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Biomedical subjects

N Uhl

Publications and source records attributed to N Uhl.

At least 19 recordsLinked to original sources
PubMed1981

[Significance of terminal deoxynucleotidyl transferase in patients with acute leukemia and malignant lymphoma: results obtained by immunofluorescence assay (author's transl)].

Deoxynucleotidyl transferase (TdT) is of diagnostic and therapeutic importance in acute leukaemia and malignant lymphoma. Previous methods for determining TdT activity by biochemical assay are complex and require the use of radioactive substances. There now is available a specific antibody for immunofluorescent demonstration of TdT. The two methods were compared on samples from 43 patients with leukemia or malignant lymphoma. There was very good agreement. High TdT activity was found in 12 of 14 patients with acute lymphatic leukemia and in one of two with acute undifferentiated leukaemia. TdT activity was absent with acute and chronic myeloid leukaemia, chronic lymphatic leukaemia and non-Hodgkin's lymphoma of low malignancy. Immunofluorescence assay, although its results are of similar significance to that obtained with the biochemical tests, is simpler to do. Furthermore, it can be done on normal bone-marrow smear or lymph-node preparations and can be correlated with the morphological findings.

DNA Nucleotidylexotransferase↗
PubMed1977

Acquired pyruvate kinase deficiency with hemolysis in preleukemia.

Acquired erythrocyte pyruvate kinase deficiency may appear as a symptom secondary to various hematologic disorders, e.g. acute leukemia, sideroblastic anemia, polycythemia vera. The case of a 68-year-old patient with PK deficiency (1.75 U/g Hb) and severe hemolytic anemia is presented, who 1 year later showed acute myeloid leukemia. It is considered that a dialysable inhibiting factor may play a pathogenetic role in this enzyme change since enzyme activity was raised by dialysis. A survey of the literature is presented.

Anemia, Hemolytic↗
PubMed1976

[Renal anemia].

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Acute Kidney Injury↗
PubMed1975

[Proceedings: Hematopoiesis in chronic pyelonephritis. Quantitative-morphological study].

Bone marrow biopsies from the iliac crest in 56 patients with chronic pyelonephritis were evaluated quantitively and correlated with renal function and peripheral blood values (n = 100). In proportion to increasing serum creatinine, mild marrow hypoplasia develops which mainly, and to a statistically significant extent, affects the percentage and amount of erythropoietic cells and megakaryocytes. The simultaneous reduction of erythrocytes and reticulocytes in peripheral blood is more pronounced and only slightly correlated to the marrow cells. There is no correlation between the number of peripheral granulocytes or the decrease in lymphocytes concomitant with uremia, and their respective precursors in the marrow.

Bone Marrow Examination↗