[Role of certain mechanisms in the pathogenesis of emphysema and a number of other lung diseases].
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Biomedical subjects
Publications and source records attributed to N V Putov.
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Possible penetration of a considerable volume of air into the lesser circulation when opening the right auricle of the working heart was shown in experiments in 21 dogs. It resulted in blockade of the blood flow along the lesser circulation with a pronounced hemodynamic disturbance, pulmonary edema and penetration of air into the greater circulation vessels and possible embolisation of the latter. The experimental data have confirmed the role of air embolism of lungs in genesis of some cerebral, cardiac and pulmonary complications after operations on the open heart with the artificial blood circulation.
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The terms of incompetence of sutures of the sutured wound of the caval organs (anastomosis) were subjected to a careful retrospective analysis. In all the patients the diagnosis of failure of the sutures was confirmed in relaparotomy or in autopsy. It was established that the first signs of incompetence of sutures of intestinal anastomoses or a wound of the caval organs made their appearance within the first two days almost in two thirds of cases (118 patients) while within 3 postoperative days they developed in almost 90% of cases. The data obtained may be used for early diagnosis of incompetence of sutures of anastomoses of caval organs of the abdominal cavity.
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Under investigation were 112 patients subjected to pneumonectomy in terms from 2 to 31 years ago. Substantial disturbances of the ventilatory function, bronchial passability and pulmonary blood flow were revealed in patients with one lung. Two thirds of the patients have developed persistent pulmonary hypertension following catheterization of the right compartments of the heart, 22% of the examined patients had the latent form (revealed by physical load). The authors emphasize doubtful value of the ECG for diagnosis of pulmonary hypertension due to a pronounced change in the position of the heart after pulmonectomy.
Special microfilters made on the basis of meshy and not woven materials were used for the prevention of microembolic complications in hemotranfusions and perfusions. The results of testing and clinical use of the filters in patients during and after extracorporal perfusions following operations on the open heart are described. The advantages of not woven materials over meshy material for the filtration are shown. The postoperative course in 184 patients after the application of blood microfilters is analyzed. The positive effect is shown.
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