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N Vucković

Publications and source records attributed to N Vucković.

At least 19 recordsLinked to original sources
PubMed1996

Routine jejunal endoscopic biopsy in children.

UNLABELLED: The aim of the study was to evaluate and compare two methods of jejunal biopsy-endoscopic (EB) and suction (SB). Jejunal EB was performed using an Olympus GIF P20 endoscope in 119, and SB with a modified Crosby capsule in 254 patients. A light microscope with micrometer was used for the analysis and measurement of biopsy specimens. Calculated per patient, the total average number of all adequate specimens was: jejunal or duodenal mucosa -2.97 in EB and 0.93 in SB; jejunal mucosa only -2.82 in EB and 0.89 in SB group. Duodenal mucosa was unintentionally biopsied in 17.1% of EB and in 3.7% of SB. Jejunal mucosal specimens were selected for measurement at random -82 from the EB and 24 from the SB group. The difference in height between EB and SB specimens was not significant (EB: 0.72 +/- 0.13 mm; vs SB: 0.77 +/- 0.14 mm). The difference in length was significant (EB: 2.57 +/- 1.24 mm; vs SB: 3.22 +/- 1.38 mm; P = 0.03). The advantages of the EB over the SB technique included elimination of fluoroscopy, no failures in obtaining biopsies and a 97% success rate in obtaining specimens adequate for histological analysis. It also enabled the biopsy site to be chosen and several specimens to be taken, providing additional tissue for various analyses. CONCLUSION: Jejunal endoscopic biopsy is suggested as a good alternative to the suction biopsy, wherever paediatric upper gastrointestinal endoscopy is available.

Adolescent↗
PubMed1996

[Atherosclerotic plaque hemorrhage as one form of a complicated atherosclerotic lesion].

Atherosclerotic plaque hemorrhage is a form of a complicated atherosclerotic lesion. It is a finding of extravasation of erythrocytes (fresh hemorrhage) or siderophages (old hemorrhage) in the defined atherosclerotic changes. 510 segments of the main epicardial coronary arteries (right coronary artery, anterior interventricular branch of the left coronary artery, circumflex branch of the left coronary artery) were microscopically examined in 50 obduction cases of patients with ischemic heart diseases. Fresh hemorrhage in the atherosclerotic plaque was established in 25 cases, that is in 40 microscopically examined coronary artery segments. It was established in all cases where there was a atherosclerotic plaque rupture, in some segments where process of thrombotic organization occurred, as well as in some segments of arteries which supply the region of early myocardial infarction. All hemorrhages occur inside lipidic and fibrolipidic atherosclerotic changes of intima. The average length of fresh hemorrhage was 0.8 cm. 92.50% of segments with fresh hemorrhages occur in the first 4 cm of the examined arteries. 88% of plaque hemorrhages occur in segments with 76-100% lumen obstruction. Signs of old hemorrhages most often occur in segments with 51-75% and 76-100% lumen obstruction. Siderophages mostly occur in complicated atherosclerotic changes and thrombotic organization.

Coronary Artery Disease↗
PubMed1996

[Sociodemographic and epidemiologic characteristics of hospitalized alcoholics in Vojvodina].

Using the Register of hospitalized alcoholics in Vojvodina we analyzed data on sociodemographic and epidemiologic characteristics of the alcoholic disease. This retrospective study, using longitudinal and anamnestic data during a three-year period (1991-1993) deals with all patients treated for Alcohol Dependency Syndrome (according to the International classification of diseases, IX revision) treated at neuropsychiatric institutions in Vojvodina and living on this territory. The sample consisted of 4783 examinees. The gathered results indicate that there is a decrease in number of patients treated for alcoholic disease, that is in incidence, prevalence and risk of morbidity in regard to the population of the examined territory. As this decrease is associated with a decreased number of registered psychiatric, neurologic, and somatic complications of the alcoholic disease, the authors may conclude that the intensity of actual social pathology and social disorders, which are characteristic for the above mentioned period resulting in the decrease of production and consumption of alcohol, decreases alcoholism and its complications.

