Pitted keratolysis is a superficial infection of the skin confined to the stratum corneum. The causative organism has not been identified. The clinical syndrome is distinct and is characterized by pits and superficial erosions in the pressure areas of the soles and in the lateral surfaces of the toes. The histopathology of the lesions is presented and world literature is reviewed. It is concluded that this disease is not limited to the tropical climates, although cases tend to be more severe in these areas.

Humans↗

PubMedDate not supplied

Tinea pedis: the child and the family.

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Adult↗

PubMedDate not supplied

The treatment of dermatophytoses of the glabrous skin: a comparison of undecylenic acid and its salt versus tolnaftate.

In a double-blind study, the efficacy of 1% tolnaftate cream, 3% undecylenic acid and its zinc salt, and a placebo cream were tested in dermatophytosis of the glaborous skin and groin. Ninety-seven subjects completed the study: 33 received tolnaftate, 23 of these subjects were cured clinically and mycologically. Thirty-two subjects received 3% undecylenic acid and 20% zinc undecylenate as a cream. Of these, 21 were cured clinically and mycologically. Only three of the 32 subjects receiving placebo were cured clinically and mycologically. Both tolnaftate and undecylenic acid and its zinc salt are effective in this condition.

Clinical Trials as Topic↗

PubMedDate not supplied

Malathion lotion as an insecticide and ovicide in head louse infestation.

A lotion containing 0.5% malathion was compared with its vehicle (control) in a double-blind, parallel-group study of 119 patients with head louse infestations confirmed by live ova in the hair. The lotions remained in place for 8 hours. The test preparation was superior to the control lotion by a highly significant margin (p less than 0.001) as determined by the numbers of patients with live lice at 24 hours and 7 days after removal of the respective materials. It also proved superior to the vehicle (p less than 0.001) as an ovicidal agent, judged by comparative differences in hatching rates between nits collected and incubated before treatment and those obtained and incubated after treatment. No adverse reaction occurred.

Administration, Topical↗