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Biomedical subjects

Nisha Patel

Publications and source records attributed to Nisha Patel.

5 recordsLinked to original sources
PubMed2006

Acquired ichthyosis.

Acquired ichthyosis (AI) is a nonhereditary cutaneous disorder characterized by dry, rough skin with prominent scaling that involves significant portions of the body. It has been associated with malignancies; autoimmune/inflammatory, metabolic, endocrine, and infectious diseases; and medication use. Most microscopic studies of AI exhibit hyperkeratosis with a reduced or absent granular layer. Because AI has been linked to a variety of conditions, the workup of a patient presenting with this finding can be complex. We present an update on AI to provide clinicians with direction regarding the assessment and treatment of patients presenting with AI. An algorithm for the evaluation of patients presenting with AI is provided.

Algorithms↗
PubMed2006

Pharmacological profile of antipsychotics at monoamine receptors: atypicality beyond 5-HT2A receptor blockade.

Antipsychotic drugs (APD) are widely prescribed for the treatment of schizophrenia. The APD are differentiated into typical and atypical based on the lower incidence of extra-pyramidal side-effects associated with the newer atypical APD. It was suggested that atypicality may arise from an interaction with the 5-hydroxytryptamine (5-HT)(2) receptor and specifically on the 5-HT(2):dopamine D(2) affinity ratio. It is now realised that multiple subtypes of these receptors exist and that in addition, atypical APD interact with many monoamine receptors. The aim of the present study was to characterise the interaction of APD with a variety of monoamine receptors in terms of both affinity and efficacy. The data produced has highlighted that the atypical profile of APD such as olanzapine and clozapine may reflect antagonism of the 5-HT(2A) and 5-HT(2C) receptors, whilst that of, ziprasidone and quetiapine may reflect partial agonist activity at the 5-HT(1A) receptor, and that of aripiprazole may reflect partial agonist activity at the 5-HT(1A) receptor as well as is its claimed partial agonist activity at the dopamine D(2) receptor.

Animals↗
PubMed2003

Vertical vergence adaptation does improve with practice.

PURPOSE: To investigate the effect of repeated testing on adaptation to a 2 Delta vertical prism in subjects with normal binocular single vision. METHODS: Subjects were required to have good visual acuity and normal binocular single vision. The residual deviation was measured after a 1-min period of adaptation to a 2 Delta vertical prism using a modified Maddox Rod technique. This measurement was repeated 10 times, with a 5-min rest period between each trial. RESULTS: For eight young adult subjects, the mean residual deviation at 1 min reduced with consecutive trials, and this effect was statistically significant (p < 0.0001). No significant correlation was present between the amplitude of vertical vergence and the increase in adaptation with repeated demand. CONCLUSIONS: A practice effect for vertical vergence adaptation appears to be present in young adult subjects with normal binocular single vision.

Adaptation, Ocular↗