Adult↗
PubMed1996

[Calcification in atherosclerotic plaque as one of the types of complicated atherosclerotic lesions].

Calcifications of the atherosclerotic plaque is the form of a complicated atherosclerotic lesion. It is characterized by granular or massive deposits of calcium chloride inside the atherosclerotic plaque. It was found in at least one of the three main coronary arteries in 43 (86.00%) out of 50 autopsy cases. In all three, coronary arteries calcifications were found in 8 (18.60%) cases, in two coronary arteries in 19 (44.19%), and one coronary artery in 16 (37.21%) cases. Calcifications of atherosclerotic changes which contain fats were statistically significantly more frequently established than those which did not contain fats. In three fourths of cases calcifications were present in segments with significant narrowing of the arterial lumen (group 3 and 4). In 59.61% of calcificated atherosclerotic changes the residual lumen was of eccentric shape, in 20.51% of concentric shape, in 7.69% it was semilunar, and in 12.18% a few lumens were detected (channeled and organized thrombi). Granular deposits of calcium were established 63.46%, while massive in 36.54% of segments of atherosclerotic lesions, but no statistically significant difference in distribution of these two types of calcifications was established in regard to the type of atherosclerotic change.

Aged↗
PubMed1996

[The hypophyseal-adrenal axis in chronic alcoholism].

In order to reveal the morphologic basis of clinically recognized pseudo Cushing syndrome in chronic alcoholism, we performed an analysis of histologic characteristics of hypothalamo-hypophyseal adrenal axis components. The experiment included Wistar rats which were given 15% ethanol solution in water for three months. By methods of classical histology, histochemistry and immunofluorescence adrenal and hypophyseal sections of experimental animals exposed to continual effects of alcohol and those from the control group were examined. ACTH (adrenocorticotropin) cells of the experimental group show expressed immunofluorescence as a proof of their high secretory granules present in numerous cytoplasmic endings which contribute to significantly increased number of these cells comparing to the control group. In the adrenal cortex of animals exposed to alcohol, in the zona fasciculata and zona reticularis, under the influence of hypophyseal corticotropin (ACTH) secretion, there is a statistically significant increase of the compact cells region, as synthetic active elements, in regard to vacuolized cells, as inactive elements, which has been established stereologically. Simultaneous hyperfunction of hypophyseal ACTH cells and ACTH dependent zones of the adrenal cortex in chronic alcoholism, proves that alcohol primarily acts at the level of hypothalamus and hypophysis, while adrenals react to hypersecretion of ACTH cells. The way alcohol affects neurotransmitters is the topic of the discussion, whereas stimulated synthesis of acetylcholine is pointed out.

Adrenal Cortex↗
PubMed1995

[Pathohistologic changes in aortocoronary venous grafts].

This paper analyses histological changes of venous grafts in 52 obduction cases who had undergone aortocoronary bypass grafting and in whom death occurred after more than 30 days from surgery. The group consisted of 46 males and 6 females. The mean age at the moment of surgery was 51.5, while on the average the patients lived 4.83 years after the surgery. 144 venous grafts were implanted, that is 2.77 per patient. In 49 (34.03%) venous grafts fibrosis intima was established. As in 43 (29.86%) grafts it did not cause occlusion of the lumen greater than 25%, these kinds of grafts were marked as unchanged, normal. In 43 (29.00%) grafts atherosclerosis was established, in 14 (9.72%) fibrointimal proliferation, and in 38 (26.39) lumen obliteration. A year after the surgery the most important pathohistologic change was fibrointimal proliferation, and two years after the surgery and on-atherosclerosis. The percentage of certain pathohistologic types of graft changes, no matter how long patients survived after the surgery was the same in both patients with implants of the coronary artery and those with anterior interventricular branch of the left coronary artery. Grafts implanted into branches of the circumflex artery were statistically significantly more often obliterated. The locality of anastomosis of the venous graft and artery was not occluded in 67.31% of all obduction cases, whereas it was occluded in 32.69% of cases or 32 (22.22%) implanted grafts. Occlusions were caused by atherosclerotic change of the anastomosis in 84.37% of grafts, and by simultaneous occurrence of atherosclerotic change and thromb in 15.63% of grafts.

