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Biomedical subjects

O Adam

Publications and source records attributed to O Adam.

67 records · Page 4Linked to original sources
PubMed1980

Platelet fatty acids and prostaglandin turnover during defined linoleic acid intake with formula diets.

Platelet fatty acids, platelet aggregation and excretion of main urinary metabolites of prostaglandins were investigated in six healthy females under the influence of liquid formula diets providing a linoleic acid supply of 0 g or 50 g per day for three weeks each. With high intake we found an increase of linoleic acid in platelet lipids from 4.5 to 8.3% on average, while dihomogamma-linolenic acid (20:3 w 6) decreased, and arachidonic acid content of platelet lipids was not changed. ADP induced platelet aggregations decreased under high linoleic acid intake to 84 +/- 6 (mean +/- S.D.) percent of control values. This occurred despite enhanced prostaglandin turnover, measured by determination of main urinary prostaglandin metabolites. It seems, therefore, that the influence of high linoleic acid intake on arachidonic acid metabolism is different in platelets and other body tissue.

Adult↗
PubMed1979

The influence of linoleic acid intake on the excretion of urinary prostaglandin metabolites.

The influence of linoleic acid intake on human prostaglandin formation was investigated by gas chromatographic determination of dimethyl tetranorprostanedioate, a derivative of the major urinary end products of prostaglandin metabolism. Six healthy female volunteers were put on liquid formula diets. Each person had a linoleic acid supply of 0, 10, and 50 g per day for periods of two weeks. At the end of these periods the corresponding average amounts of tetranorprostanedioic acid in urine were 92, 175, and 326 microgram per day.

Adult↗
PubMed1979

[Dose-effects studies with bezafibrate in patients with hypercholesterolemia and hypertriglyceridemia (author's transl)].

The dose-effect relationship of bezafibrate, a new clofibrate derivative, was investigated in 24 outpatients with a primary hyperlipidemia and a Type lla lipoprotein pattern. The patients were divided into two groups at random and in each case received 3 X 50, 3 X 100, 3 X 150 and 3 X 200 mg bezafibrate daily in increasing or falling dosage for four weeks. For rising doses a statistically significant dose-effect relationship could be demonstrated for cholesterol and triglycerides. This was only true for cholesterol with falling doses while triglycerides remained at a low level. The optimal dose was found to be 600 mg bezafibrate daily. The substance was well tolerated, and the usual laboratory parameters remained within the normal range in all patients.

Cholesterol↗
PubMed1979

[The effect of formula diets with a modified fat content on human plasma phosphatide fractions].

Variation of human plasma phospholipids by formula diets with different composition of fat are caused by changes of the lecithin fraction, which amounts to 70 to 80% of total phospholipids. The changes of lysolecithin correspond to that of lecithin. The absolute amounts of sphingomyelin are unchanged by the different formula diets, while the relative amounts are negatively correlated to the lecithin fraction.

Dietary Fats↗
PubMed1975

[Investigations on mycoplasma attacks in patients with chronic bronchitis (author's transl)].

In 50 patients with chronic bronchitis, and additional attack by mycoplasma was found in at least 4 cases. This percentage corresponds approximately to the statements in the literature. In patients with mycoplasma in the sputum, radiologically signs of a bronchitis and peribronchitis were found which, for the short duration of the symptoms are unusual for a chronic bronchitis. Purulent sputum was only observed after several days in the many relapses which ran a course similar to a virus infection.

Adult↗
PubMed1975

[Mycoplasma in inflammatory diseases of the resporatory tract (author's transl)].

Methods for the serological and bacteriological investigation of mycoplasma and the clinical symptoms in infections with identified mycoplasma are described. The significance of mycoplasma in inflammatory diseases of the respiratory tract is a matter for discussion according to present knowledge. The pathogenicity of Mycoplasma pneumoniae in atypical pneumonias can be considered confirmed according to the availabile literature; its importance for other inflammatory diseases of the respiratory tract, particularly for chronic bronchitis, is not yet sufficiently clear. Further specific studies are necessary with a selected, reliable series of patients under carefully defined precautions.

Acute Disease↗
PubMedDate not supplied

Computer-assisted ABR interpretation using the automatic construction of the latency-intensity curve.

In this paper, we present a new computerised technique for the automatic construction of the latency intensity curve (LI curve). We take a pattern recognition approach determined by a priori information. We use knowledge gained from the audiogram and from physiological considerations. Therefore, we consider all recordings at different intensities as well as results from the extraction of a single auditory brainstem response (ABR) at a given stimulus intensity. We tested our method successfully: it allows us to prevent misrecognition errors in response detection or in latency measurements. Automatic recognition of the waves and recognition by the ear, nose and throat (ENT) specialist coincided in at least 90 per cent of cases. For wave V, the average deviation between the response thresholds given by our automatic recognition algorithm and those given by the ENT specialist was 5 dB, and the average deviation of the latencies was 0.05 ms.

Auditory Threshold↗
PubMedDate not supplied

[Pasteurella multocida as a cause of septic arthritis in the elderly].

Pasteurella multocida as cause of septic arthritis was only reported in patients with underlying joint damage or altered systemic host defense. We report a case of septic arthritis of the shoulder in a 92-year-old, previously healthy woman. It is concluded that Pasteurella multocida can cause septic arthritis in aged persons without precedent joint damage.

Aged↗
PubMedDate not supplied

[Nutrition as adjuvant therapy in chronic polyarthritis].

In the literature many casual observations report an arthritogenic effect of individual nutrients. The discovery of eicosanoids derived from arachidonic acid (AA) as most relevant mediators of joint inflammation allowed to elaborate the basis for a dietary therapy of rheumatoid arthritis. With an average intake of 18 g/d linoleic acid in western societies, linoleic acid is not converted to AA, and plasma levels of AA depend on its dietary intake with meat or meat products. The amount of AA ingested with the diet correlates with the formation of proinflammatory eicosanoids. Additionally, AA levels can be lowered by the ingestion of fish oil fatty acids. In our experiment, we aimed to combine the effect of low AA intake with the known anti-inflammatory effect of fish oil fatty acids. Our results demonstrate that vegetarians have lower AA percentages in erythrocyte lipids compared to the control group. The lower AA levels in plasma lipids coincided with higher percentages of fish oil fatty acids after supplementation, resulting in lower formation of mediators of inflammation. Moreover, the vegetarian group experienced a more pronounced decrease of AA in erythrocyte lipids after supplementation with fish oil fatty acids. These effects are supposed to contribute to the more favorable clinical course and laboratory findings in patients with rheumatoid arthritis on a vegetarian diet.

Arachidonic Acid↗