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Biomedical subjects

N Weiss

Publications and source records attributed to N Weiss.

At least 181 records · Page 10Linked to original sources
PubMed1976

[Comparative studies on the immunodiagnosis of filariasis (author's transl)].

Four serological methods have been evaluated for the immunodiagnosis of filarial infections in European patients returning from endemic areas. The highest sensitivity was found by the immunoelectrophoresis (73%), followed by the indirect fluorescence antibody test (60%) and the indirect hemagglutination (57%). The reliability of the two-dimensional geldiffusion was rather low (41%). Using immunofluorescence and hemagglutination procedures simultaneously 83% of all pathologic filarial infections were detectable. Adding an immunoelectrophoretic analysis to those sera which give doubtful results a final sensitivity of 88% was attained.

Filariasis↗
PubMed1975

Characteristics of menopausal women: a survey of King and Pierce counties in Washington, 1973-2974.

Age-specific menopause rates, frequency and duration of menopausal estrogen use, and characteristics of users and non-users of menopausal estrogen therapy are presented for the population of King and Pierce counties in the state of Washington from 1973-1974 survey data. Age-specific menopause rates do not differ substantially from rates derived from data from the 1960-1962 US Health Examination Survey, although women over 50 years of age were more likely to report operative menopause in the present study than in the Health Examination Survey. The estimated frequency of menopausal estrogen use of over 3 months' duration in the population was 51%; this is in contrast to an estimated 26% rate of severe menopausal symptoms. Median use of menopausal estrogen therapy was over 10 years. Estrogen users were younger than non-users and reported more formal education. More users had had difficulty with severe menopausal symptoms and more had had a hysterectomy.

Adult↗
PubMed1975

Pyridoxine treatment of childhood bronchial asthma.

Urinary xanthurenic and kynurenic acid levels were measured in five patients while they were receiving 50 mg and 100 mg of pyridoxine. The levels of tryptophane metabolite decreased progressively as the dose was increased but remained above basal levels. There was marked clinical improvement in these patients while receiving the higher dose only. The double-blind study with 76 asthmatic children followed for five months indicated significant improvement in asthma following pyridoxine therapy (200 mg daily) and reduction in dosage of bronchodilators and cortisone. The data suggest that these children with severe bronchial asthma had a metabolic block in tryptophane metabolism, which was benefitted by long-term treatment with large doses of pyridoxine.

Adolescent↗
PubMed1975

Identification of T. brucei-subgroup strains isolated from game.

Several T. brucei-subgroup strains isolated from game were investigated with the blood incubation infectivity test (BIIT) and in human volunteers. Original isolates and their clones derivatives were tested. In order to check the validity of the BIIT, volunteer tested clones were used under modified BIIT conditions. Inoculation of different trypanosome strains into volunteers yielded positive parasitaemia for original isolates from lion, hyaena, and Coke's hartebeest. Changing antibody titers during the course of infection in the volunteers were checked with the indirect fluorescent antibody test (IFT). The BIIT WAs reliable (consistently positive) for cloned T. b. rhodesiense. When testing T. b. brucei, the BIIT results depended on the number of incubated parasites and on the parasitaemia peak number the tested trypanosomes derived from. It was further shown that the in vivo part of the BIIT is actually essential for the complete neutralization of T. b. brucei induced by the action of human plasma. Tests with trypanosomes originating from experimentally mixed T. b. rhodesiense and brucei infections gave inconsistent results. On the other hand, pure populations mixed in vitro-prior to incubation for BIIT-revealed results depending on the proportion of the 2 species: up to 20% T. b. rhodesiense gave negative, higher concentrations consistently positive results.

Animals↗