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Biomedical subjects

N Vasilev

Publications and source records attributed to N Vasilev.

At least 37 records · Page 2Linked to original sources
PubMed1994

[The static and dynamic profiles of urethral pressure in women with stress incontinence and in healthy controls].

The study presents the results of urethral pressure profile measurements in 3 groups of women: continent nulliparous, continent parous and stress incontinent women. The maximum urethral closure pressure, the functional urethral length and the length of continence zone are compared. The healthy control groups (both parous and nulliparous) show much higher maximum urethral closure pressures than those mentioned in literature. No difference is evident between continent parous and continent nulliparous which suggests that vaginal delivery at term does not necessarily impair urethral sphincteric function. On the other hand women with similar age and parity with stress incontinence have a marked decrease of maximum urethral closure pressure at rest and demonstrate inability to increase it by volitional contraction of the pelvic floor. These findings support the idea of the leading role of sphincteric incompetence in stress incontinence. The functional urethral length and the length of continence zone show no significant differences among the investigated groups which implies that they are of no importance for the occurrence of stress incontinence.

Adolescent↗
PubMed1992

[The demonstration of HPV DNA in cervical intraepithelial neoplasms and in invasive carcinomas of the cervix uteri by DNA-DNA in situ hybridization].

Authors were applied a method of DNA-DNA in situ hybridization for demonstration of HPV 6, 11, 16 and 18 in cervical neoplasia and in invasion carcinoma of uterine neck. At 22 probes from CYV III and invasion carcinoma the results from hybridization with virus DNA were shown the presence of HPV-DNA at 15 patients. Some phases of method were optimized. Sensitiveness of method was controlled and compared with the results from the same probes, underlied to investigation with Southern-blot hybridization.

Adult↗
PubMed1992

[The posttherapy survival of patients with invasive cancer of the vulva].

The treatment results and five-years survival are studied in 157 patients with invasive vulvar cancer treated for the period of 1979-1988 in Gynaecological Clinic of the National Oncological Center Institute in Sofia. The general five years survival is 59.2%. The highest is the survival of the patients with first clinical stage--79.55%. The best treatment results are by patients treated with radical vulvectomy and regional lymph node dissection, without histological founded metastases in the extirpated lymph nodes--69.24% five years survival. The authors show some better results because of the better early diagnosis of the disease and the improved therapeutical methods.

Bulgaria↗
PubMed1991

Detection of human papillomavirus DNA in gynaecological swabs by filter in situ hybridization.

Gynaecological smears from the endo- and ectocervix of women with and without cytological and colposcopic abnormalities of the epithelium were investigated for human papillomavirus (HPV) types 6, 11, 16, and 18 by filter in situ hybridization (FISH). The data were compared with cytological, colposcopic, and histological findings. Of the 266 gynaecological smears, HPV DNA was detected in 84 (32%); of 101 cytologically and colposcopically HPV negative cases, HPV DNA was found in 10%. Of 56 women, cytologically and colposcopically positive for HPV infection, HPV DNA was detected in 68%. The sensitivity of the method was controlled by comparing the results of FISH with those of Southern-blot analysis of five cervical tumour biopsies. The data presented demonstrate the necessity of FISH for identification of the HPV type that might be of prognostic value in cervical pathology. Cytological and colposcopic positivity is a reliable sign in about 70% of the cases where HPV infection was proved by FISH.

Adolescent↗
PubMed1991

[2 cases of malignant insulinoma of the pancreas].

Two cases are reported of malignant insuloma: in one of the patients the tumor was hormonally active in the other inactive. Treatment was operative. The great difficulties in establishing the diagnosis preoperatively and the complications accompanying this grave disease are pointed out. The clinical and laboratory examinations which may help to reach at the correct diagnosis are discussed.

Adult↗
PubMed1991

[4 cases of botryoid sarcoma].

