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Biomedical subjects

N Tudose

Publications and source records attributed to N Tudose.

At least 19 recordsLinked to original sources
PubMed1983

Lympho-nodal fibrosclerosis in primary lymphedema. Part one: Considerations on lympho-nodal fibrosclerosis in primary lymphedema.

Segments of an inferior inguinal ganglion and of an external iliac (upper inguinal) ganglion were microscopically examined in 46 cases of bilateral primary lymphedema and 26 cases of unilateral primary lymphedema. The examination was performed bilaterally and comparatively to a set of ganglions unaffected by lymphedema, during the years 1974-1978. In all the lymph nodes originating from the patients with lymphedema important morphopathological alternations were noticed, chiefly consisting in fibrosis, fibrosclerosis, fat loading, hyalinization processes, giganto-cellular responses, etc., leading even to an aspect of cirrhosis, lympho-nodal pseudo-cirrhosis. These alterations were also found on the healthy side of the patients with unilateral primary lymphedema at the time of the microscopical examination. In the same patient clinical edema appeared in the following years. The degree of the morphopathological alterations was greater in the side of the greater edema and more peculiar in the cases of bulkier edema.

Adolescent↗
PubMed1983

Lympho-nodal fibrosclerosis in primary lymphedema. Part two: Consequences of lympho-nodal fibrosclerosis on lymph stasis in primary lymphedema.

The inguinal-iliac lympho-nodal fibrosclerotic processes appearing in female patients with primary lymphedema bring about an obvious tendency of reduction of the circulatory flux in the afferent lymphatics at some distance from the lympho-nodal area: at the foot or at the shank. The inguinal lympho-nodal morphopathological alterations (examined in 72 cases of primary lymph-edema) were followed, by distal lymph stasis at the level of the foot and of the leg, without sensibly affecting the lymph flow in the thigh. These aspects of the lymph stasis adjacent to the lympho-nodal areas are striking in the patients with secondary lymphedema.

Adolescent↗
PubMed1976

[Testing the electric resistance as an objective diagnostic test in dental pulp diseases].

The authors test by means of a measuring device of high precision the resistence of health or sick human pulpa, comparing it to them of gums, excluding in the same time the sensibility of the patient in question. The authors corroborate the obtained dates with clinical symptomatology and the histopathological photos, discussing the possibility of objective electrical test as an expedient in the diagnosis of pulpa-affections.

Adolescent↗
PubMed1975

The influence of smallpox revaccination upon the foetus.

Serological, virological, anatomo- and histopathological investigations were performed in pregnant women subjected to smallpox revaccination. Serological findings were normal; no vaccinia virus was isolated from 210 placentae collected upon therapeutical abortion. Anatomopathological investigation of 15 placentae showed various lesions, while the embryo were free from any histopathological changes. The data prove that smallpox immunization does not affect the embryo directly, but only through the placenta.

Adult↗
PubMedDate not supplied

[Recurrent thyroid neoplasm with Hürtle cells-- case report].

The thiroidian tumor with Hürtle cells represents a rare clinical form of thyroid neoplasia and has a particular biological behavior. Tumors included in this category are those in which more than half of the cell population is made up of Hürtle cells. We present the case of a 58 years old woman with a recidivant oncocitic adenoma, four years after a subtotal bilateral thyroidectomy. The pathological examination using HE, van Gieson, AgNOR stains, the positive imunoreaction for thyreoglobulin LSAB and the ultrastructural examination established the definitive diagnosis. The surgical treatment is the main therapeutic measure and must be performed under oncological curative principles: lobectomy for the benign forms and total thyroidectomy for the malignant ones. The malignant potential is higher than for other well differentiated thyroidian carcinomas.

Adenoma, Oxyphilic↗
PubMedDate not supplied

Immunohistochemical expression of prostate specific antigen (PSA) in benign and malignant tumors of the prostate.

The immunohistochemical (IHC) expression of PSA in tissue fragments has been analysed in 25 patients with benign prostatic hypertrophy (BPH) and in 50 patients with prostatic carcinoma. The fragments were obtained by transurethral resection and transvesical adenomectomy. Morphology was studied by hematoxylin-eosin and Gömöri's trichrome staining. For immunohistochemical study anti-PSA monoclonal antibodies (DAKO, EPOS) were used. In BPH cases a positive reaction in the cytoplasm of secretory luminal cells was noticed; the reaction was negative in basal and urothelial cells, in foci of squamous metaplasia and in the cells of mucous gland metaplasia. All the classic types of prostatic carcinoma, regardless of the degree of differentiation showed positive reaction with various intensity and distribution. A positive focal reaction was noticed in two ductal carcinomas of endometrioid type. The reaction was negative in transitional, epidermoid and small cell carcinoma. Though less useful in differentiating benign from malignant lesions, this method may contribute to the differential diagnosis of particular forms of prostatic tumors.

Humans↗
PubMedDate not supplied

Prognostic significance of c-erbB2 protein in endometrial cancer.

The human protooncogene c-erbB2, also known as HER-2/neu is sited on 17q21 chromosome and codifies a transmembranous glycoprotein of 185 KD, named c-erbB2 protein, with tyrosin-kinasic activity and homologue from molecular point of view with the epidermal growth factor receptor (EGFR). In order to detect the tissular expression of c-erbB2 protein, tissular samples from 10 patients with primary endometrial cancer were immmunohistochemically processed. C-erbB2 immunostaining using c-erbB2 (21N) antiserum marked the cellular membranes and, occasionally, the cytoplasma of the tumoral cells. The overexpression of c-erbB2 protein in the examed cases was correlated with the clinical status, histological type of the tumour and the differentiation degree. All the patients presented immunoreactivity of variable intensity for c-erbB2 protein. The alterations of c-erbB2 protein are considered to be an unfavourable prognostic factor implied in the tumoral progression.

Adenocarcinoma, Papillary↗
PubMedDate not supplied

Correlation between p53 expression and other prognostic factors in breast cancer.

p53 suppressor tumoral gene codifies the nuclear proteins which suppress the cellular proliferation by preventing the entrance of the cells in the division cycle. The loss or inactivation of this protein, by destruction or gene mutation, or by its link to viral oncoproteins, annuls the growths restrictions and favours the malignant transformation. The immunohistochemical determination of the p53 protein accumulation seems to be an efficient mean of selecting breast neoplasias. p53 immunostaining is positive at the level of malignant cells nuclei and negative for normal cells. For this study there were selected 30 patients with breast cancer, treated in the surgical clinics of the County Hospital from Timişoara, during 1993-1995. Immunohistochemical determination of p53 protein was performed on tissular samples formalin fixed and paraffin embedded, using mouse monoclonal antibody DAKO--p53 DO 7 p53 human antiprotein. From the 30 carcinomas studied, 9 (30%) expressed p53 protein, as found in literature. The presence of this protein was more frequent noticed in the infiltrative lobular carcinoma, comedocarcinoma and in medullary carcinoma. Five patients whose tumours presented p53 protein were postmenopausal; in 7 cases (77.7%) the tumoral differentiation degree was G1 or G2.

Adult↗