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Biomedical subjects

Nandkishor S Kabra

Publications and source records attributed to Nandkishor S Kabra.

6 recordsLinked to original sources
PubMed2004

Nitric oxide in preterm infant with pulmonary hypoplasia.

Premature infants with hypoplastic lungs may have elevated pulmonary vascular resistance with right to left shunt across ductus arteriosus and/or foramen ovale. Inhaled nitric oxide (NO) being selective pulmonary vasodilator without significant effects on systemic circulation can potentially reverse this shunt. The authors herewith report a case of a premature infant with severe hypoxemic respiratory failure after preterm premature prolonged rupture of membranes leading to oligohydramnios and pulmonary hypoplasia that was treated successfully with NO and describe the neurodevelopmental outcome at 1 year of age.

Administration, Inhalation↗
PubMed2004

Role of carnitine supplementation in apnea of prematurity: a systematic review.

OBJECTIVE: To determine the role of carnitine supplementation in premature infants on apnea of prematurity, length of ventilation and duration of hospital stay. METHODS: Two reviewers independently conducted a literature search for relevant studies. No language restrictions were applied. Decisions to include studies for the review, and methodological quality of the included studies were assessed in duplicate based on predetermined criteria. RESULTS: Three studies met the selection criteria (reproducibility-kappa 0.76+/-SE 0.122). One study was later excluded. Both included studies were randomized double-blind placebo control prevention trials among babies <1500 g of weight. There was no difference among the groups for outcomes of bedside nurse recorded frequency of apnea episodes, continuous objective recording of apnea, length of ventilation (WMD -3.24 days, 95% CI -8.39, 1.92) or length of hospital stay (WMD -5.4 days, 95% CI -15.53, 4.72). CONCLUSION: Present evidence does not support the regular use of carnitine for the prevention of apnea of prematurity.

Apnea↗