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Biomedical subjects

N Vasilev

Publications and source records attributed to N Vasilev.

71 records · Page 4Linked to original sources
PubMed1981

[Changes in the meningogram during amethopterin treatment of meningosis leucaemica].

The authors examined the changes in the morphology of leucaemic lymphoblasts, obtained from cerebrospinal fluid and changes in the cellular content of meningograms after treatment of Meningosis leucaemica with amethopterin. On the basis of the degree of cytoplasmic and nuclear damage paraleucoblasts were divided into three types: Type I - undamaged paraleucoblasts Type 2 - paraleucoplasts with a slight degree of damage, mainly cytoplasmic Type 3 - parleucoblasts with grave degree of damage, mainly nuclear. In the course of the therapy there was a reduction of the number of nondamaged leucaemic cells, which was accompanied with an increase in the number of damaged leucaemic lymphoblasts, lymphoids, lymphocytes and neutrophils. The damage of paraleucoblasts as well as the difference in the ratio of single cellular elements showed dependence on the number of intrathecal applications of the cytostatic. The described cytologic criteria could be used for prescription, control and checking the effect of intrathecal treatment of Meningosis leucaemica with amethopterin.

Cerebrospinal Fluid↗
PubMed1977

[Nuclear bodies of lymphocytes in the lymph nodes of guinea pigs treated with phytohemagglutinin in vivo].

Nuclear bodies (NB) were studied in guinea pigs regional lymph node cells after a single subcutaneous application of Phytohaemagglutinin Difco (PHA). A distinct reaction of the lymph node cells was established on the 3rd, 6th and 9th days consisting of increased number of lymphoblasts and large basophilic cells (LBC). Ultrastructural descriptive and morphometric methods were used. Authors revealed nuclear bodies to be present mostly in activated lymph node cells (lymphoblasts and LBC). Predominance of NB having RNP particles (complex type NB) was found. Simple NB (without RNP particles) had been seen rarely in small (resting lymphocytes. It was established NB to be larger, but leis im member. It is discussed on the participation of NB (Complex type) in the nuclear part of the protein synthesis.

Animals↗