Biomedical subjects

Nabil El-Sherif

Publications and source records attributed to Nabil El-Sherif.

21 records · Page 2Linked to original sources

PubMed2002

Location and clinical implications of high-degree atrioventricular block during dipyridamole infusion: a case report.

We describe a patient with bifascicular block, who developed transient high-degree atrioventricular block during dipyridamole infusion. This patient was subsequently found to have significant His-Purkinje disease at electrophysiology study, and underwent permanent pacemaker implantation. Spontaneous atrioventricular block was documented during follow-up. This case report raises the issue of dipyridamole safety in patients with intraventricular conduction defects, and contributes an additional mechanism to the possible explanation of dipyridamole-induced atrioventricular block.

Aged↗

PubMed2002

Efavirenz-associated QT prolongation and Torsade de Pointes arrhythmia.

OBJECTIVE: To report a case of acquired long QT syndrome that, after exclusion of all other possible causes, was probably related to therapy with efavirenz, a novel nonnucleoside reverse transcriptase inhibitor. CASE SUMMARY: This patient presented with recurrent syncope and polymorphic ventricular tachycardia, which was treated with overdrive ventricular pacing and was eliminated by discontinuation of the offending drug. DISCUSSION: This is the first reported case of QT prolongation and severe ventricular arrhythmia associated with the use of efavirenz. The temporal relationship between the initiation of treatment and the onset of electrocardiographic abnormalities, the absence of other apparent precipitating factors, as well as the normalization of QT interval and the resolution of the arrhythmia after discontinuation of the drug, strongly suggest a causal relationship between efavirenz and this adverse clinical event. CONCLUSIONS: Our case shows that any new pharmaceutical compound introduced in clinical practice may potentially result in QT prolongation and life-threatening arrhythmia.

Alkynes↗

PubMed1994

Cardiac Electrophysiology in the Older Population.

There is increasing evidence that significant primary alterations of cardiac electrophysiologic properties occur with the normal aging process. The age-related changes in cardiac electrophysiologic parameters are seen as alterations in the surface electrocardiogram, depressed sinus and atrioventricular nodal function, and increased refractoriness of the cardiac tissue. The mechanisms underlying these changes may consist of structural changes of the conduction system, autonomic nervous system dysfunction, or changes in cellular electrophysiology. As a result of these changes, the responsiveness of the aging heart to cardiotropic drugs is different from that of the younger heart. Elderly subjects are prone to certain electrophysiologic syndromes that merit special consideration.

Journal Article↗