Coronary Artery Bypass↗
PubMed1995

[Analysis of the cause of death in patients with aortocoronary bypass implants].

This paper analyzes causes of death in 91 autopsied patients in whom aortocoronary bypass surgery was performed as a therapy of ischemic heart disease. Patients who died within 30 days after surgery made up the group of so-called "early deaths", while those who died 30 or more days after the surgery made up the group of so-called "late deaths". The leading cause of death in the group of "early deaths" was myocardial infarction (51%) and then causes of death connected to other systems of organs (38%). Hematopericardium and consequential cardiac tamponade was the cause of death in 8% of cases, while in 3% of cases it was cardiac decompensation. In the group of "late deaths" the most important cause of death was myocardial infarction (56%), and then cardiac decompensation (27%), as well as causes of death connected to other systems of organs (17%).

Cardiac Tamponade↗
PubMed1995

[Correlation of postmortem coronarography and the macroscopic and microscopic determination of luminal narrowing of coronary arteries in ischemic heart disease].

In our work we used 30 consecutive abduction cases of individuals suffering from ischemic heart disease. Postmortal coronarography was performed in all and we examined the narrowness of artery lumen, its degree, existence and locality of the obturatory thrombus, artery domination, state of aortocoronary grafts and the existence of anastomoses. Coronary arteries were macroscopically examined by cuts on every 0.5 cm of the established aims, and then segments were examined microscopically. The gathered results were compared and the degree of agreement of the two methods was calculated. An agreement of 100% was established when determining artery domination and presence of obturatory thrombus, although the number of found thrombi was bigger when macroscopic/microscopic examination was done. The defined degree of artery lumen narrowness was identical in 75% of cases.

Aged↗
PubMed1994

[Specific inflammatory processes in collagenosis, degenerative and malignant diseases of the skin of the face and neck during aging].

214 skin lesions have been analyzed in the paper and 158 cases of Carcinoma basocellulare, 22 cases of Carcinoma planocellulare and 11 cases of melanoma were registered. Concerning localization it has been established that skin of the face is mostly endangered both for malignant and benign lesions. In 10 cases Keratosis senilis, a benign kind of lesion, was diagnosed, Dermatitis post irradiationem was diagnosed in 8 cases and Lupus erythematodus in 5 cases. By histologic analysis the following can be stated: if the degree of degradation and damage of collagen fibers is high, the intensity of lymphoplasm infiltrate density and intensity of mastocyte cells density is reduced. If the degree of decomposition of collagen fibers is lower, the lymphoplasmocyte infiltrates are denser as in the stroma of the lesion as well in edges and in the surrounding dermis. Changes were primarily found in malignant skin lesions, but they are identical in cases of keratosis senilis as a premalignant lesion. However, concerning nonmalignant lesions, depending on exterior factors, long time influence of noxa, collagen fibers and their degree of degradation have an important role in the cell interaction, and more attention should be paid to exploring decomposition of collagen fibers as components of the local immunobiologic reaction of the organism to lesion formation.

Facial Dermatoses↗
PubMed1994

[Types of atherosclerotic changes in relation to the type of residual lumen and degree of narrowing in coronary arteries in ischemic heart disease].

510 segments of all three coronary arteries in 50 obduction cases of individuals suffering from ischemic (coronary) heart disease were microscopically examined. We examined the type of atherosclerotic change, the degree of narrowness of lumen artery and the type of residual lumen. In the group one of the narrowness of artery lumen 44 segments with fibrotic plaque were found, where concentric shape of lumen dominates. In the group two of the narrowness 176 segments were found. Most of them were with fibrotic plaque, but complicated atherosclerotic lesions were also present. According to the shape of residual lumen the concentric narrow shape dominates. In the group three of the narrowness of the lumen 191 segments were found; considering the type of atherosclerotic change complicated lesions were most common, while lipidic plaque was also present. An eccentric shape of residual lumen dominates this group. In the group four of the narrowness of lumen artery 99 segments were found; in this group we found fibrotic plaque and complicated atherosclerotic lesions. The most common finding of the residual lumen is the type of multiple lumen (channelled thrombi).

