[The immunogenic properties of liposomal preparations formed from a base of phospholipid antigenic complexes].
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Biomedical subjects
Publications and source records attributed to O A Timasheva.
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In this article materials on obtaining rickettsial liposomal preparations on the basis of R.prowazekii phospholipid antigen and chemical typhus vaccine are presented. Electron microscopic studies revealed the formation of liposomes in this system. Liposomal preparations were not hemotoxic and produced no toxic action in experiments on guinea pigs and white mice. Phospholipid antigens incorporated into liposomal preparations were found to produce a potentiating effect on the immunogenic properties of chemical typhus vaccine. The adjuvant properties of rickettsial phospholipids incorporated into liposomes on the basis chemical typhus vaccine were registered.
In this article the problems of immunodiagnostics of generalized and local chlamydial infections are discussed. Extensive material is used for the substantiation of the expediency of using serological methods for diagnosing zoonotic and anthroponotic chlamydial infections. A rational scheme of using the passive hemagglutination (PHA) test and the complement fixation test for the detection of generalized chlamydial infections, as well as the PHA test and the indirect immunofluorescence test for diagnosing urogenital chlamydial infections.