Simple mice test antibody complexity.
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Biomedical subjects
Publications and source records attributed to N Williams.
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Peripheral parenteral nutrition is an attractive alternative to centrally delivered parenteral nutrition because it obviates the need for central venous cannulation and its attendant complications. Some 45 consecutive patients were fed peripherally using a 22-G polyurethane catheter and a fat-based, low-osmolality feed. Of these patients, 36 were fed for a median of 8.5 (range 3-31) days without peripheral vein thrombophlebitis (PVT). Seven patients developed PVT after a median of 6 (range 5-7) days. The cumulative daily risk of PVT was 0.016 episodes per day. These results suggest that prolonged (more than 7 days) problem-free peripheral parenteral nutrition is possible.
We report the results of a postal questionnaire sent to a group of women who had sustained major pelvic fractures and sacroiliac disruption. The findings suggest that a large proportion of women suffer sexual dysfunction after such injuries. This is an important and previously neglected sequel of pelvic injuries.
Glycated haemoglobin (Hb A1c) was used as a marker of long-term hyperglycaemia in patients receiving high glucose loads for home parenteral nutrition (HPN). Thirty-six patients received a median weekly glucose delivery of 2000 g (800-4200) at a median infusion rate of 11.8 mg/kg/min (5.0-19.2). There was no correlation between Hb A1c (median- 3.1%, range 2.0-6.3%) and glucose infusion rate or weekly glucose load. It is concluded that significant prolonged hyperglycaemia does not appear to be a problem in patients on HPN managed by this unit.
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Between 1993-1995 a cross-sectional survey of 20 chrome plating companies in the West Midlands was undertaken to assess the prevalence of respiratory and dermatological disease in platers. By means of a questionnaire and clinical examination 71 platers were examined of whom 23% were found to have dermatitis at the time of the visit and 45% of companies had at least one case of dermatitis in their plating workforce. Twenty-three per cent of platers had evidence of old chrome ulceration and 13% had evidence of new and healing chrome ulcers. When the nasal passages of platers were examined 17% had inflammation and 14% had septal perforation. Those with perforations were aged less than 35 years at the time of perforation which had usually occurred in the first 10 years of exposure. Lower respiratory symptoms were rare. Guidance on the prevention of disease in this occupational group which does not always have ready recourse to experienced occupational medical advice will be discussed.
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