Coronary Artery Disease↗
PubMed1993

[Analysis of the relation between socioeconomic factors and suicidal behavior].

The paper explores case histories of 128 patients hospitalized for suicide attempts at the Institute of Neurology, Psychiatry and Mental health in Novi Sad for a period of two years. The analysis of relevant suicidological data was carried out with the aim of determining the significance which SOCIOECONOMIC factors play in gene-rating suicidal behavior. Under the item "occupation/employment" most frequent were "workers" 21.88 per cent, followed by unemployed persons--17.19 per cent, while those on social welfare constituted 16.4 per cent. Financial poverty as the motive for suicide attempt is most often encountered among unemployed ones and those on social welfare. In the total sample, this poverty was registered in 19 cases (14.84 per cent). It is interesting that this motive is more often present in younger persons, where mean age for those on social welfare is 28 and for the unemployed ones is 29 years. The diagnosis most often found in these groups is "Adjustment Disorder with Depressed Mood (309.00)", no psychotic episodes were found. With respect to alcohol dependence, it is much less present among those on social welfare than in the rest of the sample. Therefore, financial poverty is not negligible factor of suicide risk. This finding directly confirms that financial poverty as suicide generator has so far not been researched sufficiently or is evidently on the rise, at least in our society.

Adult↗
PubMed1991

[Familial hemophagocytic lymphohistiocytosis].

The paper presents two cases of familial hemophagocytic lymphohistiocytosis in one family. The first case is the first-born female child with symptoms of an abrupt onset of hepatic failure and encephalopathy at the age of 2.5 months, and the second case is the third-born male child from the fourth pregnancy who died in his first month with a similar clinical manifestation. By means of histological examination, a diffuse proliferation of histiocytes of benign appearance with numerous phagocytized erythrocytes in the cytoplasm was found in both patients. These infiltrates existed in numerous organs and tissues of the body, but they were mostly visible in the spleen, liver, lymph nodes and in the bone marrow. The course of the disease is rapidly progressive with an up to now insufficiently explained etiology of the disease, with the existence of an autosomal recessive type of inheritance and defects in cellular and humoral immunity.

Female↗
PubMed1991

[Cystic teratoma of the neck].

Teratomas of the neck are very rare, and up to now only a small number of cases has been described (10 in adults), while in children it is a more frequent finding (132 described cases). It is judged that up to 4% of all teratomas in children are located in the cervicothyroid region. The paper presents a case of a cystic teratoma of the neck in a male child of 1.5 years of age, which gradually increased in it's size during the course of 12 months prior to operation. The tumor had the dimensions 3.7 x 3.2 x 2.7 cm, it was multicystic, and clinically it gave the impression of a bronchial cyst. Histologically the tumor contained elements of all three primary embryonic germ layers.

Dermoid Cyst↗
PubMedDate not supplied

Thyroid/cervical teratomas in children: immunohistochemical studies for specific thyroid epithelial cell markers.

Pathological and immunohistochemical findings for specific thyroid epithelial cell markers in thyroid/cervical teratomas from four children are reported. All tumors showed components from the three germinal cell layers. Neoplastic thyroglobulin-immunoreactive thyroid follicles occurred in three intrathyroid teratomas, but the findings were negative in a cervical teratoma in which evidence of its thyroid origin could not be ascertained. As previously suggested on histological grounds, thyroid tissue, other than normal trapped thyroid follicles, is not an infrequent component of cervical teratomas. We found no evidence to support an ultimobranchial origin for these tumors, as previously suggested by Roediger et al. (19), because no calcitonin immunoreaction was observed.

