[The basic gastroenterological diet].
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Biomedical subjects
Publications and source records attributed to O A Plotnikova.
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A study was made of the effect of wheat bran contained by the antisclerotic diet on lipid metabolism in patients with chronic coronary heart disease. Eighty-two patients (males) aged 36-59 years with a history of myocardial infarction of 1- to 15 year-standing were entered into the study. It was ascertained that inclusion into the antisclerotic diet of wheat bran in an amount of 70-80 g does not exert any hypolipidemic action. No elevation of the serum alpha-cholesterol content was noticed either. The augmentation of the cholic acid concentration together with a reduction in the cholesterol content in the hepatic bile attests to its reduced lithogenicity.
The influence of the diet containing 10 g of citrus pectin, made by "Copenhagen-Pectin-Fabric", on some parameters of lipid and carbohydrate metabolism was studied in 33 coronary heart disease male patients, aged from 29 to 40 years, who had survived documented myocardial infarction. The results of the investigation have evidenced that increased pectin content in the diet promotes the reduction of the total cholesterol and triglyceride levels in the blood serum, the rise of tolerance to carbohydrates and produces no appreciable effect on the lithogenic potential of bile in the coronary patients.
The dynamics of blood lipid values, activity of the kallikrein-kinin system and immunologic responsiveness were studied in coronary patients (males aged 43-56 years) who had survived myocardial infarction, during dietotherapy with rations in which 2/3, 1/3 and 1/2 protein were sequentially substituted for soybean protein. The hypocholesterolemic action of soybean protein correlated with its content in the ration, the kallikrein and prekallikrein levels in the blood serum rose simultaneously with a tendency to decrease in the tryptic and to increase in the inhibitory activity of the blood, positive shifts in the cellular immunity were recorded in the patients followed up during dietotherapy.
Combined product containing soybean isolate 500E (produced by "Ralston Purine Company", USA) were clinically used in 16 patients with hyperlipidemia, type II. The results obtained evidenced a high assimilability (95.5-95.9%) and pronounced hupocholesterolemic effect of the soybean isolate when it was used as a substitute for 2/3 or 1/2 protein volume in the ration.
The effects of two isocaloric antiatherosclerotic diets (containing 120 g protein) differing in the amino acid composition of protein sources introduced were studied and compared in patients with coronary heart disease. Conventional protein sources were used in the first diet, whereas in the second diet, 15% of protein (by weight) was replaced by soybean protein isolate. A study was also made of the effect of dietetic management on lipid metabolism in blood serum. Hemocoagulation, capillary permeability, the kallikrein-kinin system, and immune responsiveness. An increase in the hypolipidemic effect of the diet was noted together with a decrease in the activity of the kallikrein-kinin system, capillary permeability, and body autosensitization upon introduction into the diet of soybean protein isolate. The increase of the protein quota as well as that attained by means of introducing in the diet of soybean protein isolate reduces the therapeutic effect of the diet on hemostasis.