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Biomedical subjects

O Araya

Publications and source records attributed to O Araya.

7 recordsLinked to original sources

Chronic hepato-toxicity of Senecio erraticus in calves from two 50-day feeding periods in consecutive years.

One-year-old male Holstein Fresian calves were fed low doses of Senecio erraticus during two 50-d periods in consecutive years to determine its chronic effect on the liver. Toxic liver effects were determined by monitoring serum levels of hepatic enzymes, bromosulphthalein retention (BSP), and histopathological changes in the liver at times before, during and after Senecio ingestion. A gradual increase in BSP retention was observed at days 60 and 90 during the first feeding period. Histological studies of the liver showed hepatocellular megalocytosis and karyomegaly, and hypertrophy of Kupffer cells in both groups. Periportal fibrosis, bile duct proliferation and the presence of periportal hyperchromatic and hypertrophic hepatocytes was seen after the second feeding period.

Age Factors

Serum changes and histologic liver lesions due to experimental ingestion of ragwort (Senecio erraticus) in sheep.

Eight 1-year-old Romney-Marsh female sheep were used to test the effect of Senecio erraticus (ragwort). Animals were fed for 60 days on a standard diet incorporating 20% dried ground ragwort. Morphology of the livers was studied by serial biopsy and function by changes in plasma bilirubin concentration, the half-life of bromosulphthalein (BSP), and by the activity of glutamate dehydrogenasa (GD) in plasma during and after Senecio ingestion. All sheep had an increase in bilirubin concentration and GD activity in their plasma and in BSP half-life. These values returned to normal 30 days after ragwort ingestion ceased. Histological studies showed Kupffer cell hypertrophy, fatty degeneration and megalocytosis. These lesions almost disappeared 60 days after stopping Senecio ingestion.

Animals

Ford EJ.

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Aminopyrine N-Demethylase