Biomedical subjects

N V Reshetova

Publications and source records attributed to N V Reshetova.

9 recordsLinked to original sources

PubMed1996

[Drug intolerance].

The authors present experimental data on luminol-dependent neutrophil chemiluminescence of blood from patients with drug intolerance. A decrease in intensity of neutrophil and whole blood chemiluminescence was registered in the presence of intolerated drugs. In acute phase of generalized intolerance reaction the chemiluminescence test showed readiness of the blood cells to react inadequately to the contact with different drugs leading to variations in generation of active oxygen forms. Improvement in patients' condition was followed by narrowing spectrum of drugs causing a decrease in the intensity of the chemiluminescence. Later, the chemiluminescence ratio remained low in testing only those drugs causing intolerance reaction.

Blood Donors↗

PubMed1990

[The effect of the plasma of patients with asthma of physical effort on the energy state of the lymphocytes].

The effect of the plasma obtained before and after graded submaximal exercise was examined in 10 bronchial asthma patients with the syndrome of asthma of physical effort (APE) by means of fluorescent exploration using the cation probe 4-(p-demethylaminostyryl)-1-methylpyridinum and rat thymocytes as a test system. Four normal donors and five bronchial asthma patients without the APE syndrome were used as control. The plasma of patients with the APE syndrome, obtained after physical exercise, brought about a decrease of the number of fluorescent cells. In APE patients, the coefficient of the drop of thymocyte fluorescence amounted to 0.65 +/- 0.04, that in the control group to 1.1 +/- 0.08 (p less than 0.01). It is assumed that after physical exercise in the plasma of APE patients, there may occur factor depolarizing the membrane of thymocytes, which is likely to play a substantial role in the pathogenesis of the afterload bronchospasm.

Adult↗

PubMed1990