the cardiovascular changes (hypertension and tachycardia), which are always elicited from a more restricted area, are of particular importance. Depth recordings, however, have been less useful. Undesirable side-effects, if present, were mild and transitory. There was no postoperative intelligence deficit, at least with the standard tests.

Adolescent↗
PubMedDate not supplied

Circadian patterns of growth hormone, prolactin and corticotrophin secretion in hypothalamic and extra-hypothalamic lesions localized by stereotactic neuro-radiology in humans.

The integrity of mediobasal hypothalamus for the maintenance of normal circadian rhythms has been clearly established in the animal. Using precise stereotactic neuroradiologic localisations of various brain tumors, the authors demonstrate that in human, cortical lesions induce no significant modifications of the circadian variation of GH, prolactin or ACTH. In contrast subcortical lesions displacing the 3rd ventricle result in an inhibiton of the nocturnal rise in GH and prolactin, whereas the circadian rhythm of ACTH remains normal.

Adrenocorticotropic Hormone↗