Search PubMed⌕ Search

Biomedical subjects

N W Goodman

Publications and source records attributed to N W Goodman.

At least 19 recordsLinked to original sources
PubMed2002

Remifentanil by patient-controlled analgesia compared with intramuscular meperidine for pain relief in labour.

BACKGROUND: The pharmacokinetics of remifentanil suggests that it may be suitable for analgesia during labour. METHODS: In an open pilot study, 36 women requesting meperidine for analgesia were recruited early in labour and randomized to receive either meperidine i.m. or remifentanil given as patient-controlled analgesia (PCA). Pain severity, sedation and anxiety were assessed with visual analogue scales and overall effective analgesia was assessed by the woman and midwife. RESULTS: The pain scores were lower in the remifentanil group: median pain score at 60 min was 72 mm for meperidine and 48 mm for remifentanil (P=0.004) and median maximum pain score during the first 2 h was 82.5 mm for the meperidine group and 66.5 mm for the remifentanil group (P=0.009). Both the midwives' and the women's assessments of overall effective analgesia were higher in the remifentanil group [Likert scale (5 = excellent to 1 = poor): chi2=12.10, P=0.002 for mothers' assessment; chi2=12.80, P=0.002 for midwives' assessment]. CONCLUSION: In this pilot study, remifentanil by PCA gave better pain relief to mothers in labour than intramuscular meperidine. However, remifentanil is a potent respiratory depressant and adequate continuous monitoring is necessary.

Adolescent↗
PubMed2001

How to write a critical letter and respond to one.

Critical letters are important. They correct the published record. To write a critical letter requires tact; to respond to one requires tact--and the humility that comes with the realisation that belief in an observation or an idea does not make it true.

Correspondence as Topic↗
PubMed2001

Evidence-based medicine and anaesthesia.

The author defines the concept of Evidence-Based Medicine as the collection of data from large trials and their analysis. In Anesthesia and medicine in general the wide heterogeneity of the patients can make the statistical results difficult to interpret and conclusions should be drawn carefully.

Anesthesiology↗