The authors describe the rare botryoid sarcoma--histomorphology, clinic, diagnosis, treatment and prognosis with a contribution of 4 own cases at the age up to 18 years. They indicate the difficulties in the establishment of the diagnosis-early clinical and histological-in three of the cases the histological examination did not establish immediately the exact diagnosis--the material was considered as "granulation tissue" or "fibroma mole". The results of the treatment are summarized as well as the choice of therapeutic methods and drugs. The applied therapeutic scheme consists of radical hysterectomy with systemic pelvic lymph dissection and postoperative chemotherapy. The described four cases are alive at the present moment and without data for tumourous relapse--respectively 11 years and 2 months, 3 years and 4 months, 2 years and 8 months after establishment of the diagnosis.

Adolescent↗
PubMed1990

[The diagnosis of human papillomaviruses in cervical smears by deoxyribonucleic acid hybridization].

The method of filter in situ hybridization is applied for diagnostics of human papilloma viruses of the types 11, 16 and 18 in cervical smears [correction of frictions]. The results of the hybridization of 30 cell materials with clonal virus DNA probes proved the existence of human papilloma viruses in 15 patients. The precision of the filter in situ hybridization is demonstrated by comparing the results of the cytological study to the existence of HPV DNA in the same materials proved by in situ DNA hybridization.

Autoradiography↗
PubMed1990

[The demonstration of human papillomavirus DNA in genital lesions with and without colposcopic atypism].

34 cellular suspensions from the vaginal part of women were examined for presence of HPV DNA of the types: 6, 11, 16 and 18--from a lesion and a healthy area--by filter in situ hybridization. The women were examined by colposcopy because of cervical lesions established macroscopically as well as for other various complaints. Cells were also investigated from women after undergone ablation treatment: diathermy coagulation, conization and hysterectomy on account of CIN. The data were compared with cytological, colposcopic and histological findings. The established presence of HPV DNA of high risk type 16 and 18 in some of the patients after operative treatment required continuous control of these women as well as examination of lower genital tract because of the discovered multicentricity of HPV infection.

Adolescent↗
PubMed1990

[A method for preventing the urologic complications connected with the surgical treatment of cancer of the cervix uteri].

A review on the operative methods for prophylaxis of urological complications (fistulas and strictures) due to radical hysterectomy with systemic dissection of lymph nodes is described. The authors recommend the method of T. H. Green as the most effective method. A new method for protection of the ureter with flaps, formed as a "leg" from omentum majus, is proposed. The modification has been used in 20 patients without postoperative complications. The method is recommended in cases, when postoperative stenosis or strictures of the ureters are expected as well as when postoperative irradiation is forthcoming.

Female↗
PubMed1990

[Retroperitoneal and mesenteric cysts].

Experience is recorded with the diagnosis and successful surgical treatment of 5 patients with retroperitoneal and mesenterial cysts. According to available data in the literature, one patients with retroperitoneal or mesenteric cyst falls among an average of 34,000-105,000 in-lying patients. Basic symptom on physical examination was a palpable tumor mass in the abdomen. In recent years correct preoperative diagnosis of these diseases has been established in 85-95 per cent of the cases with the help of echography and computer tomography. The surgical approach was determined from the possibility for total or partial removal of the cyst, which was sometimes accompanied by partial or total removal of abdominal organs involved in the pathologic process.

Adult↗
PubMed1990

[The importance of paraclinical indices, therapeutic and other factors for the late treatment results and prognosis in stage-Ib cervical cancer].

The study was carried out on 106 women with carcinoma of the uterine cervix at the first clinical stage, treated with the operation according to Wertheim (as single treatment and combined with gamma teletherapy of the whole pelvis--preoperative and postoperative). Survival and prognostic value of the examined factors were evaluated by Kaplan-Meier. The five-year survival of the whole population was 85.80%. The prognostic significance of tumourous volume was established: 95.78% of women with initial tumourous lesion survived five years, but 75.30% of women with advanced lesion survived. Pretherapeutic values of erythrocyte sedimentation rate had also prognostic significance--accelerates sedimentation rate was connected with lower survival. However, it was established that accelerated sedimentation rate was connected with larger tumourous volume, therefore its prognostic significance was indirect. Prognostic value with borderline statistical significance showed pretherapeutic value of hemoglobin and the season of operation. Low hemoglobin and spring-summer season of the operation indicated a tendency to a lower survival. Leucocytosis, blood grouping of the patients, time duration of the operation, etc. had no significant effect on the five-year survival.

Combined Modality Therapy↗