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Nancy R Gough

Publications and source records attributed to Nancy R Gough.

At least 19 recordsLinked to original sources
PubMed2007

2006: signaling breakthroughs of the year.

With nominations from leading scientists studying cell signaling, the STKE editors compile a list of the year's most important advances. Signaling breakthroughs included molecules and processes both outside cells and inside cells, from channels in the membrane to chromatin in the nucleus. The nominated research ranged from structural and functional revelations to approaches for the global analysis of signaling pathways. Receptors were highlighted with unexpected proteins functioning as receptors, as well as surprising functions for known receptors. This year also brought new insights into the impact of cell signaling on human physiology and disease.

Animals↗
PubMed2006

Signal reception and transmission.

From plants to yeast to animals, new pathways and updates to the Database of Cell Signaling highlight how signals received at the surface are transmitted into the cell to mediate complex cellular responses.

Animals↗
PubMed2006

Assessing undergraduate laboratory performance.

The lab notebook is one element for assessing student laboratory performance. However, it is also important to be able to communicate research results in a journal article format and a visual poster format. Another key aspect to scientific research is the ability to present a research plan. This article describes four assessment tools that can be used in conjunction with undergraduate lab courses that provide the opportunity for the students to practice each of these essential communication skills.

Audiovisual Aids↗
PubMed2006

Differentiation of PC12 cells.

This 3-week-long series of collaborative laboratory exercises explores how to use a cultured cell system (PC12 cells) to study signaling pathways involved in cellular differentiation. The laboratory would be useful in a neurobiology or cell biology course for advanced undergraduate students. The background and details for performing the lab are provided along with suggestions for assessing student performance and understanding.

Animals↗
PubMed2006

Focus issue: measurement on a small scale.

This week's issues of Science and Science's STKE focus on how instrumentation is advancing investigation of biological questions. Science highlights how advances in detection methods are revealing the chemical aspects of biology, and STKE addresses techniques for single-molecule tracking and approaches to better understanding the interaction of cells with nanoparticles.

Computer Systems↗
PubMed2006

Focus issue: plant communication.

This week's issues of Science and Science's STKE focus on plant signaling with an emphasis on volatile organic compounds. Science emphasizes the chemistry of and information encoded by plant volatiles and how plants, plant pathogens, or humans utilize this aromatic information. Articles and resources at STKE highlight the evolution of olfactory signal transduction, describe the biosynthetic and signaling pathways of the plant hormone jasmonate, and provide an animated overview of how the plant hormone auxin regulates gene expression.

Arabidopsis Proteins↗
PubMed2006

Focus issue: signaling lipids.

Membranes are dynamic and specific contributors to cell signaling. Cellular membranes play a key structural role in creating sites for the formation of signaling complexes. Changes in membrane phospholipids can regulate the activity of transmembrane and peripheral membrane proteins. Modification of membrane lipids can result in formation of dynamic signaling molecules. Science's STKE highlights new insights into the roles that lipids and membranes play in cell signaling.

Animals↗
PubMed2006

2005: signaling breakthroughs of the year.

2005 was particularly notable for the range and scope of exciting advances in cell signaling research. Nominations from leading scientists ranged from plant signaling, neurobiology, and immunology to systems biology and structural biology. In plant biology, a new piece added to a long-standing puzzle in auxin signaling was discovered. The exploitation and regulation of RNA in cell signaling was also in the limelight. Intriguing new twists were highlighted in relation to functional and dysfunctional signaling in the brain, calcium-mediated signals, and the innate immune response. Finally, mathematical and statistical analysis of biochemical networks provided new insights into the circuitry of cell signaling pathways.

Biology↗
PubMed2005

Focus issue: signaling across membranes.

This week's issues of Science and Science's STKE focus on movement of molecules and information across cellular membranes. Science highlights the mechanisms by which proteins, ions, and DNA cross the membranes of eukaryotic and prokaryotic cells. STKE addresses how information is transmitted across cell membranes to allow cells to communicate with each other and to respond to signals in their environments.

Animals↗
PubMed2005

Focus issue: memories of signals past--plastic changes in nervous system function.

Plasticity encompasses the ability of the nervous system to adapt to injury and the ability of the developing and mature brain to change in response to experience. This week's Special Issue of Science focuses on systems-level approaches to understanding cortical plasticity, especially during development. The accompanying Focus Issue of Science's STKE features articles and resources that address issues related to the molecular changes that underlie synaptic plasticity in response to physiological or pathological stimuli.

Animals↗
PubMed2005

Cell signaling: from beginning to end.

The Connections Maps database and the graphical Web interface at Science's STKE for accessing the data represent an emerging Web-based tool through which researchers in cell signaling can share their knowledge with the scientific community. This tool provides a mechanism by which researchers, students, and clinicians can transform information about interactions between biomolecules into knowledge about a cellular process. In 2005, new Pathways were added to the Connections Maps database and several of the existing Pathways were updated.

Cooperative Behavior↗
PubMed2005

Focus issue: RNA, a multifunctional molecule.

This week's issues of Science, Science's STKE, and SAGE KE (www.sciencemag.org/sciext/rna/) focus on the increasing complexity that RNA brings to cellular biology. STKE resources include Reviews, Perspectives, and Teaching Resources. STKE specifically looks at the roles for small RNAs in regulation of gene expression and how mRNAs can be selectively activated from cytoplasmic macromolecular structures, RNA granules, to contribute to such processes as synaptic plasticity.

Animals↗
PubMed2005

Focus issue: drug discovery.

This week's issues of Science and Science's STKE focus on issues related to the development of therapeutics, including new methods for identifying drug targets and the goal of personalized medicine based on an individual's genetics. STKE specifically looks at the roles the RNAi can play in the drug target identification process, how understanding the genetics behind disease can lead to new options for therapeutic intervention, and how analysis of the signaling network may provide insight for personalized medicine.

Animals↗
PubMed2005

Signals from the past.

Science's STKE celebrates Science's 125th anniversary issue by presenting 12 notable articles from Science that highlight different aspects of cell signaling research.

Animals↗
PubMed2005

Teaching with STKE.

STKE has several mechanisms by which instructors and students can utilize the site as a teaching tool and resource. With the instructors of the "Cell Signaling Systems" course for graduate students, STKE explores using the various elements of STKE as a digital teaching aid. The resources that will be part of the STKE online supplement to the course as taught at Mount Sinai School of Medicine, New York, NY, include Teaching Resources starting with one that outlines the course structure and schedule and then one for each lecture. In addition, related resources at STKE will be highlighted in and linked to the Teaching Resources. The final component will be online discussion forums that allow students and instructors the world over to interact with the instructors of this course, which is offered in a traditional classroom format at Mount Sinai School of Medicine.

Education, Medical↗
PubMed2004

Teaching resources. Spatial and temporal dynamics of signaling components involved in the control of chemotaxis in Dictyostelium discoideum.

This animation shows the redistribution of several proteins during the chemotactic response of the single-celled organism Dictyostelium discoideum to the chemoattractant cAMP. Much like neutrophils, this organism is able to sense and move toward very shallow gradients of chemoattractant. Mutant strains carrying mutations in genes encoding various signaling components are available and, thus, D. discoideum serves as a model organism for the study of the cellular mechanisms that control chemotaxis and amplification of a signaling gradient across a single cell. The animation would be useful in depicting the dynamic nature of signal transduction, the ability of cells to polarize to allow for directional movement, and the spatial and temporal changes in the activity of specific proteins that accompany chemotactic responses.

Animals↗