Search PubMed⌕ Search

Biomedical subjects

N Yasuda

Publications and source records attributed to N Yasuda.

At least 325 records · Page 18Linked to original sources
PubMed1982

[4-META resins].

Explore the source record for details and available documents.

Acrylic Resins↗
PubMed1981

Hypoglycemia stimulates ACTH secretion through a direct effect on the basal hypothalamus.

The primary site of action of insulin hypoglycemia to induce ACTH secretion was investigated in rats with medial basal hypothalamic ablation (MBHA), medial basal hypothalamic deafferentation (MBHD), and chlorpromazine-morphine-pentobarbital (C-M-P) treatment. Plasma corticosterone (B) concentration was used as an index of ACTH secretion. Hypoglycemia failed to provoke ACTH secretion in MBHA and C-M-P treated animals, while it stimulated ACTH secretion in MBHD animals to the same extent as in controls. The rise in plasma B induced by synthetic lysine-vasopressin injection was not significantly different between MBHA and control animals, indicating pituitary ACTH reserve was not affected by the operation. Our data indicate that hypoglycemia stimulates ACTH secretion through a primary effect in the medial basal hypothalamus and not in the extrahypothalamic CNS or adenohyphophysis.

Adrenocorticotropic Hormone↗
PubMed1981

Non-specific adsorption of corticotrophin-releasing factor (CRF) to powdered glass.

CRF activity from various sources (rat hypothalamic median eminence and posterior pituitary, bovine hypophyseal stalk, and human peripheral blood) was adsorbed to finely ground glass (Quso, Corning, CRF activity was eluted from the glass with 30% acetone. Up to 85% of the total CRF activity originally present in the crude CRF preparation was adsorbed to Quso or Corning glass; up to 25% of the original total CRF activity was recovered from the glass with 30% acetone. We conclude that CRF is among the hormones adsorbed by glass.

Adrenocorticotropic Hormone↗
PubMed1981

J chain synthesis in lymphocytes from patients with selective IgA deficiency.

J chain synthesis was investigated by in vitro pokeweed mitogen (PWM) stimulated peripheral blood lymphocyte (PBL) cultures in eight patients with selective IgA deficiency and compared with that of normal persons. In normals, all IgM-containing cells always had the J chain but only in a portion of IgG- and IgA-containing cells was J chain detectable. The percentage of J chain-positive cells amongst IgG or IgA cells increased during culture, reached a peak at days 5-6 or 6-7, respectively, and then decreased. IgA-deficient patients had very few IgA-containing cells and an increased number and percentage of J chain-positive IgG cells, except for one patient, who had a significant number of IgA-containing cells without IgA secretion into the culture supernatants. Measurement of Ig in culture supernatants by radioimmunoassay revealed that lymphocytes from seven patients secreted significantly smaller amounts of IgG and IgM than did the normal controls, in addition to the defect in IgA production. These results suggested the presence of some ontogenetic relationship between J chain-positive IgG cells and the precursors of IgA-producing cells, and some functional immaturity of most IgG-producing clones seen in patients with selective IgA deficiency.

Cells, Cultured↗
PubMed1980

No sex difference in mutations rates of Duchenne muscular dystrophy.

Segregation analysis was performed to evaluate possible differences in mutation rates in man. It was based on 514 males with Duchenne type muscular dystrophy (DMD) from five of nineteen hospitals for muscular disease in Japan. The estimated proportion of sporadic cases (new mutations) was 0.29 +/- 0.046, which is in excellent agreement with the expected 0.333 if there is no sex difference in mutation rates. The rate of mutation was estimated to be 6.3 X 10(-5) per generation. The incidence and prevalence rates among males were estimated to be 217 X 10(-6) and 49.9 X 10(-6), respectively.

Humans↗
PubMed1980

J chain synthesis in human myeloma cells: light and electron microscopic studies.

The presence of J chain in human immunocytes containing various immunoglobulin classes has already been reported and in this paper we investigated the presence of J chain in human myeloma cells using light and electron microscopy. Myeloma cells were positive for cytoplasmic J chain in thirteen cases: six of fifteen IgG myeloma, two of seven IgA myeloma, two of nine B-J myeloma and three of three primary macroglobulinaemia. None of the four with benign monoclonal gammopathy was positive for J chain. The ultrastructural localization of J chain in IgG myeloma cells was similar to that of gamma chain, i.e. around the nuclear membrane, in the endoplasmic reticulum (ER) and in the Golgi apparatus. The latter finding is compatible with the presence of J chain in the urine of the same patient. We examined the urine from nine patients with J chain-positive cells and secretion of J chain was confirmed in three patients: two with IgG myeloma and one with B-J myeloma. In noe of twelve in whom the immunocytochemical findings were negative for J chain was there evidence of urinary J chain.

Cytoplasm↗