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Biomedical subjects

O Axelsson

Publications and source records attributed to O Axelsson.

85 records · Page 5Linked to original sources
PubMed1981

Endometrial effect of vaginal estriol treatment. A scanning electron microscopic study of the luminal surface.

Estriol, 0.5 mg, was administered intravaginally as ovula once a day for 16 days to 5 menopausal women. Endometrial biopsies were taken before and after the last day of treatment. Before the treatment scanning electron microscopy showed a typical menopausal uterine surface with sparsely occurring ciliated cells among the non-ciliated ones. The non-ciliated cells possessed a small number of short microvilli. After estriol treatment the ciliated cells occurred more frequently. The cells possessed more numerous and longer microvilli and several non-ciliated cells showed apical protrusions. These changes are considered to be signs of an estrogenic influence. It is concluded that the estriol release from the vaginal ovula is sufficient to induce an estrogenic response in the surface of the uterine epithelium.

Aged↗
PubMed1981

Results of cervical cerclage operations in pregnant women during a five-year period.

During the five-year period from 1974 to 1978, 102 pregnancies (0.67% of all deliveries during this period) were treated with cerclage operations. The 16th week of pregnancy was the most common time for operation. In the majority of the cases the indication for surgery was strictly prophylactic; the women had a history of one or more second or early third trimester foetal losses, but there was no dilatation or effacement of the cervix at the time of surgery. No abortions were caused by the surgery. The most serious complication observed was a vesicovaginal fistula. Prior to their first cerclage operation the women investigated had an infant survival rate of 42% of their pregnancies. In the treated pregnancies the corresponding figure was 91%. It is concluded that cerclage operations performed mainly on the basis of prophylactic indications are justified since severe complications are rare and cerclage may be a useful tool to prolong pregnancies and thus improve the prognosis for infants of women with a history of second trimester foetal losses.

Abortion, Habitual↗
PubMed1980

Incorrect diagnosis of placental insufficiency in a patient with pre-eclampsia.

A case of pre-eclampsia is described where suspicion of placental insufficiency arose due to low estriol levels and a positive oxytocin challenge test (OCT). The cause, however, of these findings was later proven to be strictly fetal. It is concluded that low estriol levels and a positive OCT may be caused by a decreased placental capacity but specific tests of placental function, as for instance estimations of HPL in plasma and/or a DHAS-test, should be used to verify or rule out a suspicion of placental insufficiency.

Adult↗
PubMed1978

A radioimmunoassay of oestrone in plasma. Plasma levels of oestrone and oestradiol in oophorectomized Rhesus monkeys during treatment with subcutaneous implants containing oestrone.

A highly specific antiserum to oestrone was used to develop a sensitive radioimmunoassay. Plasma was generally analysed without prior separation of the oestrogens. A small amount of plasma (0.1-0.2 ml) was extracted once with diethyl ether. The above and previously described radioimmunoassays were used to estimate plasma levels of oestrogens in oophorectomized monkeys treated with subcutaneous oestrone implants. Three monkeys received a rod containing 40 mg of oestrone. The rods were kept in place for about one year. The release rates from the rods were calculated. The oestrone plasma levels were initially high (370-500 pg/ml). In about 3 months they had fallen to a level of 50-100 pg/ml which was maintained till the removal of the rods. A rise in the oestradiol plasma levels was also observed. It is concluded that rods are suitable for administration of oestrone.

Animals↗
PubMed1978

Plasma levels of non-conjugated oestrone in high risk pregnancies.

Plasma levels of non-conjugated oestrone were measured with a radio-immunological method in women with complicated pregnancies during the last trimester. A comparison was performed between values of normal pregnancies from a previous report (3) and those of pathological pregnancies. Women with severe pre-eclampsia were found to have low values and to some extent the oestrone level could predict fetal outcome. In pregnant patients with long-standing diabetes mellitus the plasma levels of oestrone seemed to be higher than those of uncomplicated pregnancy. In women with pregnancies complicated by Rh-isoimmunization, oestrone plasma levels were similar to those found in normal pregnancies.

Antibody Formation↗
PubMed1977

A radioimmunological method for oestrone. Plasma levels of non-conjugated oestrone during uncomplicated pregnancy.

A specific antiserum to oestrone has been used to develop a radioimmunoassay. No chromatographic separation step was included. A small amount of plasma (0.01--0.15 ml) was extracted once with diethyl ehter. The method was used to estimate plasma levels of non-conjugated oestrone in women during uncomplicated late pregnancy. The oestrone plasma concentrations showed a gradual increase from a mean of 4 ng/ml in the 22nd week to 11 ng/ml in the 41st week. Great individual variations were found. No systematic changes of unconjugated oestrone plasma concentrations were noticed during a 24-hour period in late pregnancy. Short term studies revealed that large and rapid fluctuations may appear in the levels of unconjugated oestrone during pregnancy.

Estrone↗
PubMedDate not supplied

Fetal tachycardia: intrauterine and postnatal course.

Eighteen consecutive cases of fetal tachycardia referred to the department of Pediatric Cardiology, Uppsala University, were studied retrospectively. All cases were detected at a routine visit at an antenatal clinic. None of the cases had a structural heart disease. Fetal supraventricular tachycardia was found in 8 cases and atrial flutter in 10 cases. In 7 cases, hydrops and heart failure were diagnosed. Antenatal treatment with digoxin, alone or in combination with other antiarrhythmic drugs, was needed in 15 cases. In 10 cases an obvious effect of the therapy was observed. No intrauterine deaths occurred. One infant died postnatally. At birth, 4 infants were in need of neonatal intensive care when delivered. Antiarrhythmic treatment was started in 13 cases postnatally. Late relapse of tachycardia was reported in 3 children. In 1 of these cases the prenatal tachycardia had resolved spontaneously and the infant was not treated antenatally nor during the neonatal period. Although fetal tachycardia is a serious condition, antenatal treatment in combination with careful monitoring and induction of delivery in cases with deteriorating fetal condition result in a satisfactory outcome for the majority of infants. However, there is a risk of late recurrence.

Adult↗