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Biomedical subjects

N Ushio

Publications and source records attributed to N Ushio.

At least 19 recordsLinked to original sources
PubMed1993

Cloning of human, mouse and fission yeast recombination genes homologous to RAD51 and recA.

Rad51, of Saccharomyces cerevisiae, is a homologue of recA of Escherichia coli and plays crucial roles in both mitotic and meiotic recombination and in repair of double-strand breaks of DNA. We have cloned genes from human, mouse and fission yeast that are homologous to rad51. The 339 amino acid proteins predicted for the two mammalian genes are almost identical and are highly homologous (83%) with the yeast proteins. The mouse gene is transcribed at a high level in thymus, spleen, testis and ovary and at a lower level in brain and other tissues. The rad51 homologues fail to complement the DNA repair defect of rad51 mutants of S. cerevisiae. The mouse gene is located in the F1 region of chromosome 2 and the human gene maps to chromosome 15.

Amino Acid Sequence↗
PubMed1979

Orthostatic postural activity disorders recorded by statokinesimeter in post-concussional syndromes: oculomoter aspect.

The purpose of this paper is to emphasize the influence of the mesencephalic oculomotor system regulation on orthostatic postural regulation. The body at rest is never immobile but it swings continuosly. The amplitudes and the frequencies of body sway give an indication of the function of the different sensorimotor loops which are involved in body balance. An apparatus, the statokinesimeter, allows us to record these motions by means of displacement of the body's centre of gravity with respect to the centre of the basis. In the case of head or cervical injuries, the brain stem is often implicated giving a partial nuclear unilateral lesion of the III nucleus; double vision of a few degrees with picture separation of never more than 4 degrees occurs. A compensory deviation of the head follows. A conflict between afferents from the III, IV, VI, VII, XI and supraspinal nuclei occurs. The amplitude and the frequency of the body sway change. A form of treatment is proposed for the 'pseudo-vertigo' of post-concussional syndrome.

Brain Concussion↗