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N T Felberg

Publications and source records attributed to N T Felberg.

48 records · Page 3Linked to original sources
PubMed1976

Carcinoembryonic antigen. Its role in the evaluation of intraocular malignant tumors.

Plasma carcinoembryonic antigen (CEA) was studied in 60 patients with histologically confirmed intraocular neoplasms including 56 malignant melanomas of the uvea and four metastatic tumors to the choroid. While 45% of the patients with primary uveal melanomas, as well as 75% of the patients with metastatic disease demonstrated elevated plasma CEA levels, both patients who exhibited metastatic lesions of entodermal origin demonstrated plasma CEA values that clearly fell into a separate, highly elevated category, consistent with metastatic disease or pancreatic or colorectal carcinoma. Thus, in the patient seen with a nonpigmented choroidal mass that may represent either a choroidal hemangioma, amelanotic melanoma, or metastatic tumor, plasma CEA levels may be useful in the differential diagnosis. If the clinician suspects a metastatic tumor from an occult primary site, highly elevated CEA levels may indicate that the lesion is of entodermal origin.

Adenocarcinoma↗
PubMed1976

Fetal antigens in retinoblastoma.

Plasma carcinoembryonic antigen (CEA) and alpha fetoprotein (AFP) levels were studied in five patients with retinoblastoma. CEA and AFP were found elevated in four of five patients prior to therapy. Following enucleation and/or radiation therapy, the elevated values were significantly lowered. This preliminary study suggests that CEA and AFP levels may be of value in the diagnosis of retinoblastoma, and that serial CEA levels may be useful in evaluation of retinoblastoma patients after treatment.

Carcinoembryonic Antigen↗
PubMed1976

CEA family syndrome. Abnormal carcinoembryonic antigen (CEA) levels in asymptomatic retinoblastoma family members.

Plasma carcinoembryonic antigen (CEA) levels were studied in all available members of 17 families in which a presumed sporadic retinoblastoma had occurred. In 9 of the 17 families, close relatives of the patient had elevated CEA levels in the absence of demonstrable disease; this we have termed the "CEA family syndrome." In two families (Nos. 8 and 17) one or both parents and all of the siblings had elevated CEA levels. To our knowledge, this is the first report of abnormal CEA levels in unaffected family members of patients with nonadenocarcinoma-type malignancies. As follow-up studies of such families become available, detection of the "CEA family syndrome" may prove to be a useful means of locating individuals with inherited premalignant or malignant conditions and may provide a stimulus for additional clinical examination of asymptomatic individuals considered at risk for developing malignancies.

Adenocarcinoma↗
PubMed1975

Carcinoembryonic antigen-positive metastatic adenocarcinoma of the choroid. A case report.

Plasma carcinoembryonic antigen (CEA) levels were found to be elevated in a 62-year-old woman who came to us with a diffuse choroidal mass in the left eye. Although a metastatic tumor was suspected clinically, a thorough medical evaluation failed to detect a primary lesion and the eye was enucleated. The histologic diagnosis was metastatic adenocarcinoma. On immunohistologic assay, the choridal metastases stained positively for CEA. We believe this to be the first CEA-positive intraocular tumor to be reported.

Adenocarcinoma↗