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Biomedical subjects

N Ueda

Publications and source records attributed to N Ueda.

At least 415 records · Page 23Linked to original sources
PubMed1985

Prostaglandins enhance trigeminal substance P-ergic responses in the rabbit iris sphincter muscles.

Contractile responses due to substance P released from the trigeminal nerve were observed after electrical transmural stimulation or exogenous application of bradykinin in the isolated rabbit iris sphincter muscle. Prostaglandins, particulary prostaglandin E1, enhanced and indomethacin inhibited these substance P-ergic responses. Since the responses to exogenously applied substance P were neither affected by prostaglandins nor indomethacin, it was suggested that prostaglandins acted presynaptically to enhance the release of substance P from the trigeminal nerve terminals.

Animals↗
PubMed1985

Chromosome aberrations in epithelial cells of the digestive tract of rats induced by 1-methyl-3-nitro-1-nitrosoguanidine.

The effect of a gastrointestinal carcinogen, 1-methyl-3-nitro-1-nitrosoguanidine (MNNG), on chromosomes of rat digestive tract epithelial cells was studied. A blind loop of colorectal segment was surgically produced and the epithelial cells of this loop were treated twice with 0.5% and 0.1% MNNG solutions, respectively (5 ml each). After the first treatment, the mucosa revealed severe damage, and repair and mitoses upon regeneration were maximal on days 4-6. Chromosomal aberrations were studied 3-48 hr after the second treatment. Cells with chromosomal aberrations increased progressively from 6 hr on, reaching their maximum level at 15 hr, and gradually returned to the original level at 48 hr. Chromosomal aberrations consisted of gaps, breaks, and exchanges. The above results indicate that gastrointestinal carcinogens induce chromosomal aberrations in target epithelial cells.

Animals↗
PubMed1985

Nonchromaffin paraganglioma in the nose and paranasal sinuses.

Nonchromaffin paraganglioma occurring in the nose and paranasal sinuses are extremely rare. The authors have experienced a case of nonchromaffin paraganglioma of nasal cavity which extended to the epipharynx. To our knowledge, this reported case is the fourth case that has appeared in the world literature. The patient, a 31-year-old female, had complained of a right nasal obstruction and mucopurulent rhinorrhea for two years. The right nasal cavity was filled with a polypoid mass showing no bleeding tendency or necrosis. Radiographs revealed a homogeneous shadow which occupied the entire nasal cavity and paranasal sinuses. Histopathological studies revealed that the tumor showed typical findings of nonchromaffin paraganglioma and neurosecretory granules in cytoplasm were observed by electron microscopic study. Subsequently, the tumor recurred at on the posterior epipharyngeal wall after a duration of one year and three months, and was removed completely. Since then, there was no recurrence of the tumor until the present time.

Adult↗
PubMed1985

Creutzfeldt-Jakob disease. An autopsy case of the panencephalopathic type and a review of the literature.

This is a case report of a purported panencephalopathic type of Creutzfeldt-Jakob (C-J) disease in a 61-year-old Japanese farmer. He died nine months after the onset of clinical symptoms. This variety of C-J disease was named and reported in 1981 by Mizutani. The characteristic feature is extensive degeneration of cerebral white matter not related to cortical damage in addition to the spongiform changes in the cortical gray matter. The case was diagnosed clinically and at post mortem marked neural loss, astrocytic macrogliosis, and degeneration of subcortical white matter were found. Senile plaques and neurofibrillary tangles were virtually absent. Degeneration of the white matter is uncommon in C-J disease, and when it occurs is usually mild, and limited in distribution.

Brain↗
PubMed1985

Dual effects of dynorphin-(1-13) on cholinergic and substance P-ergic transmissions in the rabbit iris sphincter muscle.

In the rabbit iris sphincter muscle, transmural electrical stimulation produces cholinergic and substance P-ergic responses. In the present work, the effects of dynorphin-(1-13), an endogenous ligand of the kappa opioid receptor, on these two neurogenic responses were examined pharmacologically and the data compared to findings in case of other opioid agonists. Dynorphin-(1-13) (10(-7) to 10(-6) M) enhanced the cholinergic responses and attenuated the substance P-ergic response, in a concentration-dependent manner, and these actions of dynorphin-(1-13) were more apparent in the case of low-frequency stimulation. These effects of dynorphin-(1-13) were antagonized by naloxone (10(-5) M). Dynorphin-(1-13) had no effects on the responses to exogenously applied acetylcholine, carbachol and substance P. The augmenting effect on the cholinergic transmission was unique in kappa agonists, as the cholinergic responses were also augmented by other kappa agonists such as dynorphin-(1-17) and ethylketocyclazocine, but attenuated by other opioid agonists (Met-enkephalin, beta-endorphin and morphine) and not affected by SKF-10,047 and nalorphine. On the other hand, the substance P-ergic response was attenuated by all the opioids used. These results suggest that dynorphin-(1-13) presynaptically increases the release of acetylcholine from the parasympathetic postganglionic nerves and reduces the release of substance P from the trigeminal nerve, mediated by kappa type of opioid receptors.

Acetylcholine↗
PubMed1985

[A case of Krukenberg tumor associated with elevation in blood testosterone].

