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Biomedical subjects

N Stewart

Publications and source records attributed to N Stewart.

At least 55 records · Page 3Linked to original sources

Genes of the protozoan parasite Babesia bovis that rearrange to produce RNA species with different sequences.

We describe a highly polymorphic gene family from the protozoan parasite Babesia bovis that encodes a complex pattern of transcripts. Gene rearrangements at this locus (designated BabR ) have generated RNA species that differ in sequence. The naturally occurring virulent field isolate Kv expresses two different sized transcripts that are identical in sequence at their 5' ends but different at the 3' ends. An avirulent derivative of this isolate, Ka, expresses not only these two transcripts but a third, of intermediate size. Analysis of cloned genomic fragments from Ka identified genes encoding all three transcripts. Two fragments contained tandemly repeated copies of the BabR genes. The gene encoding the intermediate sized transcript has undergone a rearrangement, substituting a 5' region different to that shared by the other transcripts. These results suggest that sequence diversity may play an important role in the biological function of the BabR locus.

Amino Acid Sequence↗

The value of sport in the rehabilitation of the physically disabled.

Sports for a variety of physical disabilities are discussed with regard to the classification of athletes, the sporting activities available, and the physical and psychosocial advantages to disabled groups to be gained from participation in sports. The benefits to the able-bodied community are also mentioned.

Amputation, Traumatic↗

The family meeting in critical care settings.

A routine, carefully planned meeting with families of patients in a trauma unit or critical care setting can improve coping and enhance patient care. Even though staffs in intensive care units realize that families may profoundly influence a patient's psychologic state, or may themselves be severely stressed, few units systematically address the needs of families in crisis. Common needs of families of acutely injured patients are the need to be with the patient, to learn about his condition, to feel useful, to express feeling about the situation, and to obtain emotional support. Besides addressing these needs, a family meeting can reduce family turmoil, help dispel family-staff conflict, and provide a format for educating staff about psychologic responses to life-threatening illness. The experience with eight patients in an ICU is described, and guidelines given for family meetings. Factors assuring a successful family meeting include careful attention to leadership, timing, communication, and clear priorities.

Adolescent↗