Biomarkers, Tumor↗
PubMedDate not supplied

[Persistent dyschromic erythema].

INTRODUCTION: Erythema dyschromicum perstans (ashy dermatosis) is a very rare skin disease included in the group of acquired, idiopathic hypermelanosis, with development of blue-gray macules. This disease appears more frequently in dark coloured persons, especially women in the first and second life decade. CASE REPORT: A male patient, 42 years of age, was admitted to Clinic of Dermatovenereology in Novi Sad due to appearance of slightly pruriginous, brown-reddish macules on the trunk, upper and lower extremities, without affecting the skin of the face, scalp, palm soles and visible mucous membranes. Later, the color of the macules changed into blue-gray and new lesions appeared in axilla and flexor side of the big joints, with active, erythematous and thin raised borders. Laboratory findings showed no abnormalities; antinuclear antibodies were negative. Histopathological examination of the skin specimens (which were taken from two different places) showed vacuolar degeneration of the basal cell layer, numerous pigmentophages in papillary dermis and presence of lymphohistiocytic infiltrate in dermis. No history of drug intake or exposure to UV light was established. DISCUSSION: Ashy dermatosis is included in the group of hypermelanosis of unknown origin. As possible etiological factors we can mention ingestion of ammonium nitrate, environmental pollution, hypersensitivity to cobalt chloride and postinflammatory pigmentation. Clinical characteristics: occurrence of blue-gray and gray macules on the trunk, face, neck and extremities (absence on the palms, soles, visible mucous membranes, scalp and nails). In the active phase of the disease, these macules are surrounded by erythematous and thin, raised borders. The lesions are mostly permanent. Due to clinical, histopathological, immunofluorescent and electron microscopy established similarities with lichen planus, it is considered that ashy dermatosis is a variant of lichen planus. Absence of previous drug intake, exposure to UV light, absence of the antinuclear antibodies, clinical picture and histological findings confirm the diagnosis of erythema dyschromicum perstans. CONCLUSION: This case of ashy dermatosis shows that there is a need for differential diagnosis of acquired skin pigmentations, because this dermatosis must also be taken into consideration.

Adult↗
PubMedDate not supplied

[Small-plaque parapsoriasis: case report].

INTRODUCTION: Small plaque parapsoriasis is a relatively rare, chronic, idiopathic dermatosis, most often seen in middle age people. This disease shows a definite male predominance of approximately 3-4: 1. It is characterized by presence of round or oval erythematous, slightly scaly plaques on the limbs and trunk, which histologically reveal mild eczematous changes. CASE REPORT: A male patient, 61 years of age, was admitted to the Clinic of Dermatovenereology in Novi Sad due to long persisting erythematous patches on his upper and lower limbs. Plaques were of oval and round shape, pretty well marginated. They were of light red colour, covered with fine scales with a slightly wrinkled surface. He complained of itching. Laboratory findings showed no abnormalities. Histopathologic examination of the skin specimen revealed epidermal atrophy, focal parakeratosis, perivascular dermal infiltrate of mononuclear cells with exocytosis in the epidermis. This finding was compatible with the clinical diagnosis. After treatment with topical corticosteroid cream combined with whole body exposure to sunlight irradiation, vast majority of skin lesions regressed. DISCUSSION: The clinical course of small plaque parapsoriasis is very long. The plaques are remarkably stubborn, responding to treatment with steroid creams or to natural or artificial sunlight, but usually reappearing promptly when treatment is discontinued. The patches increase in number for a time, and then remain relatively constant for a long time. A small minority of cases clears entirely. Recent studies provided evidence of monoclonality and immunophenotypic abnormalities. Rearrangement of T-cell receptor genes was demonstrated by using PCR method. Detection of monoclonal T-cell populations in skin lesions, as a characteristic of lymphoproliferative diseases, forced some authors to include this dermatosis into a group of abortive cutaneous T-cell lymphomas. CONCLUSION: This case deserves a long and probably life-long clinical and histological assessment, especially due to new knowledge about the possible nature of this disease.

Humans↗