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Biomedical subjects

Nick Polydorides

Publications and source records attributed to Nick Polydorides.

2 recordsLinked to original sources

Improving the forward solver for the complete electrode model in EIT using algebraic multigrid.

Image reconstruction in electrical impedance tomography is an ill-posed nonlinear inverse problem. Linearization techniques are widely used and require the repeated solution of a linear forward problem. To account correctly for the presence of electrodes and contact impedances, the so-called complete electrode model is applied. Implementing a standard finite element method for this particular forward problem yields a linear system that is symmetric and positive definite and solvable via the conjugate gradient method. However, preconditioners are essential for efficient convergence. Preconditioners based on incomplete factorization methods are commonly used but their performance depends on user-tuned parameters. To avoid this deficiency, we apply black-box algebraic multigrid, using standard commercial and freely available software. The suggested solution scheme dramatically reduces the time cost of solving the forward problem. Numerical results are presented using an anatomically detailed model of the human head.

Algorithms↗

Krylov subspace iterative techniques: on the detection of brain activity with electrical impedance tomography.

In this paper, we review some numerical techniques based on the linear Krylov subspace iteration that can be used for the efficient calculation of the forward and the inverse electrical impedance tomography problems. Exploring their computational advantages in solving large-scale systems of equations, we specifically address their implementation in reconstructing localized impedance changes occurring within the human brain. If the conductivity of the head tissues is assumed to be real, the pre-conditioned conjugate gradients (PCGs) algorithm can be used to calculate efficiently the approximate forward solution to a given error tolerance. The performance and the regularizing properties of the PCG iteration for solving ill-conditioned systems of equations (PCGNs) is then explored, and a suitable preconditioning matrix is suggested in order to enhance its convergence rate. For image reconstruction, the nonlinear inverse problem is considered. Based on the Gauss-Newton method for solving nonlinear problems we have developed two algorithms that implement the PCGN iteration to calculate the linear step solution. Using an anatomically detailed model of the human head and a specific scalp electrode arrangement, images of a simulated impedance change inside brain's white matter have been reconstructed.

Algorithms↗