One case of Krukenberg tumor associated with elevation in blood testosterone levels was reported. The patient was a 31-year-old woman. She visited the outpatient service of our hospital with the chief complaint of uterine bleeding and infertility. She was diagnosed to have an anovulatory cycle associated with elevation in blood testosterone levels. However, after an examination at our hospital, a tumor of the left ovary was pointed out and she underwent bilateral ovariectomy. Postoperatively, tarry stool was passed, for which she received an examination at the department of internal medicine. Roentgenography of the stomach and examination by a gastric camera revealed undifferentiated carcinoma of Borrmann's type III in the greater curvature of the angular area. This lesion was diagnosed to be Krukenberg's tumor and a gastrectomy was performed. On the other hand, the blood testosterone level which had shown elevation before resection of the ovaries was restored to the normal range after the operation. Various reports have been published concerning the endocrinological activity of this tumor. It remains to be elucidated whether it is due to metastasis of the carcinoma or if it originates from other ovarian parenchyma. However, it has been reported that elevation in endocrinological activity is apt to occur when the tumor originates from the digestive tract.

Adult↗
PubMed1985

[Diffuse heterotopic multiple cysts of the stomach with special reference to the histogenesis and relationship with gastric cancer].

Ten patients with diffuse multiple glands or cysts in the submucosal layer of the stomach have been extensively studied. The structure of the cyst wall showed two patterns, consisting of monolayer cuboidal or cylindrical cells and pseudoantral or parietal mucosa. All of the multiple cysts were in the submucosal layer under the gastric mucosa with intestinal metaplasia. In these mucosal layers, erosion and ulcer were frequently observed. Four patients had multiple gastric cancers, and the cancers were surrounded by the metaplastic gastric mucosa. We speculated this disorder to be a peculiar regenerative change after gastritis, especially erosion. That repeated erosion and regeneration leads to carcinoma in the stomach with diffuse, heterotopic multiple cysts.

Aged↗
PubMed1985

[Clinical studies on aztreonam following intravenous drip infusion].

Aztreonam (AZT), a new synthetic monocyclic beta-lactam antibiotic, which is resistant to beta-lactamase and has a strong and specific activity against aerobic Gram-negative bacteria including Pseudomonas aeruginosa. The patients of 13 cases with localized peritonitis due to acute appendicitis, 3 cases with panperitonitis (1 case with perforative appendicitis, 1 with acute cholecystitis and 1 with pancreatic necrosis) and 4 cases with skin and soft tissue infection (anal fistula and abdominal abscess etc.) were treated by AZT. AZT was administered in a dose of 1 g twice a day by intravenous drip infusion using 100 ml-volume bottle preparation with saline for 4 to 10 days. Clinical efficacy was rated excellent in 2 cases, good in 16 cases, fair in 1 case and poor in 1 case (efficacy rate 90.0%). Adverse effects were small skin rash in 1 case, and increased GOT and GPT in 1 case. No adverse effect was recognized in other cases. Therefore, AZT appears to be very useful drug when used for chemotherapy of infectious diseases in surgery.

Adolescent↗
PubMed1985

[Therapeutic effect of dried ion exchange resin-treated human immunoglobulin (SM-4300) against severe bacterial and/or fungal infections in surgery].

A newly developed human immunoglobulin for intravenous use, SM-4300, purified by cold ethanol precipitation and ion exchange resin, has been studied in the surgery. SM-4300 has been evaluated clinically against inpatients with severe bacterial and/or fungal infections in the combined use with the antibiotics which were resistant to antibiotic therapy. Total number of 13 patients affected with various severe infections were treated with SM-4300. Clinical effects of SM-4300 were excellent in 2 cases, good in 6, fair in 3 and poor in 2. The efficacy rate was summarized as 61.5%. No subjective and objective clinical side effects and abnormal laboratory findings were observed. In conclusion, combination therapy with SM-4300 and antibiotics was considered to be safe and effective against severe bacterial and/or fungal infections in the surgery.

Adolescent↗
PubMed1985

[Mass screening for breast cancer--the results for 15 years].

Mass screening for breast cancer has been carried out in 13 cities in Osaka Prefecture for the past 15 years. The screening method was inspection and palpation by the physician, and examination by mammography was performed for the women with abnormal findings as the second screening. Among the total of 73,488 examinees (actual number was 44,835 examinees) 3,022 (4.1%) were examined by mammography and 106 (0.14%) patients with breast cancer were detected. Seventy-two of them were found at the first screening, 15 at the subsequent screening, and 19 were interval cases. Sixty-two cases of breast cancer (63.9%) were without lymph node metastasis, and cancer in Stage I and TIS reached 37.8% in this series. These results show that our screening method is valid for detecting the earlier stages of breast cancer.

Breast Neoplasms↗
PubMed1984

Mixed connective tissue disease with fatal pulmonary hypertension and a review of literature.

The paper presents an autopsy case of mixed connective tissue disease (MCTD) with pulmonary hypertension (PH) and a review of literature. A 33-year-old woman with Raynaud's phenomenon and dyspnea of one year duration was diagnosed as having MCTD on the basis of a higher titer (1:163,840) of serum antibodies to the ribonucleoprotein (RNP). Cardiac catheterization showed complicating PH, confirmed an autopsy by the findings of concentric intimal cellular proliferation and typical plexiform lesions in the small arteries and arterioles of the lung, suggesting primary PH. Fatal PH with MCTD has been reported only 6 cases in literature including our case. All were young females, with histopathological findings consistent with plexogenic pulmonary arteriopathy in 5 cases and with recurrent pulmonary thromboembolism in the other. The aetiology of PH is still unknown, but it may be due to vasoconstriction evoked by the hyper-reactivity of the vessels.

Adult↗