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Biomedical subjects

N Subramanian

Publications and source records attributed to N Subramanian.

At least 91 records · Page 5Linked to original sources
PubMed1975

Growth and ascorbic acid metabolism in rats and guinea pigs fed cereal diets.

The nutritional values of the whole grain principal cereals, namely, wheat, rice, corn, and a millet bajra, were investigated by growth studies and studies on ascorbic acid metabolism in rats and guinea pigs. Growth was markedly retarded by feeding the rats unfortified whole grain cereals. Among the whole grain cereals, rice provided the lowest nutritional value, and the cooking of rice affected the nutritional value further. In weanling rats, ascorbic acid synthesis at the subcellular level was inhibited, and tissue storage of ascorbic acid was decreased in rats fed whole grain cereals. In guinea pigs fed whole grain cereals, the utilization of ascorbic acid was increased. Ascorbic acid supplementation at various levels indicated that the requirement for ascorbic acid increased five times in guinea pigs fed whole grain cereals. The increased intake of the vitamin was not needed when the whole grain cereals were enriched with 15% casein.

Animal Nutritional Physiological Phenomena↗
PubMed1975

Nutrient interrelationship of ascorbic acid and iron in rats and guinea pigs fed cereal diets.

Iron at a daily dose of 5 mg per animal was toxic to rats and guinea pigs fed unfortified whole wheat flour and whole rice flour diets. In rats, a species capable of synthesizing ascorbic acid, iron supplementation resulted only in decreased growth. In guinea pigs, iron administration resulted not only in decreased growth but also in high mortality. The apparent toxicity of iron was not observed when wheat flour was fortified with 15% casein. In guinea pigs, administration of ascorbic acid (k mg per 100 g body weight per day) along with iron not only counteracted the toxic effect of iron, but also led to a greater utilization of iron as revealed by increased hemoglobin and serum iron levels accompanied by decreased spleen iron content. Iron administration, however, resulted in decreased ascorbic acid synthesis (in rats only) and increased ascorbic acid utilization as revealed by lowered urinary, blood, and other tissue levels of the vitamin.

Animals↗
PubMed1975

Effect of ascorbic acid on histamine metabolism in scorbutic guinea-pigs.

1. In guinea-pigs fed an ascorbic-acid-free diet, as the ascorbic acid levels decreased the histamine levels in blood and urine rose steadily to maxima in about 10-12 days. The elevated histamine levels persisted in the blood and urine of scorbutic guinea-pigs and the histamine levels in lung, gastric mucosa and spleen also increased. The increased histamine content of the urine, blood and other tissues in the ascorbic-acid-depleted condition could be brought back to normal levels by administration of a single dose of ascorbic acid 5 mg/100 g body wt. guinea-pig. 3. The drop in the elevated histamine level was not due to an indirect effect of ascorbic acid on histamine forming capacity, histaminase activity or histamine release.

Amine Oxidase (Copper-Containing)↗